咬筋へのボツリヌス毒素注射による大顔面幅縮小に関する総説

A review on bigonial width reduction by botulinum toxin injections in masseter.

抄録

咬筋へのボツリヌス毒素注射による顔の横幅縮小の有効性を検討することは興味深い。PubMed、Cochrane Library、Google Scholar、Science Directデータベース、ResearchGateなどのオンラインデータベースを、「咬筋注射」、「ボツリヌス毒素」、「大頬骨幅縮小」、「咬筋肥大」、「下顔面輪郭形成」などのキーワードで、2022年10月までの間に検索した。合計20の論文が認められた。すべての前向き研究を対象とした。咬筋へのBT注射の患者選択、注射方法、効率、投与量、再発率、重大な副作用に関する関連データを収集した。1件を除くすべてが前向き研究であった。すべての研究で両側注射が用いられた。追跡期間は3～48ヵ月であった。このシステマティックレビューは、咬筋のボリュームを減少させることによって大頬骨幅を縮小させるボツリヌストキシン注射の有効性に焦点を当てている。望ましい結果を維持するためには、定期的に治療を繰り返すことが望ましい。施術はオフィス環境で行われ、15分以内に終了しました。処置に関連した永続的な有害事象はない。BT注射の用量と頻度を最適化するために、サンプル数の多いランダム化比較試験を含むさらなる研究が必要である。

It is of interest to study the efficacy of botulinum toxin injection in masseter reducing bigonial width of the face. Online databases such as PubMed, Cochrane Library, Google Scholar, Science Direct database and ResearchGate were searched from initiation until October 2022 using keywords such as "masseter muscle injections", "botulinum toxin," "bigonial width reduction," "masseter muscle hypertrophy," and "lower face contouring" All available retrospective as well as prospective studies, were included with specific weightage to the efficiency of Botulinum Toxin (BT) injection in masseter muscle and the technique, unfavorable events, and the extent of its effects. A total of 20 publications were acknowledged. All prospective studies were included. Relevant data on patient selection, injection methods, efficiency, dose, rate of recurrence, and significant side effects of BT injections in masseters were collected. All excluding one were prospective studies. Bilateral injections were used in all the studies. Follow up period was 3-48 months. This systematic review focuses on the effectiveness of Botulinum toxin injection in lowering the bigonial width by decreasing the volume of the masseter. Repeat treatment at regular intervals is advisable to maintain desired results. The procedure was carried out in an office environment and was completed within 15 mins. There are no permanent adverse events related to the procedure. Further studies involving randomized control trials with larger sample sizes are warranted to optimize the dose and frequency of BT injection.