Affective Switch Associated Associated With Oral, Low Dose Ketamine Treatment in a Patient With Treatment Resistant Bipolar I Depression.症例報告と文献レビュー

Affective Switch Associated With Oral, Low Dose Ketamine Treatment in a Patient With Treatment Resistant Bipolar I Depression. Case Report and Literature Review.

• Alina Wilkowska
• Łukasz Szałach
• Jakub Słupski
• Aleksandra Wielewicka
• Małgorzata Czarnota
• Maria Gałuszko-Węgielnik
• Mariusz S Wiglusz
• Wiesław J Cubała

抄録

単極性および双極性障害の治療抵抗性うつ病におけるケタミンの迅速かつ強固な抗うつ効果についてのエビデンスが増えてきているが、感情スイッチのリスクについてのエビデンスはまだ限られている。本症例は、治療抵抗性のうつ病エピソードを有する双極性I型障害患者で、2日間の躁状態が続く前に、追加治療として経口ケタミンを8回麻酔下で投与した直後に、様々な特徴を持つ躁状態への移行を経験したものである。

There is a growing evidence for the rapid and robust antidepressive effect of ketamine in unipolar and bipolar treatment resistant depression although evidence for the risk of affective switch is still limited. This case presents bipolar I disorder patient with treatment resistant depressive episode experiencing a switch to manic episode with mixed features shortly after receiving eight subanaesthetic doses of oral ketamine as an add-on treatment preceded by 2-day period of manic symptoms.

Copyright © 2020 Wilkowska, Szałach, Słupski, Wielewicka, Czarnota, Gałuszko-Węgielnik, Wiglusz and Cubała.