H1N1感染による小児の急性壊死性脳症

Acute Necrotizing Encephalopathy of Childhood with H1N1 Infection.

• Lalit Takia
• Nilamani Patra
• Karthi Nallasamy
• Lokesh Saini
• Renu Suthar
• Suresh K Angurana
• Muralidharan Jayashree

抄録

小児急性壊死性脳症（ANEC）は，高い死亡率と神経学的転帰不良を伴う季節性インフルエンザ感染症の稀で劇症的な合併症である．肺炎，ANEC，頭蓋内圧上昇（ICP）を呈し，ポリメラーゼ連鎖反応でH1N1感染が証明された4.5歳女性を対象に報告した．治療は機械換気、侵襲的なICPのモニタリングとコントロール、オセルタミビル、メチルプレドニゾロン、小児集中治療室での支持療法であった。退院時の神経学的状態は不良であったが生存していた。

Acute necrotizing encephalopathy of childhood (ANEC) is an uncommon and fulminant complication of seasonal influenza infection associated with high mortality and poor neurological outcome. We report a 4.5-year-old female who had pneumonia, ANEC, and raised intracranial pressure (ICP) with polymerase chain reaction proven H1N1 infection. Management included mechanical ventilation, invasive monitoring and control of ICP, oseltamivir, methylprednisolone, and supportive care in pediatric intensive care unit. She survived with poor neurological status at discharge.

© Thieme Medical Publishers.