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三酸化ホワイトミネラル骨材を歯髄捕捉材として用いた場合の歯髄反応の組織学的研究：二重盲検無作為化比較試験
A histological study of pulp reaction to various water/powder ratios of white mineral trioxide aggregate as pulp-capping material in human teeth: a double-blinded, randomized controlled trial.
PMID: 21718338 DOI: 10.1111/j.1365-2591.2011.01916.x.
抄録
AIM:
健康なヒトの歯髄捕捉材としてのホワイトミネラル三酸化物骨材（MTA）の様々な水/粉体比に対する組織学的な歯髄反応を比較する。
AIM: To compare the histological pulp reaction to various water/powder ratios of white mineral trioxide aggregate (MTA) as a pulp-capping material in healthy human teeth.
方法:
抜歯を予定していた無病の上顎・下顎第三大臼歯29本を機械的に露出させ、0.28、0.33、0.40の水と粉体の比率で白色MTA（ProRoot; Dentsply Maillefer、Ballaigues、スイス）で被覆し、グラスアイオノマーで修復した。30日後、歯を抜歯し、先端を切除し、10％ホルマリンに浸漬した。組織学的処理のために、歯を5μm厚さのスライスで頬側に切除し、ヘマトキシリンおよびエオシンで染色し、光顕微鏡で評価した。サンプルは、炎症の強さと種類、壊死の有無、および石灰化したブリッジの連続性、形態および厚さについて評価された。データは、Kruskal-Wallis検定およびMann-Whitney検定で分析した。
METHODOLOGY: Twenty-nine disease-free maxillary and mandibular third molar teeth, scheduled for extraction, were exposed mechanically and then capped with 0.28, 0.33 and 0.40 water/powder ratios of white MTA (ProRoot; Dentsply Maillefer, Ballaigues, Switzerland) and restored with glass ionomer. After 30 days, the teeth were extracted, resected apically and immersed in 10% formalin. For histological processing, the teeth were sectioned buccolingually in 5-μm-thick slices, stained with Haematoxylin and Eosin and evaluated by a light microscope. Samples were evaluated for intensity and type of inflammation, presence of necrosis, as well as continuity, morphology and thickness of calcified bridges. The data were analysed by Kruskal-Wallis and Mann-Whitney tests.
結果:
MTAで覆われた歯髄には，様々な水と粉体の比率で石灰化ブリッジの直径，形態，連続性，炎症の強さと種類，壊死の有無に有意な差はなかった（P > 0.05）．2本の歯は石灰化したブリッジを表示することができず，1本は歯髄の壊死を認めた．
RESULTS: There were no significant differences in the diameter, morphology and continuity of the calcified bridges, intensity and type of inflammation or presence of necrosis (P > 0.05) in the pulps covered by MTA with various water/powder ratios. Two teeth failed to display a calcified bridge, and one had a pulp necrosis.
結論:
MTAの水と粉体の比率は、健康なパルプの直接パルプキャッピングの組織学的転帰に有意な影響を与えなかった。
CONCLUSION: Water-to-powder ratios of MTA had no significant influence on the histological outcome of direct pulp capping on healthy pulps.
© 2011 International Endodontic Journal.