ヒト胎児の側頭顎関節における滑膜の発達

Development of synovial membrane in the temporomandibular joint of the human fetus.

• L O Carvalho de Moraes
• R C Tedesco
• L A Arraez-Aybar
• O Klein
• J R Mérida-Velasco
• L G Alonso

抄録

滑膜の発達は、妊娠9週から13週のヒト胎児の21個の側頭顎関節の連続切片を用いて解析した。発達12週目の2匹の胎児の切片を用いて、滑膜内膜上のマーカーCD68とHsp27の免疫組織化学的発現を行った。発達12週目には、それぞれCD68とHsp27を発現するマクロファージ様A型細胞と線維芽細胞様B型細胞が観察された。これらの結果は、滑膜の発達が関節の血管化と関節腔の形成に関係していることを示唆している。

The development of the synovial membrane was analyzed in serial sections of 21 temporomandibular joints of human fetuses at 9 to 13 weeks of gestation. Sections of two fetuses at 12 weeks of development were used to perform immunohistochemical expression of the markers CD68 and Hsp27 on the synovial lining. Macrophage-like type A and fibroblast-like type B cells, which express CD68 and Hsp27, respectively, were observed at the twelfth week of development. Our results suggest that the development of the synovial membrane is related to the vascularization of the joint and the formation of the articular cavities.