上顎前歯部挺出の生化学的および臨床的評価．

Biochemical and Clinical Assessments of Segmental Maxillary Posterior Tooth Intrusion.

抄録

.上顎第二小臼歯、第一大臼歯、第二大臼歯周囲のコンドロイチン硫酸（CS）濃度を無負荷時と負荷時とで比較し、分節性上顎後方歯牙侵入時の上顎後方歯牙侵入率を測定する。.この前向き臨床研究では、105歯（前歯部開咬を示し、上顎臼歯部後方歯牙侵入を必要とする15名の患者）を対象とした。CSレベルの検出には競合ELISAを用いた。非荷重時と荷重時の歯型をスキャンし、後方歯牙侵入距離を測定した。.無負荷時の上顎第二小臼歯、第一大臼歯、第二大臼歯（実験歯）および下顎第一大臼歯（陰性対照歯）周囲のCS濃度の中央値は、それぞれ0.006、0.055、0.056、0.012であり、負荷時の総タンパク量はそれぞれ2.592、5.738、4.727、0.163ng/gであった。実験歯周囲のCS濃度の中央値は、負荷期間中に有意に上昇した。上顎第二小臼歯および第一・第二大臼歯の侵入速度の平均は、それぞれ0.72mm/12週、0.58mm/12週、0.40mm/12週であった。.生化学的および臨床的評価から、片側50gの垂直加重による分割臼歯後方侵入治療法は十分であることが示唆された。.本研究はTCTR20170206006として登録されている。

. To compare chondroitin sulphate (CS) levels around maxillary second premolars, first molars, and second molars between the unloaded and the loaded periods and to measure the rates of intrusion of maxillary posterior teeth during segmental posterior tooth intrusion. . In this prospective clinical study, 105 teeth (from 15 patients exhibiting anterior open bite and requiring maxillary posterior tooth intrusion) were studied. Competitive ELISA was used to detect CS levels. Dental casts (during the unloaded and loaded periods) were scanned, and posterior tooth intrusion distances were measured. . During the unloaded period, the median CS levels around maxillary second premolars, first molars, second molars (experimental teeth), and mandibular first molars (negative control) were 0.006, 0.055, 0.056, and 0.012 and during the loaded period were 2.592, 5.738, 4.727, and 0.163 ng/g of total protein, respectively. The median CS levels around experimental teeth were significantly elevated during the loaded period. The mean rates of maxillary second premolar and first and second molar intrusion were 0.72, 0.58, and 0.40 mm/12 weeks, respectively. . Biochemical and clinical assessments suggested that the segmental posterior tooth intrusion treatment modality with 50 g of vertical force per side was sufficient. . The study is registered as TCTR20170206006.