グルコース-6-リン酸デヒドロゲナーゼ欠損症の3歳児における空豆摂取後のファビズム

[Favism after ingestion of fava beans in a three-year-old child with glucose-6-phosphate dehydrogenase deficiency].

• Margrethe Bordado Sköld
• Rikke Pilsgaard Svendsen
• Ellen Bøtker Pedersen

抄録

シリアの3歳の男児が空豆摂取後に急性溶血性貧血の症状を訴えて入院した。輸血で安定し、遺伝子検査でグルコース-6-リン酸デヒドロゲナーゼ（G6PD）欠乏症が判明した。酸化ストレス、例えば空豆の摂取は、影響を受けた個人に急性溶血性貧血を誘発する可能性があります。世界では約 4 億人が G6PD 欠乏症に苦しんでいます。有病率はアフリカ、地中海、中東諸国で高い。移民の増加に伴い、デンマークの医療現場でもこの状態が頻繁に発生することが予想されます。

A three-year-old Syrian boy was hospitalized with symptoms of acute haemolytic anaemia after ingestion of fava beans. He was stabilized by blood transfusion, and genetic examination revealed glucose-6-phosphate dehydrogenase (G6PD) deficiency. Oxidative stress, e.g. ingestion of fava beans, can induce acute haemolytic anaemia in affected individuals. Approximately 400 million people worldwide suffer from G6PD deficiency. The prevalence is high in African, Mediterranean and Middle East countries. Due to increased immigration, we might expect the condition to occur more often in Danish healthcare.