線維芽細胞増殖因子受容体4のがんにおける役割

Role of fibroblast growth factor receptor 4 in cancer.

• Shuya Tang
• Yilong Hao
• Yao Yuan
• Rui Liu
• Qianming Chen

抄録

線維芽細胞増殖因子受容体（FGFR）は、胚発生と成人の両方で重要な役割を果たしている。リガンドと結合すると、FGFRシグナルは活性化され、様々な生物学的プロセスに関与する様々な下流シグナルカスケードを誘発します。FGFRシグナル伝達の異常な制御は、多くの癌で検出されています。FGFR4は他のFGFRよりも後に発見されたが、癌におけるFGFR4の関与に関する情報は近年著しく増加している。本総説では、FGFR4の構造、シグナル伝達、生理機能、異常制御、がんへの影響などの最近の知見と、抗がん剤としての応用の可能性についてまとめた。

Fibroblast growth factor receptors (FGFR) play a significant role in both embryonic development and in adults. Upon binding with ligands, FGFR signaling is activated and triggers various downstream signal cascades that are implicated in diverse biological processes. Aberrant regulations of FGFR signaling are detected in numerous cancers. Although FGFR4 was discovered later than other FGFR, information on the involvement of FGFR4 in cancers has significantly increased in recent years. In this review, the recent findings in FGFR4 structure, signaling transduction, physiological function, aberrant regulations, and effects in cancers as well as its potential applications as an anticancer therapeutic target are summarized.

© 2018 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.