日本語AIでPubMedを検索
肥満者および正常体重者の慢性歯周炎患者における非外科的歯周治療の血漿活性酸素代謝物および歯肉粘膜液レジスチンおよび血清レジスチンレベルへの影響
Effect of nonsurgical periodontal therapy on plasma-reactive oxygen metabolite and gingival crevicular fluid resistin and serum resistin levels in obese and normal weight individuals with chronic periodontitis.
PMID: 30131622 PMCID: PMC6077962. DOI: 10.4103/jisp.jisp_108_18.
抄録
背景:
肥満者の過酸化状態と炎症状態の変化は、歯周病の発症と進行に影響を与える細菌感染症への感受性を高めている。
Background: The hyperoxidative and a modified inflammatory state in obese individuals cause higher susceptibility to bacterial infection which influences the initiation and progression of periodontal disease.
狙い目:
本研究の目的は、肥満または過体重の人と正常体重の人の歯周炎患者を対象に、歯肉指数（GI）、プラーク指数、ポケットプロービング深さ（PPD）およびクリニカルアタッチメントレベル（CAL）、血漿活性酸素代謝物（ROM）レベル、歯肉溝液（GCF）レジスチンおよび血清レジスチンレベルなどの臨床パラメータに対する非外科的歯周治療の役割を評価することであった。
Aim: Our study was aimed to evaluate the role of nonsurgical periodontal therapy on the clinical parameters such as gingival index (GI), plaque index, pocket probing depth (PPD) and clinical attachment level (CAL), plasma-reactive oxygen metabolite (ROM) levels, and gingival crevicular fluid (GCF) resistin and serum resistin levels in obese or overweight and normal weight individuals with periodontitis.
材料と方法:
慢性歯周炎の肥満・過体重者30名（I群）と正常体重者30名（II群）の2群に分類した。両群の臨床的パラメータ、血漿ROM値、血清およびGCFレジスチン値をベースライン時と歯周治療後2ヵ月後に評価し、比較した。
Material and Methods: Sixty individuals of age between 35 and 45 years of both the sexes were selected and categorized into two groups as thirty overweight or obese individuals with chronic periodontitis (Group I) and thirty normal weight individuals with chronic periodontitis (Group II). Clinical parameters, plasma ROM levels, and serum and GCF resistin levels were assessed at baseline and 2 months after periodontal therapy in both the groups and compared.
結果:
治療後2ヵ月後の臨床指標（GI、CAL、PPD）をグループ間比較したところ、I群に比べてII群の方が減少幅が大きく、有意差が認められた。治療2ヶ月後に血漿ROM、GCF、血清レジスチン値を比較したところ、I群に比べてII群の方が減少幅が大きかった。
Results: Intergroup comparison of clinical parameters (GI, CAL, PPD) 2 months after therapy showed a significant difference with more reduction in Group II compared to Group I. On comparison, mean plasma ROM, GCF, and serum resistin levels at baseline was higher in Group I compared to Group II. When plasma ROM, GCF, and serum resistin levels were compared 2 months after therapy, the reduction was more in Group II compared to Group I.
結論:
肥満または過体重の慢性歯周炎患者には，歯周病治療とともに，歯周健康の改善のためには減量プログラムへの患者の動機付けが必須であると結論づけられた．
Conclusion: It is concluded that along with periodontal therapy, motivation of patients for weight reduction program is mandatory for obese or overweight individuals with periodontitis in order to improve periodontal health.