硫黄-マスタード暴露後の長期重症眼障害者における免疫グロブリンの血清レベルの変化

Alteration in serum levels of immunoglobulins in seriously eye-injured long-term following sulfur-mustard exposure.

• Tooba Ghazanfari
• Ali Mostafaie
• Farideh Talebi
• Mohammad Reza Vaez Mahdavi
• Mohammad Ebrahim Yarmohammadi
• Nayere Askari
• Sakine Moaiedmohseni
• Ali Mohammad Mohseni Majd
• Ensie Sadat Mirsharif
• Zeinab Ghazanfari
• Zuhair Mohammad Hassan
• Jalaledin Shams
• Davoud Jamali
• Soghrat Faghihzadeh

抄録

序論:

硫黄マスタード（SM）は、免疫系の調節障害など、人体の局所的および全身的な変化を引き起こす強力な毒性物質である。このガスは肺、皮膚、目、消化管などの様々な器官に影響を与えます。

INTRODUCTION: Sulfur mustard (SM) is a potent toxic agent that cause local and systemic changes in the human body such as dysregulation of the immunological system. This gas affects different organs such as lungs, skin, eyes and the gastrointestinal tract.

方法:

SMに起因する眼の損傷を受けた退役軍人128人を調べ、性別と年齢をマッチさせた31人の健常対照者と比較した。IgM、IgE、IgA、IgG、IgGおよびIgGサブクラスの血清レベルをELISA法で測定した。

METHODS: 128 veterans with SM-induced eye injuries were examined and compared to 31 gender- and age-matched healthy controls. Serum levels of IgM, IgE, IgA, IgG, and IgG subclasses were measured using ELISA method.

結果:

眼球の異常と正常の２群間では、眼底結膜-四肢虚血、眼底結膜-過血症の異常を有する群を除いて、IgM値に有意差はなかった。また、IgA、IgE、IgG値についても、眼球異常のある群とない群の間では、試験群間で有意な差は認められなかった。いくつかの眼球異常のIgG1値は健常対照群と比較して有意に低値であった。間質異常のあるSM曝露群のIgG2値は、間質異常のないSM曝露群に比べて高かった。いくつかの眼球異常を有するSM曝露群のIgG2値は、対照群に比べて有意に上昇した。IgG3レベルは、眼底異常を除いて、すべての患者でコントロールと比較して有意な変化は認められなかった。また、IgG4レベルは、正常眼状態と異常眼状態の2群間で有意な差は認められなかった。それにもかかわらず、いくつかの眼球異常を呈した被験者のIgG4値は対照群と比較して有意に上昇した。

RESULTS: There was no significant difference in IgM level between two groups with abnormal and normal ocular conditions except for those having bulbar conjunctiva-limbal ischemia and bulbar conjunctiva-hyperemia abnormalities. There were not significant difference in IgA, IgE, and IgG levels between two groups with and without ocular problem also between study groups. IgG1 level in some ocular abnormalities were significantly lower than the healthy control groups. IgG2 level in SM-exposed participants with stromal abnormality was higher in the SM-exposed groups without this problem. IgG2 levels in the exposed group with some ocular problems were significantly increased compared with control. IgG3 level in all patients did not reveal any significant changes compared with the controls except the fundus abnormality. IgG4 level was not significantly different between two groups with normal and abnormal ocular conditions. Nonetheless, IgG4 level in the exposed participants with some ocular abnormalities significantly increased compared with the controls.

結論:

その結果、SM曝露は健常対照者と比較して免疫グロブリンレベルを変化させ、IgG2とIgG1レベルの変化はいくつかの眼障害と関連していることが示された。

CONCLUSION: The results showed SM exposure could alter immunoglobulins level compared with healthy controls and the changes of IgG2 and IgG1 levels were associated with some ocular problems.

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