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中国人集団における血清尿酸と眼底動脈硬化症の発症との性差別関連。レトロスペクティブな横断的研究
Gender-Specific Association between Serum Uric Acid and Incident Fundus Arteriosclerosis in Chinese Population: A Retrospective Cross-Sectional Study.
PMID: 32451435 PMCID: PMC7248060. DOI: 10.1038/s41598-020-65575-z.
抄録
血清尿酸（SUA）値の上昇は心血管疾患の危険因子と考えられていたが，動脈硬化症の増加と関連していることが明らかになった．本研究の目的は、健康な集団における SUA と眼底動脈硬化との性差を探ることであった。本研究では，レトロスペクティブ横断的研究として，糖尿病と高血圧のない2374人を対象とした．SUA値をQ1～Q4として、四分位に応じて4群に切り分けた。異なるSUA値のオッズ比と95％信頼区間を二項ロジスティック回帰モデルで推定した。SUAと眼底動脈硬化との用量反応関係を推定するために、制限的立方スプライン法を用いた。SUAと眼底動脈硬化症の発症との間の性別特異的関連を調べるために、サブグループ分析を行った。男性では、交絡因子を調整した後、SUA値が最も高い場合、眼底動脈硬化症の発症リスクと有意に関連していた。Q4の95％CI付きORはQ1を参考に1.44(1.18、1.76)であった。特に女性では、SUAレベルは眼底動脈硬化症の発症とは関連していなかった。結論として、SUA値の上昇は男性では眼底動脈硬化症の発症と関連していたが、女性では関連していなかった。
Elevated levels of serum uric acid (SUA) were considered to be risk factors for cardiovascular disease, it has been found to be associated with increased arteriosclerosis. The aim of this study was to explore the gender specific relationship between SUA and fundus arteriosclerosis in a healthy population. In a retrospective cross-sectional study, 23474 individuals without diabetes and hypertension were included in the present study. SUA levels were cut to four groups as Q1 to Q4, according to the quartiles. The odds ratio and 95% confidence interval of different SUA levels were estimated by a binomial logistic regression model. A restrictive cubic spline method was used to estimate the dose-response relationship between SUA and fundus arteriosclerosis. Subgroup analysis was performed to find the gender-specific association between SUA and incident fundus arteriosclerosis. In males, after adjusting for confounding factors, the highest SUA level was significantly associated with the risk of incident fundus arteriosclerosis. The OR with 95%CI for Q4 was 1.44(1.18, 1.76), Q1 as a reference. Specially, for females, SUA level was not associated with the incidence of fundus arteriosclerosis. In conclusion, elevated levels of SUA were associated with the incidence of fundus arteriosclerosis in males, but not in females.