口腔扁平上皮癌の女性患者と男性患者の違い：台湾における単施設レトロスペクティブ研究。

Difference between Female and Male Patients with Oral Squamous Cell Carcinoma: A Single-Center Retrospective Study in Taiwan.

• Nan-Chin Lin
• Jui-Ting Hsu
• Kuo-Yang Tsai

抄録

頭頸部癌では男性の優勢がはっきりしている。本研究では、口腔扁平上皮がん（OSCC）患者の男性と女性の臨床的・病理学的特徴を調査し、同時に生存期間の解析を行うことを目的とした。2008年1月から2018年12月までの間に患者（＝2573人）を同定し、その後、扁平上皮がん診断時年齢、生活習慣因子（喫煙習慣、ベテルナッツ咀嚼、飲酒）、病理学的米国合同委員会（AJCC）解剖学的部位、AJCC TNM病期、病理学的再発因子、初診から再発までの間隔などの特徴を分析した。女性（＝122人）と男性（＝2451人）の症例を比較した。診断時の年齢、腫瘍の解剖学的部位、喫煙習慣、ベテルナッツの咀嚼およびアルコール摂取に有意な性差が認められた（＜0.001）。その他の臨床的・病理学的特徴および生存条件には有意な性差は認められなかった。結論として、女性のOSCC患者は男性よりも高齢であり、ほとんどが口腔舌腫瘍であった。一旦OSCCを発症した患者は、台湾の集団では生存率に男女差はなかった。

There is a distinct male predominance in head and neck cancers. The present study aimed to investigate the clinical and pathological features of male and female patients with oral squamous cell carcinoma (OSCC), and to simultaneously conduct a survival analysis. Patients ( = 2573) were identified between January 2008 and December 2018, and subsequently analyzed for characteristics such as age at squamous cell carcinoma diagnosis, lifestyle factors (smoking habit, betel nut chewing and alcohol consumption), pathological American Joint Committee on Cancer (AJCC) anatomic site, AJCC TNM stage, pathological recurrence factor and interval from first diagnosis to recurrence. A case-matched comparison between female ( = 122) and male ( = 2451) patients was conducted. Significant gender differences were noted in age at diagnosis, anatomic site of the tumor, smoking habit, betel nut chewing and alcohol consumption ( < 0.001). There were no significant gender differences in the other clinical and pathological characteristics and survival conditions. In conclusion, female patients with OSCC were older than male patients with OSCC, and mostly had tumors of the oral tongue. Once patients develop OSCC, there was no difference in survival between men and women in a Taiwanese population.