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口腔扁平上皮癌におけるCD15陽性組織好酸球の定量的評価：肥満細胞と腫瘍血管新生への影響
Quantitative assessment of CD15 positive tissue eosinophils in Oral Squamous Cell Carcinoma: effects on mast cells and tumor angiogenesis.
PMID: 32610722 DOI: 10.23736/S0026-4970.19.04285-7.
抄録
背景:
本研究では、口腔扁平上皮癌（OSCC）症例の病理組織学的悪性度および臨床病期と好酸球、肥満細胞および微小血管の密度との関連性を明らかにした。
BACKGROUND: The present study determines to correlate eosinophil, mast cell and microvessel densities with the histopathological grades and clinical staging of Oral Squamous Cell Carcinoma (OSCC) cases, as the potential role of inflammatory mediators within tumor stroma remains debatable.
方法:
研究サンプルは、Well to moderately differentiated OSCC（第1群）40例とweil to moderately differentiated OSCC（第2群）20例の計60例であった。好酸球、微小血管、肥満細胞の検出には、それぞれ抗CD15抗体、抗FVIII抗体を用いた免疫組織化学、トルイジンブルー特殊染色を用いた。
METHODS: The study sample comprised 60 cases consisting of 40 cases of Well to moderately differentiated OSCC (group 1) and 20 cases of poorly differentiated OSCC (group 2). Immunohistochemistry with anti-CD15 antibody and antifactor VIII antibody; and toluidine blue special stain were employed for the detection of eosinophils, microvessels, and mast cells, respectively.
結果:
高出力場当たりの好酸球数、肥満細胞数、微小血管数の平均値は、第1群で15.37±11.86と12.62±14.30、第2群で6.00±4.84と4.51±4.51、第3群で13.96±6.25と6.62±2.05であり、好酸球数、肥満細胞数、微小血管数の平均値は、第1群で15.37±11.86と12.62±14.30、第2群で13.96±6.25と6.62±2.05であった。好酸球密度は肥満細胞密度および微小血管密度と正の相関を示した。また、原発腫瘍の大きさ（T状態）と微小血管密度の相関は統計的に有意であった（P≦0.05）。
RESULTS: The mean numbers of eosinophils, mast cells, and microvessels per high power field in group 1 and group 2 were 15.37±11.86 and 12.62±14.30, 6.00±4.84 and 4.51±4.51, 13.96±6.25 and 6.62±2.05, respectively. Eosinophil density had a positive correlation with both mast cell and microvessel density. Also, the correlation of primary tumor size (T status) with microvessel density was found to be statistically significant (P≤0.05).
結論:
OSCCにおける前述のメディエーターのコヒーシブな解釈は、これらの変数は腫瘍の分化とよく相関するが、定量化は疾患の臨床的病期分類とは相関しないことを示唆した。
CONCLUSIONS: The cohesive interpretation of the aforementioned mediators in OSCC suggested that while these variables correlate well with the differentiation of tumor, the quantification did not correlate with the clinical staging of the disease.