不適切な抗利尿ホルモン症候群を合併した再配列肺腺癌の1例

A case of rearranged lung adenocarcinoma associated with syndrome of inappropriate antidiuretic hormone.

• Yoshihiro Miyashita
• Kotaro Hanawa
• Hiroaki Kobayashi
• Takashi Kumagai
• Kie Inomata
• Toshiharu Tsutsui
• Yumiko Kakizaki
• Toshio Oyama

抄録

喫煙歴のある60歳男性が意識障害のため当院に転院した。皮膚針生検の結果，電解質異常を伴う再配列肺腺癌と診断された．肺原発病変，多発性転移ともに縮小し，電解質障害はクリゾチニブによる第一選択分子標的薬化学療法の導入後に消失した．ここでは、SIADHを合併した再配列肺腺癌に対し、クリゾチニブによる治療が成功した1例を報告する。

A 60-year-old man with a history of smoking was transferred to our hospital for consciousness disorder. A diagnosis of rearranged lung adenocarcinoma associated with a paraneoplastic electrolytic disorder was made following a cutaneous needle biopsy. Both the primary lung lesion and multiple metastases shrunk and his electrolytic disorder resolved after the introduction of a first-line molecular-targeted drug chemotherapy with crizotinib. We herein report a case of -rearranged lung adenocarcinoma accompanied by SIADH successfully treated with crizotinib.

© 2020 The Authors. Published by Elsevier Ltd.