COVID-19パンデミック時の糞便微生物移植サービスの再編成

Reorganisation of faecal microbiota transplant services during the COVID-19 pandemic.

• Gianluca Ianiro
• Benjamin H Mullish
• Colleen R Kelly
• Zain Kassam
• Ed J Kuijper
• Siew C Ng
• Tariq H Iqbal
• Jessica R Allegretti
• Stefano Bibbò
• Harry Sokol
• Faming Zhang
• Monika Fischer
• Samuel Paul Costello
• Josbert J Keller
• Luca Masucci
• Joffrey van Prehn
• Gianluca Quaranta
• Mohammed Nabil Quraishi
• Jonathan Segal
• Dina Kao
• Reetta Satokari
• Maurizio Sanguinetti
• Herbert Tilg
• Antonio Gasbarrini
• Giovanni Cammarota

抄録

COVID-19パンデミックは、SARS-CoV-2感染症とそれに伴う死亡者の指数関数的な増加をもたらし、医療従事者と施設にとって大きな課題となっている。各国は、COVID-19からの感染リスクが高まる医療従事者と患者の双方の安全を保証するための措置を含め、感染拡大を抑制するためにいくつかの予防・封じ込め措置を講じています。糞便性微生物移植（FMT）は、感染症の治療において確立された役割を持っている。パンデミックの時代にあって、FMTセンターや便バンクは、手順の安全性と質を維持しつつ、FMTへの信頼性の高い患者アクセスを確保し続けるワークフローを採用することが求められている。本ポジションペーパーでは、利用可能な最善のエビデンスに基づき、世界のFMT専門家が、患者の選択、ドナーの募集と選択、便の製造、FMT手順、患者のフォローアップ、研究活動を含むCOVID-19のFMTへの影響に関連する問題についてガイダンスを提供しています。

The COVID-19 pandemic has led to an exponential increase in SARS-CoV-2 infections and associated deaths, and represents a significant challenge to healthcare professionals and facilities. Individual countries have taken several prevention and containment actions to control the spread of infection, including measures to guarantee safety of both healthcare professionals and patients who are at increased risk of infection from COVID-19. Faecal microbiota transplantation (FMT) has a well-established role in the treatment of infection. In the time of the pandemic, FMT centres and stool banks are required to adopt a workflow that continues to ensure reliable patient access to FMT while maintaining safety and quality of procedures. In this position paper, based on the best available evidence, worldwide FMT experts provide guidance on issues relating to the impact of COVID-19 on FMT, including patient selection, donor recruitment and selection, stool manufacturing, FMT procedures, patient follow-up and research activities.

© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.