UBCラピッド検査、超音波検査、細胞診による膀胱がんの非侵襲的発見

Non-invasive Detection of Bladder Cancer by UBC Rapid Test, Ultrasonography and Cytology.

• Vivian Barak
• Dror Itzkovich
• Roland Einarsson
• Ofer Gofrit
• Dov Pode

抄録

背景・目的:

非侵襲的検査による早期の膀胱がん診断が求められている。本研究では、膀胱癌の一次診断とサーベイランスにおいて、UBC Rapid、超音波（US）、尿細胞診の3つの非侵襲的検査法を別々に、または併用して、臨床的価値を検討することを目的とした。

BACKGROUND/AIM: There is a need to diagnose early bladder cancer by non-invasive tests. This study aimed to explore the clinical value of three non-invasive methods, UBC Rapid, ultrasound (US), and urine cytology, separately and in combination, for the primary diagnosis and surveillance of bladder-cancer.

患者と方法:

膀胱癌の症状を呈した106人の患者と、経尿道的膀胱腫瘍切除術（TURB）後の経過観察患者から尿サンプルを採取した。各患者は US、膀胱鏡検査、細胞診、UBC Rapid 検査を受けた。すべての方法とその組み合わせの感度と特異度を計算し、膀胱鏡検査と生検に関連させた。

PATIENTS AND METHODS: Urine samples were obtained from 106 patients who presented with symptoms of bladder cancer and patients followed-up after transurethral resection of bladder tumors (TURB). Each patient underwent US, cystoscopy, cytology and UBC Rapid test. The sensitivity and specificity of all methods and combinations were calculated and related to cystoscopy and biopsy.

結果:

UBC Rapidと細胞診で測定した空洞尿検体の感度と特異度はそれぞれ58.3％と75.9％、57.1％と98.0％であり、USでは76.2％と98.1％であった。UBC RapidとUSの組み合わせでは，感度91.3％，特異度72.2％，UBC Rapidと細胞診の組み合わせでは，感度84.6％，特異度71.2％であった。

RESULTS: Voided urine samples assayed with UBC Rapid and cytology yielded a sensitivity and specificity of 58.3% and 75.9%, and 57.1% and 98.0%, respectively and for US 76.2% and 98.1%. The combination of all three methods resulted in a sensitivity and specificity of 95.8% and 67.3%, and the combination of UBC Rapid and US, gave a sensitivity of 91.3%, and a specificity of 72.2%, The combination of UBC Rapid and cytology yielded a sensitivity and specificity of 84.6% and 71.2%.

結論:

UBCラピッド、US、細胞診を併用することで膀胱癌の検出感度が向上しました。

CONCLUSION: Combined use of UBC Rapid, US and cytology improved the sensitivity of bladder cancer detection.

Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.