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インドにおけるコロナウイルス感染症19(COVID-19)患者における胸部コンピュータ断層撮影(CT)所見のスペクトル
Spectrum of chest computed tomographic (CT) findings in coronavirus disease-19 (COVID-19) patients in India.
PMID: 32623113 PMCID: PMC7313528. DOI: 10.1016/j.ejrad.2020.109147.
抄録
目的:
インドのコロナウイルス感染症19(COVID-19)患者における胸部コンピュータ断層撮影(CT)所見のスペクトルを報告する。
PURPOSE: To report the spectrum of chest computed tomographic (CT) imaging findings in coronavirus disease-19 (COVID-19) infected Indian patients.
方法:
本研究は、胸部CT検査を受けた逆転写酵素ポリメラーゼ連鎖反応(RT-PCR)陽性の連続した147人の患者を対象としたプロスペクティブな記述的研究である。肺の異常所見の有病率、分布、範囲、種類を記録した。
METHODS: This was a prospective descriptive study comprising 147 consecutive reverse transcriptase polymerase chain reaction (RT-PCR) positive patients who underwent CT chest. Prevalence, distribution, extent and type of abnormal lung findings were recorded.
結果:
全147例中,男性104例(70.7%),女性43例(29.3%),平均年齢40.9±17.2歳(範囲24~71歳)であった.肺実質異常は51例(34.7%)に認められたが,RT-PCR陽性96例(65.3%)では胸部CTは正常であった.呼吸困難は12.2%、脱飽和は6.1%、呼吸数増加は7.4%、併存疾患は10.9%であった。CT異常所見を有する患者のうち、両側39/51例(76.5%)、多床(88.2%)に末梢および後方分布が優勢な肺病変が一般的に認められた。不透明度の種類に関しては、GGO(ground glass opacity)が51例(100%)すべてに認められた支配的な異常であった。純粋なGGOは15例(29.4%)に認められ、狂った舗装パターンを持つGGOは15例(29.4%)に認められ、圧密を伴うGGOは21例(41.2%)に認められた。肺血管拡大は36例(70.6%)に認められた。
RESULTS: Among the total study cohort of 147 patients, 104 (70.7 %) were males and 43 (29.3 %) were females with mean age of 40.9 ± 17.2 years (range 24-71 years). We observed lung parenchymal abnormalities in 51 (34.7 %) cases whereas 96 (65.3 %) RT-PCR positive cases had a normal chest CT. Only 12.2 % of the patients were dyspneic, 6.1 % had desaturation, 7.4 % had increased respiratory rate and 10.9 % had comorbidities. Among the patients with abnormal CT findings bilateral 39/51 (76.5 %), multilobar (88.2 %) lung involvement with a predominant peripheral and posterior distribution was commonly observed. With regards to the type of opacity, ground glass opacity (GGO) was the dominant abnormality found in all 51 (100 %) cases. Pure GGO was observed in 15 (29.4 %), GGO with crazy paving pattern was seen in 15 (29.4 %) and GGO mixed with consolidation was noted in 21(41.2 %). Peri-lesional or intralesional segmental or subsegmental pulmonary vessel enlargement was observed in 36 (70.6 %) cases.
結論:
この研究では、症状が軽度で併存疾患が少ない患者が優勢であり、RT-PCR陽性患者の3分の2は胸部CTは正常であったが、残りの患者では両側に分布し、末梢に優勢なGGOの典型的な所見が認められた。
CONCLUSION: In this study population predominantly with mild symptoms and few comorbidities, two-thirds of RT-PCR positive patients had a normal chest CT; whereas the remaining patients showed typical findings of predominant GGOs with a bilateral distribution and peripheral predominance.
Copyright © 2020 Elsevier B.V. All rights reserved.