重慶地域におけるABO血液型と口腔・顎顔面悪性腫瘍との関連性に関する研究

[Research on the relationship between ABO blood type and oral and maxillofacial malignancy in Chongqing area].

• Fei Wang
• Li-Hua Qiu
• Liang Pang
• Shu-Liang Wan

抄録

目的:

重慶地域におけるABO血液型と口腔顎顔面悪性腫瘍との関係を探る。

PURPOSE: To explore the relationship between ABO blood type and oral and maxillofacial malignancy in Chongqing area.

方法:

重慶医科大学口内病院で過去5年間に診断された口腔・顎顔面悪性腫瘍患者1054名を研究対象者とし、健常者の血液型を対照群として検討した。両群間の相関関係を検証するために、SPSS 22.0 ソフトウェアパッケージとカイ二乗検定を用いた。3大がん（扁平上皮がん、腺様嚢胞がん、粘表皮がん）の患者を対象に、血液型の異なる口腔・顎顔面悪性腫瘍のOR値を比較し、各血液型の口腔・顎顔面悪性腫瘍の相対リスクを判定した。

METHODS: A total of 1054 patients with oral and maxillofacial malignant tumors diagnosed in the Stomatological Hospital of Chongqing Medical University in the past five years were selected as the research subjects, and the blood types of the healthy people were examined as the control group. SPSS 22.0 software package and Chi-square test were used to verify the correlation between the groups. The OR values of oral and maxillofacial malignancy of different blood types were compared among patients of three major cancers (squamous cell carcinoma, adenoid cystic carcinoma, mucoepidermoid carcinoma), so as to judge the relative risk of oral and maxillofacial malignant tumors of each blood type.

結果:

口腔・顎顔面悪性腫瘍患者における血液型の分布は以下の通りであった。O型(4.2%)>A型(32.8%)>B型(24.6%)>AB型(8.4%)となっており、対照者との間に有意な差はなかった。血液型O型の患者は、他の血液型の患者に比べて粘表皮癌を発症しやすかった（P＜0.05、OR=2.09、95%CI=1.04～4.17）。また、粘表皮癌患者の血液型の分布は対照群と有意に異なっていた。血液型がO型の男性は、他の血液型の男性とは異なり、アデノイド嚢胞がんや粘表皮がんの発症率が高かった（P<0.05、OR=3.06/3.06、95%CI=1.31~7.12）。

RESULTS: The distribution of blood type in oral and maxillofacial malignancy patients was as follows: O(4.2%)>A(32.8%)>B(24.6%)>AB(8.4%), there was no significant difference in blood types between the patients and the controls. Patients with blood type O were easier to develop mucoepidermoid carcinoma compared with patients with other blood types (P<0.05, OR=2.09, 95%CI=1.04~4.17). In addition, the distribution of blood type of patients with mucoepidermoid carcinoma was significantly different from the control group. Males with blood type O were different from males with other blood types, which were more susceptible to adenoid cystic carcinoma and mucoepidermoid carcinoma (P<0.05, OR=3.06/3.06, 95%CI=1.31~7.12).

結論:

重慶地域における口腔顎顔面悪性腫瘍の発生とABO血液型との間には一定の関係がある。O型血液型の人は粘表皮癌を発症しやすく、O型血液型の男性はアデノイド嚢胞癌と粘表皮癌を発症しやすい。

CONCLUSIONS: There is certain relationship between the occurrence of oral and maxillofacial malignancy and ABO blood type in Chongqing area. The population of O blood type is easier to develop mucoepidermoid carcinoma while males with O blood type are more likely to develop adenoid cystic carcinoma and mucoepidermoid carcinoma.