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異なる多嚢胞性卵巣症候群の表現型を持つ妊婦の母体と新生児の転帰。横断的研究
Maternal and neonatal outcomes among pregnant women with different polycystic ovary syndrome phenotypes: A cross-sectional study.
PMID: 32637862 PMCID: PMC7306059. DOI: 10.18502/ijrm.v13i5.7154.
抄録
背景:
妊娠は様々な代謝やホルモンの変化を伴う過程であり，多嚢胞性卵巣症候群（PCOS）はこの過程に影響を及ぼす可能性がある．
Background: Pregnancy is a process associated with various metabolic and hormonal changes, and polycystic ovary syndrome (PCOS) can affect this process.
目的:
本研究は、異なる多嚢胞性卵巣症候群の表現型を持つ妊婦の母体転帰と新生児転帰を評価し、比較することを目的とした。
Objective: This study aimed to evaluate and compare the maternal and neonatal outcomes among pregnant women with different polycystic ovary syndrome phenotypes.
材料と方法:
この横断的研究では、2003年のESHRE/ASRM基準によるPCOSを有する妊婦200人を4つの表現型グループ（A～D）に分類した。母体転帰として、妊娠糖尿病、妊娠誘発性高血圧症、早発性膜破裂、早産、妊娠低年齢出産、子宮内発育制限、子宮内死亡率、子癇前症、中絶、羊水障害、分娩方法、帝王切開の原因などをグループ間で検討した。さらに、新生児体重、新生児回復、5 分間アッガースコア、新生児黄疸、NICU 入院の必要性、入院原因、乳児死亡率などの新生児転帰を調査し、群間で比較した。
Materials and Methods: In this cross-sectional study, 200 pregnant women with PCOS according to the 2003 ESHRE/ASRM criteria were categorized into four phenotype groups (A-D). The maternal outcomes include gestational diabetes mellitus, pregnancy-induced hypertension, premature rupture of membranes, preterm labor, small-for-gestational age birth, intrauterine growth restriction, intrauterine mortality, preeclampsia, abortion, amniotic fluid disorders, delivery method, and cause of cesarean section were studied between groups. Additionally, neonatal outcomes such as neonatal weight, neonatal recovery, 5-min Apgar score, neonatal icter, the need for NICU admission, the cause of hospitalization, and infant mortality rate were investigated and compared among the groups.
結果:
その結果、表現型はD型（37％）が最も多かった。妊娠糖尿病のリスクは表現型Aが他の表現型に比べて高く、妊娠誘発性高血圧症は表現型Bが最も多く、新生児合併症についてはPCOSの表現型間で有意差は認められなかった。
Results: According to the results, phenotype D (37%) was the most common phenotype among the participants. The risk of gestational diabetes was more common in phenotype A than in the other phenotypes, whereas pregnancy-induced hypertension was most common in phenotype B. No significant differences were observed in the neonatal complications among the PCOS phenotypes.
結論:
PCOSの表現型AとBでは妊娠糖尿病と妊娠誘発性高血圧のリスクが高いことを考えると、これらの表現型を持つ女性には、より正確な出生前ケアが必要である。
Conclusion: Considering the higher risk of gestational diabetes mellitus and pregnancy-induced hypertension in PCOS phenotypes A and B, women with these phenotypes need more precise prenatal care.
Copyright © 2020 Dehghani Firoozabadi et al.