道路運送労働者のがんリスク：60万人年の追跡調査を行った全国代表コホート研究

Cancer risk in road transportation workers: a national representative cohort study with 600,000 person-years of follow-up.

• Wanhyung Lee
• Mo-Yeol Kang
• Jihyun Kim
• Sung-Shil Lim
• Jin-Ha Yoon

抄録

韓国国民健康保険サービスのデータベースを用いて、交通機関の大気汚染と自動車のエンジン排気ガスにさらされた道路運送労働者（RTW）のがんリスクを分析した。RTWは、道路運送を行う運送労働者グループの個人と定義した。3年間の洗浄期間内に癌の初診歴がある者を罹患例と定義した。RTWの全がんリスクの粗罹患率、標準化罹患率（SIR）、および95％信頼区間（CI）を、公務員または労働力人口全体のがんリスクと比較した。合計で3,074例のがん症例がRTWで発見された。全人口と比較したRTWにおけるがんのSIRおよび95％CIは、肝臓および肝内胆管がん1.15および1.04-1.27、その他の消化器がん1.28および1.04-1.57、気管、気管支および肺がん1.28および1.15-1.43、膀胱がん1.26および1.03-1.52であった。対応するSIRと95％CIも、RTWでは公務員よりも高かった。RTWは、肝臓、肝内胆管、その他の消化器、気管、気管支、肺、膀胱のがんを含むがんの発症リスクが高い。私たちの結果は、RTWの様々ながんの予防戦略を確立するのに役立ちます。

We analysed cancer risk in road transportation workers (RTWs) exposed to traffic air pollution and motor vehicle engine exhaust using the Korean National Health Insurance Service database. RTWs were defined as individuals in the transportation workers group doing road transportation. First admission history of cancer within a 3-year wash-out period was defined as an incident case. The crude incidence, standardised incidence ratio (SIR), and 95% confidence interval (CI) of all cancer risk of RTWs were compared with those of government employees or the whole working population. In total, 3,074 cancer cases were found among RTWs. The respective SIRs and 95% CIs for cancers in RTWs compared with those in the whole population were as follows: liver and intrahepatic bile duct cancers, 1.15 and 1.04-1.27; other digestive organ cancers, 1.28 and 1.04-1.57; trachea, bronchus, and lung cancers, 1.28 and 1.15-1.43; and bladder cancer, 1.26 and 1.03-1.52, respectively. The corresponding SIRs and 95% CIs were also higher in RTWs than in government employees. RTWs have a high risk of developing cancer, including cancer in the liver, intrahepatic bile ducts, other digestive organs, trachea, bronchus, lung, and bladder. Our results can assist in establishing prevention strategies for various cancers in RTWs.