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インスリノーマの検出と位置情報における血管CTとマルチディテクターCTの比較
Comparison of angio-CT versus multidetector CT in the detection and location for insulinomas.
PMID: 32654756 DOI: 10.1016/j.crad.2020.05.012.
抄録
AIM:
インスリノーマの検出と位置検出における血管造影断層撮影(CT)とマルチディテクターCT(MDCT)の診断性能を比較する。
AIM: To compare the diagnostic performance of angio-computed tomography (CT) with multidetector CT (MDCT) in the detection and location for insulinomas.
材料および方法:
2015年4月から2018年4月までに、臨床的にインスリノーマが疑われる症例でMDCTと血管CTを受けた60例の連続した患者をレトロスペクティブに同定した。腫瘍、正常膵実質、腫瘍対膵コントラストの CT 減衰値を、両法の動脈相(AP)と門脈相(PVP)で、2 人の放射線技師が観察者間一致で定量的に測定した。基準となる手術所見と病理所見をもとに検出感度と局在精度を算出し、カイ二乗検定を用いて両法間で比較した。診断性能を比較するために、レシーバー操作特性(ROC)分析を行った。
MATERIALS AND METHODS: From April 2015 to April 2018, 60 consecutive patients who underwent MDCT and angio-CT for clinically suspected insulinomas were identified retrospectively. The CT attenuation values of tumours, normal pancreatic parenchyma, and tumour-to-pancreas contrast were measured quantitatively in the arterial phase (AP) and portal venous phase (PVP) of both methods by two radiologists with interobserver agreement. The detection sensitivity and localisation accuracy were calculated based on surgical and pathological findings, which are the reference standard, and compared between both methods using the chi-square test. Receiver operating characteristic (ROC) analysis was performed to compare diagnostic performance.
結果:
平均年齢53.8歳(範囲21~69歳)のインスリノーマ患者54例をレビューした。検出感度はMDCTで68.5%、位置精度は58.3%、血管CTで94.4%、90.7%であった;血管CTの検出感度および位置精度はMDCTよりも有意に高かった(p < 0.05)。腫瘍から膵臓への平均減衰量は、MDCTでは105.1±25 HU、angio-CTでは285±48.7 HUであった。MDCTとAngio-CTの間では、APにおける腫瘍と膵臓のコントラストに有意な差があった(p < 0.05)。Az値はangio-CTとMDCTのAPでは0.93と0.84、PVPでは0.62と0.54であった。インスリノーマの検出はアンジオCTのAPの方が有意に精度が高かった(p < 0.05)。
RESULTS: Fifty-four patients with insulinoma with a mean age of 53.8 years old (range 21-69 years) were reviewed. The detection sensitivity and location accuracy were 68.5%, 58.3% for MDCT and 94.4%, 90.7% for angio-CT, respectively; the detection sensitivity and location accuracy of angio-CT were significantly higher than those obtained with MDCT (p < 0.05). The mean tumour-to-pancreas attenuations were 105.1±25 HU in the AP of MDCT and 285±48.7 HU in the AP of angio-CT. There were significant differences in the tumour-to-pancreas contrast in the AP between MDCT and angio-CT (p < 0.05). The Az values were 0.93 and 0.84 for the AP of angio-CT and MDCT, 0.62 and 0.54 for the PVP. The AP of angio-CT was significantly more accurate for insulinoma detection (p < 0.05).
結論:
Angio-CTはMDCTと比較して、腫瘍の明瞭度が高く、インスリノーマの検出および位置が優れていることがわかった。
CONCLUSION: Angio-CT produces higher tumour conspicuity and is superior in the detection and location of insulinomas compared to MDCT.
Copyright © 2020 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.