非黒色腫皮膚癌におけるSOX18発現のハイリスク患者予測における意義：予備的研究

Significance of SOX18 expression in nonmelanoma skin cancers for prediction of high-risk patients: a preliminary study.

• Yomna Mazid El-Hamd Neinaa
• Amal Ahmad El-Ashmawy
• Hanan Al-Saeid Alshenawy
• Enas Elsaid Ahmed Arakeeb

抄録

背景:

SOX18は、血管新生とリンパ管新生の両方で内皮細胞の分化に関与する重要な転写因子である。そのため、腫瘍の進行と転移に関与していると考えられている。

BACKGROUND: SOX18 is an integral transcription factor that is involved in endothelial cells differentiation during both angiogenesis and lymphangiogenesis. Therefore, it has been implicated in tumor progression and metastasis.

目的:

脂漏性角化症（SK）および正常対照皮膚と比較して、非黒色腫皮膚癌（NMSC）におけるSOX18の発現を調べ、腫瘍の進化および進行におけるSOX18の役割を評価すること。

OBJECTIVE: To study SOX18 expression in nonmelanoma skin cancers (NMSCs) in comparison to seborrheic keratosis (SK) and normal control skin, and to assess its probable role in tumor evolution and progression.

患者と方法:

PATIENTS AND METHODS: This study was conducted on 60 specimens of NMSCs: 30 basal cell carcinomas (BCC) and 30 squamous cell carcinomas (SCC), 30 specimens of SK, and 30 normal skin specimens. All were examined for immunohistochemical expression of SOX18 antibody. Additionally, morphometric assessment of vessel density (blood & lymphatic) in each specimen was estimated.

結果:

研究したすべての皮膚腫瘍において、対照皮膚と比較して有意な SOX18 の過剰発現が観察された。SOX18発現のスコアが最も高かったのはSCC、次いでBCC、最も低かったのはSKであり、両者の間に有意な差が認められた。さらに、BCC、SCCともに高リスク型では、低リスク型に比べてSOX18発現の有意な上昇が認められた。また、間葉系血管密度の平均値は、SCCが最も高く、次いでBCC、SKの順であった。調査した腫瘍におけるSOX18発現と血管密度との間には正の相関が認められた。

RESULTS: Significant SOX18 overexpression was observed in all studied cutaneous tumors in comparison to control skin. The highest score of SOX18 expression was detected in SCC, then BCC, and the least expression was reported in SK with significant difference between them. Furthermore, significant upregulation of SOX18 expression was observed in high-risk types of both BCC and SCC compared to low-risk types. Stromal vessel density showed significant differences between the studied tumors with the highest mean value in SCC, followed by BCC and then SK. Positive correlation between SOX18 expression in the studied tumors and their vessel density was detected.

結論:

SOX18は、血管新生とリンパ管新生の両方を誘導することにより、NMSCの進化と進行に潜在的な役割を果たしている可能性がある。さらに、SOX18は予後不良のNMSC患者の予測にも有用であると考えられた。

CONCLUSIONS: SOX18 may have a potential role in the evolution as well as progression of NMSCs, possibly through induction of both angiogenesis and lymphangiogenesis. Furthermore, it could be beneficial for prediction of NMSC patients with poor prognosis.

© 2020 the International Society of Dermatology.