主要な妊娠合併症に関与する遺伝的多型：レビュー

Genetic Polymorphisms Implicated in Major Pregnancy Complications: a Review.

• Georgios Dryllis
• Panagiota Liakou
• Marianna Politou

抄録

妊娠短期または長期の合併症は、母体の健康、胎児の健康、またはその両方に関わる可能性がある。Medline（PubMed）、Science Direct、Web of Science、Google Scholarから2018年10月までの研究を含むシステマティックな文献レビューを実施した。対象としたのは、高血圧、妊娠糖尿病、子癇前症、妊娠喪失、子宮内膜死、胎盤不整脈、早産、子宮内発育遅延など、妊娠を高リスク状態にする可能性のある妊娠合併症の遺伝的背景に関する2018年までに発表された研究で、以下の包含基準を満たした164の論文を同定し、レビュー・分析を行った。これまでの結果は矛盾しており、これらの妊娠合併症の病原性は不明のままであった。特定の妊娠合併症と強い相関関係を持つ遺伝的多型の同定は、主要な妊娠合併症の早期発見と治療を容易にすることができる診断アルゴリズムに組み込むことができる有用なツールを提供する可能性があります。

Pregnancy short- or long-term complications may involve the mother's health, the fetus's health, or both. A systematic literature review was performed, including studies up to October 2018 from Medline (PubMed), Science Direct, Web of Science and Google Scholar. The following inclusion criteria were applied: studies published until 2018 concerning the genetic background of pregnancy complications such as high blood pressure, gestational diabetes, preeclampsia, pregnancy loss, endometrial death, placental abruption, premature labor, and intrauterine growth retardation which may render pregnancy a high risk condition.We identified 164 articles that met the inclusion criteria and reviewed and analyzed them. The results so far are contradictory and the pathogenicity of these pregnancy complications remains unclear. For most of the polymorphisms studied so far, data refer to small studies size but research is on-going.The identification of genetic polymorphisms with strong correlations with certain pregnancy complications could provide us with useful tools which could be incorporated in diagnostic algorithms that could facilitate early detection and treatment of major pregnancy complications.

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