筋腫性子宮内膜の大細胞神経内分泌癌

Large-cell Neuroendocrine Carcinoma of the Endometrium in Myomatous Uterus.

• Spasimir T Shopov
• Benyamin L Anavi
• Dobrin K Krastev

抄録

子宮内膜大細胞神経内分泌癌は、治療法の種類に関わらず生存期間が短い侵攻性腫瘍であり、十分な研究がなされていない。蓄積された臨床的・形態学的証拠から、大細胞型と小細胞型の神経内分泌カルチノーマは、組織学や局所発生（子宮体・子宮頸部）によって異なるバリエーションにすぎないのか、あるいはそれぞれの臨床徴候、形態、治療法、予後を持つ独立した形態にすぎないのか、という疑問が生じている。

Large-cell neuroendocrine carcinoma of the endometrium is an insufficiently researched aggressive tumor with a short survival regard-less of the treatment type.We present here the 38th consecutive case of literature reported cases of large cell neuroendocrine carcinoma of the endometrium (posi-tive for synaptophysin, CD56, chromogranin A, p53, and Vimentin) found in the myomatous uterus of a 76-year-old woman.We also describe in the study the morphological algorithm for differentiation of malignant blastomas with small (under 10 %) neuro-endocrinal component.Accumulated clinical and morphological evidence raises the question whether the large-cell and the small-cell neuroendocrine carcino-mas are just different variations according to their histology and topical occurrence (uterine body/cervix) or they are just independent forms with their respective clinical signs, morphology, treatment, and prognosis.

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