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冠状動脈性心疾患を有する高齢者における心拍変動と関連する発生源特異的PM。地域社会を基盤としたパネル研究
Source specific PM associated with heart rate variability in the elderly with coronary heart disease: A community-based panel study.
PMID: 32668362 DOI: 10.1016/j.chemosphere.2020.127399.
抄録
There is increasingly concern that PM constituents play a significant role in PM-related cardiovascular outcomes. However, little is known about the associations between specific constituents of PM and risk for cardiovascular health. To evaluate the exposure to specific chemicals of PM from various sources and their cardiac effects, a longitudinal investigation was conducted with four repeated measurements of elderly participants' HRV and PM species in urban Beijing. Multiple chemicals in PM (metals, ions and PAHs) were characterized for PM source apportionment and personalized exposure assessment. Five sources were finally identified with specific chemicals as the indicators: oil combustion (1.1%, V & PAHs), secondary particle (11.3%, SO & NO), vehicle emission (1.2%, Pd), construction dust (28.7%, Mg & Ca), and coal combustion (57.7%, Se & As). As observed, each IQR increase in exposure to oil combustion (V), vehicle emission (Pd), and coal combustion (Se) significantly decreased rMSSD by 13.1% (95% CI: -25.3%, -1.0%), 27.4% (95% CI: -42.9%, -7.6%) and 24.7% (95% CI: -39.2%, -6.9%), respectively, while those of PM mass with decreases of rMSSD by 11.1% (95% CI: -19.6%, -1.9%) at lag 0. Elevated exposures to specific sources/constituents of PM disrupt cardiac autonomic function in elderly and have more adverse effects than PM mass. In the stratified analysis, medication and gender modify the associations of specific chemicals from variable sources with HRV. The findings of this study provide evidence on the roles of influential constituents of ambient air PM and their sources in terms of their adverse cardiovascular health effects.
Copyright © 2020. Published by Elsevier Ltd.