2019年新型コロナウイルス（COVID-19）肺炎3例の臨床所見と胸部CT所見

Clinical features and chest CT findings of 3 cases of 2019 novel coronavirus (COVID-19) pneumonia.

• Xiaoyan Hu
• Jie Gou
• Liang Guo

抄録

2019年12月以降、2019年新型コロナウイルス（COVID-19）による新型急性呼吸器疾患が中国・武漢に出現した。現在、呼吸器検体または血液検体中のウイルス核酸陽性が診断の金字塔となっていますが、核酸検査が偽陰性の場合があります。COVID-19肺炎の診断には胸部CT検査が重要な役割を果たしている。COVID-19肺炎患者3例の臨床症状，検査項目，胸部CT検査の特徴を報告した．3例の主な臨床症状は発熱であった．白血球数，好中球数，リンパ球数は正常であり，C反応性蛋白のみがわずかに上昇していた．咽頭スワブのリアルタイム蛍光ポリメラーゼ連鎖反応は陰性であった。胸部CTでは両側肺末梢に多焦点性の地上硝子体混濁を認めた。肺末梢に多焦点性の硝子体混濁を認め、圧密、気管支像、血管拡大、ハローサインを認めた。COVID-19肺炎の初期段階では，臨床検査値は正常，核酸検査は偽陰性の可能性がある．COVID-19肺炎の診断には胸部CT検査が有用である。

Since December 2019, a new type of acute respiratory disease caused by the 2019 novel coronavirus (COVID-19) appeared to Wuhan, China. Currently, positive of virus nucleic acid in respiratory or blood samples is the gold standard for the diagnosis of the disease, but the nucleic acid test may be false negative. Chest CT examination plays an important role in diagnosis of COVID-19 pneumonia. The clinical manifestations, laboratory examination, and chest CT characteristics of 3 patients with COVID-19 pneumonia were reported. The mainly clinical manifestation of the 3 patients was fever. White blood cell, neutrophil cell, and lymphocyte cell count can be normal, only C-reactive protein slightly elevated. Real-time fluorescence polymerase chain reaction of throat swab detection can be negative. Chest CT showed multifocal ground-glass opacities in the peripheral of bilateral lungs. Ground-glass opacities with consolidation, air bronchogram, vascular enlargement, and halo sign were found. In the early stages of COVID-19 pneumonia, the laboratory parameters may be normal, the nucleic acid test may be false negative. Chest CT examination may be helpful for diagnosis of COVID-19 pneumonia.

© 2020 The Authors. Published by Elsevier Inc. on behalf of University of Washington.