慢性骨髄炎、骨関節壊死、薬剤関連顎骨壊死の骨単光子放射型コンピュータ断層撮影-CTピーク標準化アップテイク値

Bone single-photon emission computed tomography-CT peak standardized uptake value for chronic osteomyelitis, osteoradionecrosis and medication-related osteonecrosis of the jaw.

抄録

はじめに:

近年，SPECT-CTの評価にSUV（standardized uptake value）が適用されている．本研究は，慢性骨髄炎，骨関節壊死，薬剤関連顎骨壊死（MRONJ）に対する骨SPECT-CTピークSUVを検討するために行われた．

INTRODUCTION: Recently, standardized uptake value (SUV) has been applied for the evaluation of SPECT-CT. This study was performed to investigate the bone SPECT-CT peak SUV for chronic osteomyelitis, osteoradionecrosis and medication-related osteonecrosis of the jaw (MRONJ).

方法:

顎の病変を有する 65 例（慢性骨髄炎 12 例、骨関節炎 12 例、MRONJ 41 例）にテクネチウム-99m ヒドロキシメチレンジホスホネートを注入後、SPECT-CT を行った。GI-BONEソフトウェアを用いて，慢性骨髄炎と骨関節壊死およびMRONJのピークSUVを比較した．ピークSUVの統計解析はTukey's HSDテストによる一元配置反復測定分散分析で行った．P値0.05未満を統計的に有意とした。

METHODS: Sixty-five patients with jaw lesions (12 chronic osteomyelitis, 12 osteoradionecrosis and 41 MRONJ) underwent SPECT-CT after injection of technetium-99m hydroxymethylene diphosphonate. The peak SUV was compared for the chronic osteomyelitis with osteoradionecrosis and MRONJ using GI-BONE software. Statistical analyses for the peak SUV were performed by one-way repeated measures analysis of variance with Tukey's HSD test. A P-value lower than 0.05 was considered as statistically significant.

結果:

慢性骨髄炎のピークSUV（15.6±4.4）は、骨関節壊死のピークSUV（6.7±2.1、P=0.000）およびMRONJのピークSUV（10.7±6.1、P=0.019）に比べ、有意に高かった。

RESULTS: Peak SUV for chronic osteomyelitis (15.6 ± 4.4) was significantly higher than those for osteoradionecrosis (6.7 ± 2.1, P = 0.000) and MRONJ (10.7 ± 6.1, P = 0.019).

結論:

GI-BONEソフトを用いたSPECT-CTピークSUVは，慢性骨髄炎，骨関節壊変，MRONJなどの顎骨病変の評価に有用である．

CONCLUSION: The SPECT-CT peak SUV using GI-BONE software can be useful for the evaluation of jaw lesions, such as chronic osteomyelitis, osteoradionecrosis and MRONJ.