必須アミノ酸をベースとした特別に配合された栄養補給食品を毎日摂取すると、身体機能の低い高齢者の身体機能が改善される

Daily consumption of a specially formulated essential amino acid-based dietary supplement improves physical performance in older adults with low physical functioning.

• Azhar Gohar
• Jeanne Y Wei
• Scott E Schutzler
• Karen Coker
• Regina V Gibson
• Mitchell F Kirby
• Arny A Ferrando
• Robert R Wolfe

抄録

我々は、低身体機能高齢者（LPF）において、必須アミノ酸（EAAs）をベースとした特別に配合された栄養補助食品を毎日摂取すると、同量のホエイプロテインを摂取した場合と比較して身体機能が改善されるという仮説を検討した。ホエイプロテインを6週間摂取した後（n=32）、6分間の歩行距離には影響はなかったが、12週間のホエイ摂取後には歩行距離は以前の値から有意に改善した。EAA摂取（n=28）は、6週目、12週目ともに歩行距離を有意に改善した。12週目の歩行距離（419.0 +/- 25.0 m）は、前値の384.0 +/- 23.0 mよりも35.4 m増加した（p＜0.001）。また、EAA群の歩行距離の増加は、6週目と12週目の両方でホエイ群よりも有意に大きかった（p＜0.01）。対照的に、対照群（n=32）では歩行距離の減少が認められた（統計的に有意ではなかった、NS）。また，EAA 補給は，握力と脚力を改善し，体重と脂肪量を減少させた．血漿中LDL濃度はEAA群で有意に低下し、マクロファージ遊走阻害因子の濃度も低下した。いずれの群においても有害反応は認められず，サプリメントを摂取したすべての個人においてコンプライアンスは95％以上であった．

We have investigated the hypothesis that nutritional supplementation of the diet in low-physical-functioning (LPF) older individuals with a specially formulated composition based on essential amino acids (EAAs) would improve physical function as compared to supplementation with the same amount of whey protein. A third group of comparable volunteers were given nutrition education but no supplementation of the diet.After 6 weeks of whey protein supplementation (n=32) there was no effect on the distance walked in 6 minutes, but the distance walked improved significantly from the pre-value after 12 weeks of whey supplementation. EAA consumption (n=28) significantly improved walking distance at both 6 and 12 weeks. The distance walked at 12 weeks (419.0 +/- 25.0 m) was 35.4 m greater than the pre-value of 384.0 +/- 23.0 m (p< 0.001). The increase in distance walked by the EAA group was also significantly greater than in the whey group at both 6 and 12 weeks (p< 0.01). In contrast, a decrease in distance walked was observed in the control group (n=32) (not statistically significant, NS). EAA supplementation also improved grip strength and leg strength, and decreased body weight and fat mass. Plasma LDL concentration was significantly reduced in the EAA group, as well as the concentration of macrophage migration inhibitory factor. There were no adverse responses in any groups, and compliance was greater than 95% in all individuals consuming supplements.We conclude that dietary supplementation with an EAA-based composition may be a beneficial therapy in elderly individuals with low physical functional capacity.

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