初代および永久歯エナメル質の人工白斑病変に対する機能性リン酸三カルシウムペーストおよびCPP-ACPFの再石灰化能の評価

An Evaluation of Remineralization Potential of Functionalized Tricalcium Phosphate Paste and CPP-ACPF on Artificial White Spot Lesion in Primary and Permanent Enamel.

• Neha Bhadoria
• Mohit K Gunwal
• Rinky Kukreja
• Satish Maran
• Shashikiran N Devendrappa
• Shilpy Singla

抄録

目的:

エナメル質に人工的に形成されたホワイトスポットに対して、機能性リン酸三カルシウムペースト（fTCP）およびカゼインホスホペプチド-非晶質リン酸カルシウム（CPP-ACPF）ペーストの再石灰化能を、走査型電子顕微鏡およびマイクロハードネス評価により調査・評価する。

Aim: Investigation and evaluation of remineralization potential of functionalized tricalcium phosphate paste (fTCP) and casein phosphopeptide-amorphous calcium phosphate (CPP-ACPF) paste on artificially created white spot lesion on human primary and permanent enamel through scanning electron microscopy and microhardness assessment.

材料と方法:

抜歯したばかりの乳歯と永久歯60本を選び、標準的な脱灰液を用いて人工的なホワイトスポット病変を形成した。テストペーストを用いて再石灰化を行った。脱灰と再石灰化の評価は，走査型電子顕微鏡とマイクロハードネス評価によって行った．

Materials and methods: Sixty freshly extracted primary and permanent teeth were selected and artificial white spot lesion were created by using standardized demineralizing solution. Remineralization was carried out using the test pastes. The assessment of demineralization and remineralization was done through a scanning electron microscope and microhardness assessment.

結果:

3群のうち，fTCPは，CPP-ACPFおよびControl群と比較して，ANOVAおよびLSD検定により，平均微小硬さが有意に増加した（< 0.001）。また，不対検定の結果，両実験群の異なる時間間隔において，永久歯の平均微小硬さの変化が乳歯よりも有意に高いことが示された．表面形態は、走査型電子顕微鏡で評価した。

Results: Among the three groups, fTCP shows significantly higher increase in mean microhardness ( < 0.001) through ANOVA and the LSD test when compared to CPP-ACPF and control group. Also, the unpaired -test showed that mean change in microhardness in permanent teeth was significantly higher than primary teeth in different time intervals for both experimental groups. Surface morphology was assessed through a scanning electron microscope.

結論:

本研究の結果から，f-TCPはCPP-ACPに比べて比較的高い再石灰化能を示すことが明らかになった．

Conclusion: Based on the results of the current study, f-TCP showed comparatively more remineralization potential than CPP-ACP with fluoride.

この論文の引用方法:

Bhadoria N, Gunwal MK, Kukreja R, An Evaluation of Remineralization Potential of Functionalized Tricalcium Phosphate Paste and CPP-ACPF on Artificial White Spot Lesion in Primary and Permanent Enamel.Int J Clin Pediatr Dent 2020;13(6):579-584.

How to cite this article: Bhadoria N, Gunwal MK, Kukreja R, An Evaluation of Remineralization Potential of Functionalized Tricalcium Phosphate Paste and CPP-ACPF on Artificial White Spot Lesion in Primary and Permanent Enamel. Int J Clin Pediatr Dent 2020;13(6):579-584.

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