異なる菌の再活性化を伴う歯周炎患者の術後における抗抗酸化系指標の動態について

DYNAMICS OF ANTI-ANTIOXIDANT SYSTEM INDICATORS IN THE POSTOPERATIVE PERIOD IN PATIENTS WITH PERIODONTITIS ACCOMPANIED BY DIFFERENT REACTIVATY OF THE ORGANISM.

抄録

目的:

パッチテスト手術後の正常、高、低反応を伴う全身性歯周炎患者の血液中の過酸化脂質と抗酸化作用の動態を調べることを目的とする。

OBJECTIVE: The aim is to study the dynamics of lipid peroxidation and antioxidant protection in the blood of patients with generalized periodontitis accompanied by normo-, hyper- and hyporeactivity of the body after patch surgery.

患者および方法:

材料と方法：45歳から55歳で、II、III度の重症度、慢性経過の全身性歯周炎と診断された216人を調査した。生体の反応性の状態により、第1群は正常反応者、第2群は過反応者、第3群は低反応者から構成された3群に分けた。初回治療後の患者さんにはパッチテストを行いました。採血は術後1、2、4、6、9日目に行われた。赤血球のジエン酸抱合体，マロンアルデヒド，過酸化物溶血の含量，スーパーオキシドディスムターゼ活性，カタラーゼ，総抗酸化活性を生化学的手法により測定した．

PATIENTS AND METHODS: Materials and methods: 216 people aged 45 between 55 years with a diagnosis of generalized periodontitis of II, III degree of severity, chronic course were examined. Depending on the condition of reactivity of the organism, patients were divided into three groups: the first consisted of people with normoreaction; the second included patients with hyperreaction; the third group was made up by people with hyporeaction. Patients after initial therapy, underwent patch surgery. Blood sampling was performed after surgery on the 1st, 2nd, 4th, 6th and 9th day. The content of diene conjugates, malonic dialdehyde and peroxide hemolysis of erythrocytes, superoxide dismutase activity, catalase, and total antioxidant activity was determined by the biochemical method.

結果:

結果ノーマリアクションは、1日目と6日目に最大値を示し、観察終了時には酸化系のバランスが正常化する2相性の過酸化脂質の活性化によって特徴づけられた。高反応では、過酸化脂質の顕著な活性化（ジエン共役物質とマロンジアルデヒドの含有量の著しい増加、1日目に最大）と抗酸化防御活性の減退が典型的な例であった。低反応は、過酸化脂質の活性化が遅く（ジエン共役物質とマロンジアルデヒドの増加、4日目に最大）、抗酸化物質の活性が不十分であることが特徴であった。

RESULTS: Results: Normoreaction was characterized by two-phase moderate activation of lipid peroxidation with maxima on the 1st and 6th day against the normalization of the balance of oxidative systems by the end of observations. For hyperreaction pronounced activation of lipid peroxidation (significant increase in the content of diene conjugates and malonic dialdehyde with a maximum on the 1st day) accompanied by depletion of antioxidant protection activity was typical. Hyporeaction was characterized by slow activation of lipid peroxidation (increase in diene conjugates and malonic dialdehyde with a maximum on the 4th day) accompanied by insufficient activity of antioxidant protection.

結論:

結論全身性歯周炎患者において、身体の反応性の低下（亢進および低下）を伴うパラメーターの変化を修正し、正常な反応性の値に戻すことは、手術後の粘膜創傷治癒を最適化し、歯周組織をさらに安定させるための条件であると考えられる。

CONCLUSION: Conclusion: Correction of altered parameters in patients with generalized periodontitis accompanied by impaired (hyper- and hypo-) reactivity of the body with bringing them to values of normoreactivity is considered to be a condition for optimizing mucosal wound healing after surgery and further stabilization of the periodontal tissues.