フッ化ジアミン銀の黒色着色を低減するためのヨウ化カリウムの最適な濃度について

Optimal concentration of potassium iodide to reduce the black staining of silver diamine fluoride.

抄録

背景・目的:

ヨウ化カリウム（KI）は、フッ化ジアミン銀（SDF）塗布後に発生する黒色染色の程度を軽減するために使用されている。しかし、最適なKI濃度は未だ不明である。本研究では、SDF塗布後の黒色着色を効果的に低減させる最適なKI濃度を明らかにすることを目的とした。

BACKGROUND/PURPOSE: Potassium iodide (KI) is used for reducing the degree of black staining occurred after silver diamine fluoride (SDF) application. However, the optimal KI concentration remains unknown. This study aimed to identify the optimal concentration of KI that effectively reduces black staining after SDF application.

材料と方法:

う蝕のパターンが類似している24本の抜去歯を以下の6群に割り付けた。1) SDFのみ，2) SDF+7.5%KI，3) SDF+10%KI，4) SDF+15%KI，5) SDF+20%KI，6) SDF+saturated KI．の6群に分けた．KI溶液はSDF塗布後すぐに塗布した。SDF塗布前，SDF塗布直後，KI塗布直後，SDF+KI塗布1，3，7，14日後の各時点で歯の画像を取得し，色を測定した．写真は、ImageJプログラムを用いて、平均グレー値について分析した。

MATERIALS AND METHODS: Twenty-four extracted teeth with similar pattern of carious lesions were assigned into 6 groups as follows: 1) SDF only, 2) SDF+7.5%KI, 3) SDF+10%KI, 4) SDF+15%KI, 5) SDF+20%KI, and 6) SDF+saturated KI. The KI solution was applied immediately after SDF application. Tooth images were obtained for color measurement at different time points as followed; before SDF application, immediately after SDF application, immediately after KI application, 1, 3, 7 and 14 days after SDF+KI application. The photographs were analyzed for mean gray value using the ImageJ program.

結果:

KI塗布後、飽和KI群を除く各群は、用量依存的に有意な黒色染色の即時減少を示した。20%KI群では塗布直後から他群に比べΔ平均灰色値が最も高く，飽和KI群では塗布1日後から黒色着色の軽減がみられた．全群のΔmean gray値は経時的に減少した。7日後および14日後では，黒色染色の減少にKI群間の明確な差は認められなかった．

RESULTS: The KI groups demonstrated a dose-dependent significant immediate reduction in black staining after KI application, except the saturated KI group. The teeth in the 20% KI group had the highest Δ mean gray value compared with other groups immediately after KI application, whereas a reduction in black staining in the saturated KI group appeared 1 day after KI application. The Δ mean gray value in all groups decreased over time. After 7 and 14 days, the reduction in black staining was not clearly different between KI groups.

結論:

KI塗布は用量依存的に黒色染色の程度を低下させることができたが，その後の色調変化は14日間にわたりほとんど認められなかった．

CONCLUSION: KI application was able to reduce the degree of black staining in a dose-dependent manner, but the subsequent color change was minimal over the period of 14 days.