糖尿病性末梢神経障害の治療の進歩

Progress in the treatment of diabetic peripheral neuropathy.

抄録

糖尿病性末梢神経障害（DPN）は、糖尿病の最も一般的な慢性合併症の1つです。DPNの症状は主に、びまん性で継続的な自発的難治性疼痛を含み、数週間から数ヶ月間持続します。DPNは死亡率が高く、予後が悪いと言われています。その病態は完全には解明されておらず、臨床治療は臨床症状の緩和に加えて、血糖コントロールや心血管危険因子の改善に重点が置かれています。DPNとその臨床的に有効な治療法の研究が必要である。本研究では，DPNの治療法や病態について考察し，関連する研究の進捗状況をまとめ，DPN研究の参考にしようとするものである。

Diabetic peripheral neuropathy (DPN) is one of the most common chronic complications of diabetes. Symptoms of DPN mainly include spontaneous intractable pain that is diffuse and continuous and can last from several weeks to several months. DPN is associated with a high mortality rate and poor prognosis. Its pathogenesis is not fully understood, and clinical treatment is focused on relieving its clinical symptoms, as well as improving blood sugar control and cardiovascular risk factors. DPN and its clinically effective treatments need to be studied. This study discusses the treatment methods and pathogenesis of DPN, summarizes the related research progress, and attempts to provide a reference for DPN research.