抗喘息薬を服用している喘息患者の唾液

Salivary in asthmatic patients taking anti-asthmatic medication.

抄録

抗喘息薬は、口腔内を日和見感染症に侵されやすくし、口腔内感染症の原因となる。この研究は、抗喘息薬を服用している喘息患者の唾液を推定することを目的とした。2018年6月から2018年11月にかけて、インド、カルナータカ州、BidarにあるS.B. Patil Dental College and Hospitalの口腔病理・微生物科で前向き研究を行った。調査対象は、喘息患者50人と、喘息患者と年齢・性別を一致させた健常対照者50人の計100人であった。唾液は滅菌容器で5～10分間採取され、サンプルはコールドチェーン状態で研究室に移送された。唾液サンプルの連続希釈液を調製し、50：1の標準希釈液をSAD（Sabouraud Dextrose Agar）培地に芝生培養法で接種した。培養プレートの一部に菌を接種した。32人に発育がみられ、18人にはまったく発育がみられなかった。それぞれ18人が400CFU/ml群、32人が401CFU/ml群であった。400CFU/ml群では0.000、401CFU/ml群では27200であり、0.00が中央値であった。コロニー形成単位/mlでは、試験群と対照群で顕著な差がみられた（P=0.000）。喘息患者の増殖は健常人に比べて非常に高い。抗喘息薬は口腔内を日和見感染症に侵されやすくする。

Anti-asthmatic medication makes the oral habitat susceptible to opportunistic infections like , causing oral . This study aimed to estimate salivary in asthmatic patients taking anti-asthmatics medication. A prospective study was performed at the Oral Pathology and Microbiology Department of S.B. Patil Dental College and Hospital, Bidar, Karnataka, India, between June 2018 to November 2018. The research comprised a total of 100 individuals, 50 of whom were asthmatics, and 50 healthy controls who were age and sex-matched to the asthmatics. Saliva was collected for 5-10 minutes in a sterile container, and samples were transferred to the laboratory in cold chain conditions. Serial dilution was prepared for the saliva samples, and 50:1 standard dilution was inoculated on SAD (Sabouraud Dextrose Agar) culture media by lawn culture method. Some part of the culture plate was inoculated with organisms. 32 people had growth, and 18 individuals did not have any development at all. 18 people were in the 400 CFU/ml group, and 32 individuals were in the 401 CFU/ml group, respectively. It was 0.000 in the 400 colony forming unit/milliliter group, and 27200 in the 401 CFU/ml group, with 0.00 being the median. There was a notable difference between study and control groups in terms of colony forming unit per milliliter (P=0.000). The growth of in asthmatics patients is very high compared to healthy people. Anti-asthmatic medication makes the oral habitat prone to attack from opportunistic infections like oral .