放射線治療中の上咽頭がん患者における健康関連体力およびQOLに及ぼす複合的運動の効果

Effects of Multimodal Exercise on Health-related Physical Fitness and Quality of Life in Patients with Nasopharyngeal Carcinoma during Radiotherapy.

抄録

背景:

上咽頭がん患者の健康関連体力は放射線療法中に著しく低下し、QOLに悪影響を及ぼす可能性がある。

BACKGROUND: The health-related physical fitness of patients with nasopharyngeal carcinoma can decrease significantly during radiotherapy, which can adversely affect their quality of life.

目的:

本研究は、放射線療法中の上咽頭がん患者の健康関連体力およびQOLに及ぼす、複合的運動プログラムの潜在的影響を評価するために計画された。

AIM: This study was designed to evaluate the potential influence of a multimodal exercise program on the health-related physical fitness and quality of life of patients with nasopharyngeal carcinoma during radiotherapy.

方法:

2019年5月から11月にかけて福建医科大学第一付属病院で放射線治療を受けた上咽頭がん患者40名を対象とした。対照群（N=20）は日常的な看護を受け、介入群（N=20）は放射線治療中にマルチモーダル運動プログラムも受けた。

METHODS: Forty patients with nasopharyngeal carcinoma undergoing radiotherapy in the First Affiliated Hospital of Fujian Medical University from May to November 2019 were included. The participants in the control group (N=20) received routine nursing, while those in the intervention group (N=20) were also subjected to the multimodal exercise program during radiotherapy.

結果:

多動的運動プログラムは参加者に肯定的な効果をもたらした。介入群のステップテスト指数は対照群と比較して有意に高かった（p < 0.05）。低速（60°/s）5回、高速（180°/s）10回を行ったところ、介入群では肘関節、肩関節、膝関節の伸筋、屈筋の機能が著しく改善した（p < 0.05）。介入群では、右手の握力が有意に改善した（p < .01）。さらに、介入群の上肢背掻テストは対照群より有意に良好であった（p＜0.05）。介入群の身体的機能、情緒的機能、社会的機能のスコアは、対照群と比較して有意に高いことが認められた（p＜0.05）。

RESULTS: The multimodal exercise program had a positive effect on participants. The step test index in the intervention group was significantly higher as compared to the control group (p < .05). The participants were subjected to 5 times slow speed (60°/s) and 10 times fast (180°/s) speed, and function of some extensor and flexor muscles of the elbow, shoulder, and knee joints in the intervention group was markedly improved (p < .05). In the intervention group, the grip strength of the right hand was observed to be significantly improved (p < .01). Furthermore, the upper limb scratch dorsal test of intervention group was significantly better than that of the control group (p < .05). The scores of physical, emotional, and social functions in the intervention group were found to be significantly higher as compared to the control group (p < .05).

結論:

マルチモーダル運動プログラムは、放射線治療中の上咽頭がん患者の健康関連体力および生活の質を有意に改善したが、その長期的効果についてはさらなる解析が必要である。

CONCLUSIONS: The multimodal exercise program significantly improved the health-related physical fitness and life quality of the patients with nasopharyngeal carcinoma during radiotherapy, though its long-term effects remain to be further analyzed.