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重度歯周炎骨欠損に対する豚コラーゲン膜＋人工牛骨顆粒誘導組織再生と自家CGF併用療法の臨床的検討
Clinical observation of Porcine Collagen Membrane + artificial Bovine Bone Granules Guided tissue regeneration combined with Autologous CGF in the treatment of severe periodontitis bone defect.
PMID: 37250558
抄録
目的:
重度歯周炎骨欠損に対する豚コラーゲン膜＋人工牛骨顆粒併用組織再生誘導法（GTR）と自家CGF（成長因子濃度）の臨床観察結果を調査・解析する。
OBJECTIVE: To investigate and analyze the clinical observation of porcine collagen membrane + artificial bovine bone granules guided tissue regeneration (GTR) combined with autologous concentration of growth factors (CGF) in the treatment of severe periodontitis bone defect.
方法:
2019年1月から2022年1月までに山西ベスーン病院に入院した重度歯周炎骨欠損患者94名を対象とした。単純無作為化法により2群に分けた。対照群の患者には豚コラーゲン膜＋人工牛骨顆粒GTRによる治療を行い、観察群の患者には対照群を基本として自家CGFによる治療を行った。治療前後に歯周臨床指標［溝出血指数（SBI）、歯肉退縮指数（GR）、プロービングデプス（PD）、臨床的アタッチメントロス（CAL）、歯槽骨高さ（AH）］および骨吸収マーカー［オステオプロテジェリン（OPG）、骨glaプロテイン（BGP）、Type-1コラーゲンN末端ペプチド（NTX）］を両群間で比較し、両群における術後合併症の発生率を記録した。
METHODS: A total of 94 patients with severe periodontitis bone defects admitted to Shanxi Bethune Hospital from January 2019 to January 2022 were included. They were divided into two groups by simple randomization method. Patients in the control group were treated with porcine collagen membrane + artificial bovine bone granules GTR, while those in the observation group were treated with autologous CGF on the basis of the control group. Before and after treatment, periodontal clinical indicators [sulcus bleeding index (SBI), gingival retreat index (GR), probing depth (PD), clinical attachment loss (CAL), alveolar bone height (AH)] and bone resorption markers [Osteoprotegerin (OPG), bone gla protein (BGP), Type-1 collagen N-terminal peptide (NTX)] were compared between the two groups, and the incidence of postoperative complications in the two groups was recorded.
結果:
観察群の有効性は対照群より有意に高かった（0.05）。術後3ヵ月後、観察群は対照群よりSBI、PD、CAL、NTXが低く、GR、AH、OPG、BGPが高かった（0.05）。合併症発生率は両群間に有意差はなかった（0.05）。
RESULTS: The total efficacy of observation group was significantly higher than that of control group (0.05). Three months after surgery, the observation group had lower levels of SBI, PD, CAL and NTX while higher levels of GR, AH, OPG and BGP than the control group (0.05). There was no significant difference in complication rate between the two groups (0.05).
結論:
豚コラーゲン膜＋牛人工骨顆粒 GTR と自家 CGF の併用は，重度歯周炎骨欠損の治療において，臨床転帰の改善，歯周組織の改善，骨吸収の抑制など，さまざまな有用性を示した．
CONCLUSION: Porcine collagen membrane + artificial bovine bone granules GTR combined with autologous CGF boasts various benefits in the treatment of severe periodontitis bone defects, such as improvement of clinical outcomes, amelioration of periodontal tissue and inhibition of bone resorption.