薬剤性舌障害：包括的文献レビュー

Drug-induced Tongue Disorders: A Comprehensive Literature Review.

抄録

背景:

薬物の中には、副作用として舌障害を引き起こすものがある。薬剤性舌障害の多くは良性であり、薬剤の中止により消失する。しかし、舌の色や見た目の変化は患者を恐怖に陥れ、薬物療法のコンプライアンスを低下させる可能性がある。

BACKGROUND: Some drugs cause tongue disorders as adverse effects. Most of the druginduced tongue disorders are benign and will resolve after drug discontinuation. However, the changes in the color or appearance of the tongue may frighten patients and decrease compliance with drug therapy.

目的:

薬物誘発性舌障害のすべての報告、そのプレゼンテーション、管理、および患者の転帰を見つけるために文献をレビューすること 方法Google ScholarおよびPubMedにおいて、"ageusia"、"burning tongue"、"coated tongue"、"drug-induced taste disturbance"、"dysgeusia"、"glossitis"、"glossodynia"、"hairy tongue"、"hypogeusia"、"stomatodynia"、"stomatopyrosis"、"swollen tongue"、"tongue discoloration"、"tongue irritation"、"tongue numbness"、"tongue oedema"、"tongue ulcer "をキーワードとして検索を行った。1980年から2022年までに英語で発表されたすべての報告が研究の対象となった。英語ではないが、抽出に十分なデータを含む英語の抄録がある報告も対象とした。

OBJECTIVE: To review the literature to find all reports of drug-induced tongue disorders, their presentation, management, and outcome of patients Methods: The search was conducted in Google Scholar and PubMed using key words "ageusia," "burning tongue," "coated tongue," "drug-induced taste disturbances," "dysgeusia," "glossitis," "glossodynia," "hairy tongue," "hypogeusia," "stomatodynia," "stomatopyrosis," "swollen tongue" "tongue discoloration," "tongue irritation," "tongue numbness, "tongue oedema," and "tongue ulcer. All reports that were published from 1980 to 2022 in the English language were included in the study. Reports that were not in English language but had English abstracts with adequate data for extraction were also included.

結果:

合計208件の症例報告および症例シリーズが対象となった。最も多く報告された薬剤クラスは抗悪性腫瘍薬、免疫調節薬、全身用抗感染症薬であり、最も多く報告された舌障害は舌の変色と黒毛舌であった。口腔衛生を良好に保ち、原因薬剤を中止することで、問題を管理し解決することができた。

RESULTS: A total of 208 case reports and case series were included. The most reported drug classes were antineoplastic and immunomodulating agents and anti-infectives for systemic use, and the most common tongue disorders were tongue discoloration and black hairy tongue. Having good oral hygiene and discontinuing the offending drug could manage and resolve the problem.

結論:

薬剤性舌障害はまれな副作用ではない。ほとんどの症例で良性であり、原因薬剤を中止することにより、舌病変は有意に改善または完全に消失する。

CONCLUSION: Drug-induced tongue disorders are not rare adverse drug reactions. They are benign in most cases, and withholding offending agents results in significant improvement or complete resolution of tongue lesions.