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日本語AIでPubMedを検索

日本語AIでPubMedを検索

PubMedの提供する医学論文データベースを日本語で検索できます。AI(Deep Learning)を活用した機械翻訳エンジンにより、精度高く日本語へ翻訳された論文をご参照いただけます。

2020年07月 みんなが読んでいる論文

アロステリックおよびATP競合的なmTORの阻害剤は、Tsc2マウスの腎臓における腫瘍の進行と上皮-間葉系転移を効果的に抑制する

Allosteric and ATP-Competitive Inhibitors of mTOR Effectively Suppress Tumor Progression-Associated Epithelial-Mesenchymal Transition in the Kidneys of Tsc2 Mice.
  • Ashley T Jones
  • Jian Yang
  • Kalin Narov
  • Elizabeth P Henske
  • Julian R Sampson
  • Ming Hong Shen
  • Neoplasia.2019 08;21(8):731-739. S1476-5586(19)30148-4. doi: 10.1016/j.neo.2019.05.003.Epub 2019-06-14.

ジャスモン酸メチルは、モノアミン神経伝達、抗酸化防御システム、Nrf2発現の調節を介して、慢性的なストレス誘発性の記憶機能障害を逆転させる

Methyl jasmonate reverses chronic stress-induced memory dysfunctions through modulation of monoaminergic neurotransmission, antioxidant defense system, and Nrf2 expressions.
  • Oritoke M Aluko
  • Solomon Umukoro
  • Naunyn Schmiedebergs Arch. Pharmacol..2020 Jul;10.1007/s00210-020-01939-6. doi: 10.1007/s00210-020-01939-6.Epub 2020-07-14.

ポリエチレンマイクロプラスチックに曝露されたスクラクチンサンゴの生理的ストレス応答(英文

Physiological stress response of the scleractinian coral Stylophora pistillata exposed to polyethylene microplastics.
  • Chantal M Lanctôt
  • Vanessa N Bednarz
  • Steven Melvin
  • Hugo Jacob
  • François Oberhaensli
  • Peter W Swarzenski
  • Christine Ferrier-Pagès
  • Anthony R Carroll
  • Marc Metian
  • Environ. Pollut..2020 Aug;263(Pt A):114559. S0269-7491(19)36710-7. doi: 10.1016/j.envpol.2020.114559.Epub 2020-04-12.

SCREENED.甲状腺機能の多段階モデルを用いて、生物学的に性別に特化した方法で内分泌かく乱物質をスクリーニングする

SCREENED: A Multistage Model of Thyroid Gland Function for Screening Endocrine-Disrupting Chemicals in a Biologically Sex-Specific Manner.
  • Lorenzo Moroni
  • Fulvio Barbaro
  • Florian Caiment
  • Orla Coleman
  • Sabine Costagliola
  • Giusy Di Conza
  • Lisa Elviri
  • Stefan Giselbrecht
  • Christian Krause
  • Carlos Mota
  • Marta Nazzari
  • Stephen R Pennington
  • Annette Ringwald
  • Monica Sandri
  • Simon Thomas
  • James Waddington
  • Roberto Toni
  • Int J Mol Sci.2020 May;21(10). E3648. doi: 10.3390/ijms21103648.Epub 2020-05-21.

セリアック病の病原性ペプチドに対する加水分解活性を向上させたスフィンゴモナス・カプシュラータ由来のプロリルエンドペプチダーゼを合理的に設計した

Rationally engineered prolyl endopeptidases from Sphingomonas capsulata with improved hydrolytic activity towards pathogenic peptides of celiac diseases.
  • Bin Xiao
  • Chun Zhang
  • Xiaotong Song
  • Miao Wu
  • Jianping Mao
  • Rong Yu
  • Yongxiang Zheng
  • Eur J Med Chem.2020 Jul;202:112499. S0223-5234(20)30471-2. doi: 10.1016/j.ejmech.2020.112499.Epub 2020-07-06.

放射光フーリエ変換赤外顕微分光法を用いた慢性アレルギー性気道疾患のマウスモデルにおける実験化合物の分子機構の解明

Investigation of molecular mechanisms of experimental compounds in murine models of chronic allergic airways disease using synchrotron Fourier-transform infrared microspectroscopy.
  • Nadia Mazarakis
  • Jitraporn Vongsvivut
  • Keith R Bambery
  • Katherine Ververis
  • Mark J Tobin
  • Simon G Royce
  • Chrishan S Samuel
  • Kenneth J Snibson
  • Paul V Licciardi
  • Tom C Karagiannis
  • Sci Rep.2020 Jul;10(1):11713. 10.1038/s41598-020-68671-2. doi: 10.1038/s41598-020-68671-2.Epub 2020-07-16.

5年間のレトロスペクティブ研究により、カーボベルデでは黄色ブドウ球菌と大腸菌の両方で抗菌薬耐性が増加していることが示された

A five-year retrospective study shows increasing rates of antimicrobial drug resistance in Cabo Verde for both Staphylococcus aureus and Escherichia coli.
  • Tamar Monteiro
  • Magdalena Wysocka
  • Elena Tellez
  • Ofelia Monteiro
  • Luzia Spencer
  • Elisa Veiga
  • Sandra Monteiro
  • Carine de Pina
  • Deisy Gonçalves
  • Sandrine de Pina
  • Antonio Ludgero-Correia
  • Joao Moreno
  • Teresa Conceição
  • Marta Aires De Sousa
  • Herminia de Lencastre
  • Laura J Gray
  • Manish Pareek
  • David R Jenkins
  • Sandra Beleza
  • Marco R Oggioni
  • Isabel Inês Araujo
  • J Glob Antimicrob Resist.2020 Apr;22:483-487. S2213-7165(20)30094-1. doi: 10.1016/j.jgar.2020.04.002.Epub 2020-04-27.

石英光音響分光法を用いて検出された混合物中のガス濃度を取得するためのツールとしての部分最小二乗回帰

Partial least squares regression as a tool to retrieve gas concentrations in mixtures detected by using quartz-enhanced photoacoustic spectroscopy.
  • Andrea Zifarelli
  • Marilena Giglio
  • Giansergio Menduni
  • Angelo Sampaolo
  • Pietro Patimisco
  • Vittorio M N Passaro
  • Hongpeng Wu
  • Lei Dong
  • Vincenzo Spagnolo
  • Anal. Chem..2020 Jul;doi: 10.1021/acs.analchem.0c00075.Epub 2020-07-17.

深層畳み込みニューラルネットワークベースのソフトウェアは、胸部X線写真上の悪性肺結節の放射線技師による検出を改善する

Deep Convolutional Neural Network-based Software Improves Radiologist Detection of Malignant Lung Nodules on Chest Radiographs.
  • Yongsik Sim
  • Myung Jin Chung
  • Elmar Kotter
  • Sehyo Yune
  • Myeongchan Kim
  • Synho Do
  • Kyunghwa Han
  • Hanmyoung Kim
  • Seungwook Yang
  • Dong-Jae Lee
  • Byoung Wook Choi
  • Radiology.2020 01;294(1):199-209. doi: 10.1148/radiol.2019182465.Epub 2019-11-12.

miR319を標的としたGhTCP4は、綿繊維の細胞伸長から細胞壁の肥厚への移行を促進する

The miR319-Targeted GhTCP4 Promotes the Transition from Cell Elongation to Wall Thickening in Cotton Fiber.
  • Jun-Feng Cao
  • Bo Zhao
  • Chao-Chen Huang
  • Zhi-Wen Chen
  • Ting Zhao
  • Hong-Ru Liu
  • Guan-Jing Hu
  • Xiao-Xia Shangguan
  • Chun-Min Shan
  • Ling-Jian Wang
  • Tian-Zhen Zhang
  • Jonathan F Wendel
  • Xue-Ying Guan
  • Xiao-Ya Chen
  • Mol Plant.2020 Jul;13(7):1063-1077. S1674-2052(20)30141-6. doi: 10.1016/j.molp.2020.05.006.Epub 2020-05-16.

2cm未満の腎/尿管結石の治療を目的とした2つの低侵襲手技の直接/間接コストの比較分析

Comparative analysis of direct and indirect costs of two minimally invasive techniques for the treatment of renal/ureteral calculi smaller than 2 cm.
  • J Perez-Ardavin
  • L Lorenzo
  • V Caballer-Tarazona
  • A Budía-Alba
  • D Vivas-Consuelo
  • P Bahilo-Mateu
  • G Ordaz-Jurado
  • M Trassierra-Villa
  • J D López-Acón
  • F Boronat-Tormo
  • Actas Urol Esp.2020 Jun;S0210-4806(20)30080-2. doi: 10.1016/j.acuro.2020.03.008.Epub 2020-06-24.

切除不能または転移性の悪性末梢神経鞘腫瘍患者を対象としたパゾパニブの第Ⅱ相臨床試験

Phase II clinical trial of pazopanib for patients with unresectable or metastatic malignant peripheral nerve sheath tumors.
  • Yoshihiro Nishida
  • Hiroshi Urakawa
  • Robert Nakayama
  • Eisuke Kobayashi
  • Toshifumi Ozaki
  • Keisuke Ae
  • Yoshihiro Matsumoto
  • Hiroyuki Tsuchiya
  • Takahiro Goto
  • Hiroaki Hiraga
  • Norifumi Naka
  • Shunji Takahashi
  • Yuichi Ando
  • Masahiko Ando
  • Yachiyo Kuwatsuka
  • Shunsuke Hamada
  • Takafumi Ueda
  • Akira Kawai
  • Int. J. Cancer.2020 Jul;doi: 10.1002/ijc.33201.Epub 2020-07-07.

脂肪アシル鎖の長さとアシル化部位のアシルトランスフェラーゼによる選択が、細菌のRTX毒素の活性化に関与していることが明らかになった

Acyltransferase-mediated selection of the length of the fatty acyl chain and of the acylation site governs activation of bacterial RTX toxins.
  • Adriana Osickova
  • Humaira Khaliq
  • Jiri Masin
  • David Jurnecka
  • Anna Sukova
  • Radovan Fiser
  • Jana Holubova
  • Ondrej Stanek
  • Peter Sebo
  • Radim Osicka
  • J. Biol. Chem..2020 Jul;295(28):9268-9280. RA120.014122. doi: 10.1074/jbc.RA120.014122.Epub 2020-05-27.

β細胞の成熟期と糖尿病の代謝可塑性を支えるmTORC1からAMPKへのスイッチング

mTORC1 to AMPK switching underlies β-cell metabolic plasticity during maturation and diabetes.
  • Rami Jaafar
  • Stella Tran
  • Ajit N Shah
  • Gao Sun
  • Martin Valdearcos
  • Piero Marchetti
  • Matilde Masini
  • Avital Swisa
  • Simone Giacometti
  • Ernesto Bernal-Mizrachi
  • Aleksey Matveyenko
  • Matthias Hebrok
  • Yuval Dor
  • Guy A Rutter
  • Suneil K Koliwad
  • Anil Bhushan
  • J. Clin. Invest..2019 07;129(10):4124-4137. 127021. doi: 10.1172/JCI127021.Epub 2019-07-02.

転移性非小細胞肺がん患者とその配偶者に対する支持的ケア戦略としてのマインドフルネスに基づく介入.3アームのパイロット無作為化対照試験の結果

A Mindfulness-Based Intervention as a Supportive Care Strategy for Patients with Metastatic Non-Small Cell Lung Cancer and their Spouses: Results of a 3-Arm Pilot Randomized Controlled Trial.
  • Kathrin Milbury
  • Yisheng Li
  • Sania Durrani
  • Zhongxing Liao
  • Anne S Tsao
  • Cindy Carmack
  • Lorenzo Cohen
  • Eduardo Bruera
  • Oncologist.2020 Jul;doi: 10.1634/theoncologist.2020-0125.Epub 2020-07-04.

生のココナッツコアーと綿、廃バガス、木材、竹の粉砕粉末をホットプレスして調製した植物繊維ベースのバイオポリマーの機械的、熱的、構造的特性に関するデータセット

Dataset on mechanical, thermal and structural characterization of plant fiber-based biopolymers prepared by hot-pressing raw coconut coir, and milled powders of cotton, waste bagasse, wood, and bamboo.
  • Mohammed Abdullah Hamad Alharbi
  • Shinji Hirai
  • Hoang Anh Tuan
  • Shota Akioka
  • Wataru Shoji
  • Data Brief.2020 Jun;30:105510. S2352-3409(20)30404-2. doi: 10.1016/j.dib.2020.105510.Epub 2020-04-21.

ホルモン感受性前立腺癌のリュープロレリン治療を受けた被験者の集団疾患進行モデルを開発するために、医療請求書データベースを使用しています

Using medical claims database to develop a population disease progression model for leuprorelin-treated subjects with hormone-sensitive prostate cancer.
  • Yixuan Zou
  • Fei Tang
  • Jeffery C Talbert
  • Chee M Ng
  • PLoS ONE.2020;15(3):e0230571. PONE-D-19-27455. doi: 10.1371/journal.pone.0230571.Epub 2020-03-24.

ケニアの女性性労働者のための携帯電話をベースとした性と生殖の健康のための介入。開発と質的研究

A Mobile Phone-Based Sexual and Reproductive Health Intervention for Female Sex Workers in Kenya: Development and Qualitative Study.
  • Frances H Ampt
  • Kelly L'Engle
  • Megan S C Lim
  • Kate F Plourde
  • Emily Mangone
  • Collins Mudogo Mukanya
  • Peter Gichangi
  • Griffins Manguro
  • Margaret Hellard
  • Mark Stoové
  • Matthew F Chersich
  • Walter Jaoko
  • Paul A Agius
  • Marleen Temmerman
  • Winnie Wangari
  • Stanley Luchters
  • JMIR Mhealth Uhealth.2020 May;8(5):e15096. v8i5e15096. doi: 10.2196/15096.Epub 2020-05-29.

脱髄後の脂質誘導リソソーム損傷はリソソーム貯蔵障害のミクログリア保護機能を壊す

Lipid-induced lysosomal damage after demyelination corrupts microglia protective function in lysosomal storage disorders.
  • Enrique Gabandé-Rodríguez
  • Azucena Pérez-Cañamás
  • Beatriz Soto-Huelin
  • Daniel N Mitroi
  • Sara Sánchez-Redondo
  • Elena Martínez-Sáez
  • César Venero
  • Héctor Peinado
  • María Dolores Ledesma
  • EMBO J..2019 01;38(2). e99553. doi: 10.15252/embj.201899553.Epub 2018-12-07.

膀胱癌細胞におけるラパマイシン複合体2の哺乳類標的によるカベオリン-1のリン酸化とカベオリン形成の動的制御

Dynamic Regulation of Caveolin-1 Phosphorylation and Caveolae Formation by Mammalian Target of Rapamycin Complex 2 in Bladder Cancer Cells.
  • Andrew M Hau
  • Sounak Gupta
  • Mariah Z Leivo
  • Kazufumi Nakashima
  • Jesus Macias
  • Weidong Zhou
  • Alex Hodge
  • Julie Wulfkuhle
  • Brian Conkright
  • Krithika Bhuvaneshwar
  • Shruti Rao
  • Subha Madhavan
  • Emanuel F Petricoin
  • Donna E Hansel
  • Am. J. Pathol..2019 09;189(9):1846-1862. S0002-9440(19)30079-3. doi: 10.1016/j.ajpath.2019.05.010.Epub 2019-06-11.

内腔乳癌細胞におけるMKL1の核内蓄積はERαのゲノム活性を低下させ、内分泌抵抗性と関連しています

Nuclear accumulation of MKL1 in luminal breast cancer cells impairs genomic activity of ERα and is associated with endocrine resistance.
  • Charly Jehanno
  • Tamara Fernandez-Calero
  • Denis Habauzit
  • Stephane Avner
  • Frederic Percevault
  • Emmanuelle Jullion
  • Pascale Le Goff
  • Marie May Coissieux
  • Simone Muenst
  • Monica Marin
  • Denis Michel
  • Raphaël Métivier
  • Gilles Flouriot
  • Biochim Biophys Acta Gene Regul Mech.2020 05;1863(5):194507. S1874-9399(19)30462-6. doi: 10.1016/j.bbagrm.2020.194507.Epub 2020-02-27.

Netrin-1はWntとMAPKシグナルのNeo1とUnc5bの共調節を介してナイーブな多能性を促進する

Netrin-1 promotes naive pluripotency through Neo1 and Unc5b co-regulation of Wnt and MAPK signalling.
  • Aurélia Huyghe
  • Giacomo Furlan
  • Duygu Ozmadenci
  • Christina Galonska
  • Jocelyn Charlton
  • Xavier Gaume
  • Noémie Combémorel
  • Christina Riemenschneider
  • Nicolas Allègre
  • Jenny Zhang
  • Pauline Wajda
  • Nicolas Rama
  • Pauline Vieugué
  • Isabelle Durand
  • Marie Brevet
  • Nicolas Gadot
  • Thomas Imhof
  • Bradley J Merrill
  • Manuel Koch
  • Patrick Mehlen
  • Claire Chazaud
  • Alexander Meissner
  • Fabrice Lavial
  • Nat. Cell Biol..2020 04;22(4):389-400. 10.1038/s41556-020-0483-2. doi: 10.1038/s41556-020-0483-2.Epub 2020-03-30.

Pileostegia tomentella (ZLTE)の酢酸エチル抽出物は、活性酸素誘導性アポトーシスを介してH1299細胞に抗がん作用を発揮します

The ethyl acetate extraction of Pileostegia tomentella (ZLTE) exerts anti-cancer effects on H1299 cells via ROS-induced canonical apoptosis.
  • Qiu-Mei Fan
  • Wen-Tong Zhao
  • Renyikun Yuan
  • Qin-Qin Wang
  • Li-Feng Zhang
  • Hong-Wei Gao
  • Jing Leng
  • Shi-Lin Yang
  • Chin J Nat Med.2020 Jul;18(7):508-516. S1875-5364(20)30061-3. doi: 10.1016/S1875-5364(20)30061-3.

パーソナライズされた分散型患者指導システムの評価

Assessment of a personalized and distributed patient guidance system.
  • Mor Peleg
  • Yuval Shahar
  • Silvana Quaglini
  • Tom Broens
  • Roxana Budasu
  • Nick Fung
  • Adi Fux
  • Gema García-Sáez
  • Ayelet Goldstein
  • Arturo González-Ferrer
  • Hermie Hermens
  • M Elena Hernando
  • Val Jones
  • Guy Klebanov
  • Denis Klimov
  • Daniel Knoppel
  • Nekane Larburu
  • Carlos Marcos
  • Iñaki Martínez-Sarriegui
  • Carlo Napolitano
  • Àngels Pallàs
  • Angel Palomares
  • Enea Parimbelli
  • Belén Pons
  • Mercedes Rigla
  • Lucia Sacchi
  • Erez Shalom
  • Pnina Soffer
  • Boris van Schooten
  • Int J Med Inform.2017 05;101:108-130. S1386-5056(17)30049-7. doi: 10.1016/j.ijmedinf.2017.02.010.Epub 2017-02-21.

舌の診断における人工知能深層畳み込みニューラルネットワークを用いた歯牙痕のある不健康な舌の認識

Artificial intelligence in tongue diagnosis: Using deep convolutional neural network for recognizing unhealthy tongue with tooth-mark.
  • Xu Wang
  • Jingwei Liu
  • Chaoyong Wu
  • Junhong Liu
  • Qianqian Li
  • Yufeng Chen
  • Xinrong Wang
  • Xinli Chen
  • Xiaohan Pang
  • Binglong Chang
  • Jiaying Lin
  • Shifeng Zhao
  • Zhihong Li
  • Qingqiong Deng
  • Yi Lu
  • Dongbin Zhao
  • Jianxin Chen
  • Comput Struct Biotechnol J.2020;18:973-980. S2001-0370(20)30032-5. doi: 10.1016/j.csbj.2020.04.002.Epub 2020-04-08.