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日本語AIでPubMedを検索

日本語AIでPubMedを検索

PubMedの提供する医学論文データベースを日本語で検索できます。AI(Deep Learning)を活用した機械翻訳エンジンにより、精度高く日本語へ翻訳された論文をご参照いただけます。

みんなが読んでいる論文

広範囲な病変の偏析ががんゲノムの進化を形作る

Pervasive lesion segregation shapes cancer genome evolution.
  • Sarah J Aitken
  • Craig J Anderson
  • Frances Connor
  • Oriol Pich
  • Vasavi Sundaram
  • Christine Feig
  • Tim F Rayner
  • Margus Lukk
  • Stuart Aitken
  • Juliet Luft
  • Elissavet Kentepozidou
  • Claudia Arnedo-Pac
  • Sjoerd V Beentjes
  • Susan E Davies
  • Ruben M Drews
  • Ailith Ewing
  • Vera B Kaiser
  • Ava Khamseh
  • Erika López-Arribillaga
  • Aisling M Redmond
  • Javier Santoyo-Lopez
  • Inés Sentís
  • Lana Talmane
  • Andrew D Yates
  • Colin A Semple
  • Núria López-Bigas
  • Paul Flicek
  • Duncan T Odom
  • Martin S Taylor
  • Nature.2020 07;583(7815):265-270. 10.1038/s41586-020-2435-1. doi: 10.1038/s41586-020-2435-1.Epub 2020-06-24.

経皮的冠動脈インターベンション後の急性冠症候群患者におけるマルチジーン薬理遺伝学的検査の費用対効果.

Cost-Effectiveness of Multigene Pharmacogenetic Testing in Patients With Acute Coronary Syndrome After Percutaneous Coronary Intervention.
  • Olivia M Dong
  • Stephanie B Wheeler
  • Gracelyn Cruden
  • Craig R Lee
  • Deepak Voora
  • Stacie B Dusetzina
  • Tim Wiltshire
  • Value Health.2020 01;23(1):61-73. S1098-3015(19)32344-7. doi: 10.1016/j.jval.2019.08.002.Epub 2019-09-25.

トリプルネガティブ乳癌に対する MR/蛍光イメージングおよび強化された光力学的治療のためのフィブロネクチン標的化およびカテプシン B 活性化可能な治療法ナノプローブ

Fibronectin-Targeting and Cathepsin B-Activatable Theranostic Nanoprobe for MR/Fluorescence Imaging and Enhanced Photodynamic Therapy for Triple Negative Breast Cancer.
  • Yanshu Wang
  • Liping Jiang
  • Yuwen Zhang
  • Yimei Lu
  • Jinning Li
  • He Wang
  • Defan Yao
  • Dengbin Wang
  • ACS Appl Mater Interfaces.2020 Jul;doi: 10.1021/acsami.0c10397.Epub 2020-07-20.

BRCA 変異キャリアにおけるラジオミクスと機械学習を用いた MRI 上のセンチ以下の増強乳房腫瘤の特徴付けの改善

Improved characterization of sub-centimeter enhancing breast masses on MRI with radiomics and machine learning in BRCA mutation carriers.
  • Roberto Lo Gullo
  • Isaac Daimiel
  • Carolina Rossi Saccarelli
  • Almir Bitencourt
  • Peter Gibbs
  • Michael J Fox
  • Sunitha B Thakur
  • Danny F Martinez
  • Maxine S Jochelson
  • Elizabeth A Morris
  • Katja Pinker
  • Eur Radiol.2020 Jun;10.1007/s00330-020-06991-7. doi: 10.1007/s00330-020-06991-7.Epub 2020-06-27.

リン酸ナトリウムの経口負荷が非正常および高カルシウム血症の結石形成患者における副甲状腺ホルモンおよび線維芽細胞増殖因子23の分泌に及ぼす影響

The effect of an oral sodium phosphate load on parathyroid hormone and fibroblast growth factor 23 secretion in normo- and hypercalciuric stone-forming patients.
  • Tomasz Irzyniec
  • Monika Boryń
  • Joanna Kasztalska
  • Zofia Nowak-Kapusta
  • Izabela Maciejewska-Paszek
  • Elżbieta Grochowska-Niedworok
  • Clin Nutr.2020 Apr;S0261-5614(20)30191-6. doi: 10.1016/j.clnu.2020.04.020.Epub 2020-04-21.

非小細胞肺がんに対するユニポータルビデオ支援胸部外科的葉切除術後の胸膜ドレナージ量の予測因子:単施設レトロスペクティブ研究

Predictive factors for pleural drainage volume after uniportal video-assisted thoracic surgery lobectomy for non-small cell lung cancer: a single-institution retrospective study.
  • Ming-Bo Tang
  • Jia-Lin Li
  • Su-Yan Tian
  • Xin-Liang Gao
  • Wei Liu
  • World J Surg Oncol.2020 Jul;18(1):162. 10.1186/s12957-020-01941-5. doi: 10.1186/s12957-020-01941-5.Epub 2020-07-08.

血液脳関門における差異発現は、AAV-PHP.B.の菌株特異的中枢神経系トランスダクションプロファイルに責任がある

Differential Expression in Blood-Brain Barrier Is Responsible for Strain Specific Central Nervous System Transduction Profile of AAV-PHP.B.
  • Ana Rita Batista
  • Oliver D King
  • Christopher P Reardon
  • Crystal Davis
  • Shankaracharya
  • Vivek Philip
  • Heather Gray-Edwards
  • Neil Aronin
  • Cathleen Lutz
  • John Landers
  • Miguel Sena-Esteves
  • Hum. Gene Ther..2020 Jan;31(1-2):90-102. doi: 10.1089/hum.2019.186.Epub 2019-12-13.

MnO粉末による低線量放射線被曝はラットの精巣と前立腺の遺伝子発現を変化させる

Low-Dose Radiation Exposure with MnO Powder Changes Gene Expressions in the Testes and the Prostate in Rats.
  • Nariaki Fujimoto
  • Gaukhar Amantayeva
  • Nailya Chaizhunussova
  • Dariya Shabdarbayeva
  • Zhaslan Abishev
  • Bakhyt Ruslanova
  • Yersin Zhunussov
  • Almas Azhimkhanov
  • Kassym Zhumadilov
  • Aleksey Petukhov
  • Valeriy Stepanenko
  • Masaharu Hoshi
  • Int J Mol Sci.2020 Jul;21(14). E4989. doi: 10.3390/ijms21144989.Epub 2020-07-15.

進化的解析により、イネL-ミオイノシトール1リン酸合成酵素の触媒活性に不可欠な2つのリジン残基を含む保存されたペンタペプチド配列が同定された

An evolutionary analysis identifies a conserved pentapeptide stretch containing the two essential lysine residues for rice L-myo-inositol 1-phosphate synthase catalytic activity.
  • Papri Basak
  • Susmita Maitra-Majee
  • Jayanta Kumar Das
  • Abhishek Mukherjee
  • Shubhra Ghosh Dastidar
  • Pabitra Pal Choudhury
  • Arun Lahiri Majumder
  • PLoS ONE.2017;12(9):e0185351. PONE-D-17-03012. doi: 10.1371/journal.pone.0185351.Epub 2017-09-26.

選択的消化管除染を受けた集中治療患者と健常者の腸内細菌叢とレジストームプロファイリングの比較

Comparative gut microbiota and resistome profiling of intensive care patients receiving selective digestive tract decontamination and healthy subjects.
  • Elena Buelow
  • Teresita D J Bello González
  • Susana Fuentes
  • Wouter A A de Steenhuijsen Piters
  • Leo Lahti
  • Jumamurat R Bayjanov
  • Eline A M Majoor
  • Johanna C Braat
  • Maaike S M van Mourik
  • Evelien A N Oostdijk
  • Rob J L Willems
  • Marc J M Bonten
  • Mark W J van Passel
  • Hauke Smidt
  • Willem van Schaik
  • Microbiome.2017 08;5(1):88. 10.1186/s40168-017-0309-z. doi: 10.1186/s40168-017-0309-z.Epub 2017-08-14.

肥大から不全への移行期における左室応答は、大動脈弁逆流症マウスにおけるAkt、β-アレスチン-2、CaMKIIの異なる役割を再現している

Left ventricular response in the transition from hypertrophy to failure recapitulates distinct roles of Akt, β-arrestin-2, and CaMKII in mice with aortic regurgitation.
  • Jian Wu
  • Jieyun You
  • Xiaoyan Wang
  • Shijun Wang
  • Jiayuan Huang
  • Qihai Xie
  • Baoyong Gong
  • Zhiwen Ding
  • Yong Ye
  • Cong Wang
  • Le Kang
  • Ran Xu
  • Yang Li
  • Ruizhen Chen
  • Aijun Sun
  • Xiangdong Yang
  • Hong Jiang
  • Fenghua Yang
  • Peter H Backx
  • Junbo Ge
  • Yunzeng Zou
  • Ann Transl Med.2020 Mar;8(5):219. atm-08-05-219. doi: 10.21037/atm.2020.01.51.

食事の全血DNAメチル化シグネチャーは、心血管疾患のリスク因子と全原因死亡率と関連している

Whole Blood DNA Methylation Signatures of Diet Are Associated with Cardiovascular Disease Risk Factors and All-cause Mortality.
  • Jiantao Ma
  • Casey M Rebholz
  • Kim V E Braun
  • Lindsay M Reynolds
  • Stella Aslibekyan
  • Rui Xia
  • Niranjan G Biligowda
  • Tianxiao Huan
  • Chunyu Liu
  • Michael M Mendelson
  • Roby Joehanes
  • Emily A Hu
  • Mara Z Vitolins
  • Alexis C Wood
  • Kurt Lohman
  • Carolina Ochoa-Rosales
  • Joyce van Meurs
  • André Uitterlinden
  • Yongmei Liu
  • Mohamed A Elhadad
  • Margit Heier
  • Melanie Waldenberger
  • Annette Peters
  • Elena Colicino
  • Eric A Whitsel
  • Antoine Baldassari
  • Sina A Gharib
  • Nona Sotoodehnia
  • Jennifer A Brody
  • Colleen M Sitlani
  • Toshiko Tanaka
  • W David Hill
  • Janie Corley
  • Ian J Deary
  • Yan Zhang
  • Ben Schöttker
  • Hermann Brenner
  • Maura E Walker
  • Shumao Ye
  • Steve Nguyen
  • Jim Pankow
  • Ellen W Demerath
  • Yinan Zheng
  • Lifang Hou
  • Liming Liang
  • Alice H Lichtenstein
  • Frank B Hu
  • Myriam Fornage
  • Trudy Voortman
  • Daniel Levy
  • Circ Genom Precis Med.2020 Jun;doi: 10.1161/CIRCGEN.119.002766.Epub 2020-06-11.

Sm遺伝子のゲノムワイドな同定と発現解析により、Dimocarpus longan Lourの初期体性胚発生に関与していることが明らかになった

Genome-wide identification and expression analyses of Sm genes reveal their involvement in early somatic embryogenesis in Dimocarpus longan Lour.
  • Xue Li
  • Yan Chen
  • Shuting Zhang
  • Liyao Su
  • Xiaoping Xu
  • Xiaohui Chen
  • Zhongxiong Lai
  • Yuling Lin
  • PLoS ONE.2020;15(4):e0230795. PONE-D-20-00319. doi: 10.1371/journal.pone.0230795.Epub 2020-04-03.

Bialowieza原始原生林のバイソンにおける肝臓フルークのミトコンドリアDNAハプロタイプ解析により、家畜が感染源である可能性が示唆された

Mitochondrial DNA haplotype analysis of liver fluke in bison from Bialowieza Primaeval Forest indicates domestic cattle as the likely source of infection.
  • Stephen M Walker
  • Aleksander W Demiaszkiewicz
  • Monika Kozak
  • Halina Wedrychowicz
  • Denitsa Teofanova
  • Paulo Prodohl
  • Gerry Brennan
  • Ian Fairweather
  • Elizabeth M Hoey
  • Alan Trudgett
  • Vet. Parasitol..2013 Jan;191(1-2):161-4. S0304-4017(12)00415-3. doi: 10.1016/j.vetpar.2012.08.002.Epub 2012-08-09.

アンドロゲンは、思春期の雄ラットのCA1海馬下野の錐体神経細胞の内在性可塑性のダイナミクスに影響を与える

Androgen Affects the Dynamics of Intrinsic Plasticity of Pyramidal Neurons in the CA1 Hippocampal Subfield in Adolescent Male Rats.
  • Md Nabiul Islam
  • Yuya Sakimoto
  • Mir Rubayet Jahan
  • Mako Ishida
  • Abu Md Mamun Tarif
  • Kanako Nozaki
  • Koh-Hei Masumoto
  • Akie Yanai
  • Dai Mitsushima
  • Koh Shinoda
  • Neuroscience.2020 Aug;440:15-29. S0306-4522(20)30319-5. doi: 10.1016/j.neuroscience.2020.05.025.Epub 2020-05-23.

子豚(離乳)、肥育用鶏、産卵用に飼育された鶏、肥育用七面鳥、繁殖用に飼育された七面鳥の飼料添加物としての ECONASEXT (endo-1,4-β-キシラナーゼ) の認可更新申請の評価

Assessment of the application for renewal of authorisation of ECONASEXT (endo-1,4-β-xylanase) as a feed additive for piglets (weaned), chickens for fattening, chickens reared for laying, turkeys for fattening and turkeys reared for breeding.
  • Vasileios Bampidis
  • Giovanna Azimonti
  • Maria de Lourdes Bastos
  • Henrik Christensen
  • Birgit Dusemund
  • Maryline Kouba
  • Mojca Kos Durjava
  • Marta López-Alonso
  • Secundino López Puente
  • Francesca Marcon
  • Baltasar Mayo
  • Alena Pechová
  • Mariana Petkova
  • Fernando Ramos
  • Yolanda Sanz
  • Roberto Villa
  • Ruud Woutersen
  • Pier Sandro Cocconcelli
  • Boet Glandorf
  • Lieve Herman
  • Miguel Maradona Prieto
  • Maria Saarela
  • Jaume Galobart
  • Lucilla Gregoretti
  • Matteo Lorenzo Innocenti
  • Gloria López Gálvez
  • Konstantinos Sofianidis
  • Maria Vittoria Vettori
  • Rosella Brozzi
  • EFSA J.2019 Nov;17(11):e05880. EFS25880. doi: 10.2903/j.efsa.2019.5880.Epub 2019-11-07.

茶ポリフェノールは、海馬ニューロンにおけるBDNF-TrkB/AktおよびErk1/2シグナル伝達軸を調節することにより、スタウロスポリン誘発細胞毒性およびアポトーシスを減衰させる

Tea polyphenols attenuate staurosporine-induced cytotoxicity and apoptosis by modulating BDNF-TrkB/Akt and Erk1/2 signaling axis in hippocampal neurons.
  • Jian-Rong Yang
  • Teng-Teng Ren
  • Rongfeng Lan
  • Xiao-Yan Qin
  • IBRO Rep.2020 Jun;8:115-121. S2451-8301(20)30012-1. doi: 10.1016/j.ibror.2020.04.002.Epub 2020-04-19.

機械学習と知識工学を用いた電子カルテにおける希少疾患の検出急性肝ポルフィリン症のケーススタディ

Detecting rare diseases in electronic health records using machine learning and knowledge engineering: Case study of acute hepatic porphyria.
  • Aaron M Cohen
  • Steven Chamberlin
  • Thomas Deloughery
  • Michelle Nguyen
  • Steven Bedrick
  • Stephen Meninger
  • John J Ko
  • Jigar J Amin
  • Alex J Wei
  • William Hersh
  • PLoS ONE.2020;15(7):e0235574. PONE-D-20-10338. doi: 10.1371/journal.pone.0235574.Epub 2020-07-02.

急性心筋梗塞を有するブタの再灌流に先立って同種心筋細胞の冠動脈内投与は、梗塞サイズを減少させ、心臓リモデリングの悪化を抑制する

Intracoronary Administration of Allogeneic Cardiosphere-Derived Cells Immediately Prior to Reperfusion in Pigs With Acute Myocardial Infarction Reduces Infarct Size and Attenuates Adverse Cardiac Remodeling.
  • Vasileios Sousonis
  • Titika Sfakianaki
  • Argirios Ntalianis
  • Ioannis Nanas
  • Christos Kontogiannis
  • Dionysios Aravantinos
  • Chris Kapelios
  • Lampros Katsaros
  • Maria Nana
  • Dimitrios Sampaziotis
  • Despina Sanoudou
  • Apostolos Papalois
  • Konstantinos Malliaras
  • J. Cardiovasc. Pharmacol. Ther..2020 Jul;:1074248420941672. doi: 10.1177/1074248420941672.Epub 2020-07-17.

X線結晶学、IR/Raman分光学、周期的DFTを組み合わせた新規多成分制吐剤結晶形態の研究。マレイン酸カルベンダジムを例にして

Combined X-ray Crystallographic, IR/Raman Spectroscopic, and Periodic DFT Investigations of New Multicomponent Crystalline Forms of Anthelmintic Drugs: A Case Study of Carbendazim Maleate.
  • Alexander P Voronin
  • Artem O Surov
  • Andrei V Churakov
  • Olga D Parashchuk
  • Alexey A Rykounov
  • Mikhail V Vener
  • Molecules.2020 May;25(10). E2386. doi: 10.3390/molecules25102386.Epub 2020-05-21.

発作性夜行性ヘモグロビン尿症:プレドニゾンにするか、プレドニゾンにしないか--以前に15年間ステロイドで治療された患者の症例報告とエクリズマブでの有意な反応

Paroxysmal nocturnal haemoglobinuria: to prednisone or not to prednisone?--a case report of a patient previously treated with steroids for 15 yrs and significant response on eculizumab.
  • Alexander Röth
  • Ferras Alashkar
  • Dörte Herich-Terhürne
  • Ulrich Dührsen
  • Eur. J. Haematol..2015 Aug;95(2):177-80. doi: 10.1111/ejh.12480.Epub 2015-03-29.

局所的な冠動脈狭窄を有する豚モデルの経皮的作製には、3Dプリント冠動脈インプラントが有効である

3D-Printed Coronary Implants Are Effective for Percutaneous Creation of Swine Models with Focal Coronary Stenosis.
  • Caroline M Colbert
  • Jiaxin Shao
  • John J Hollowed
  • Jesse W Currier
  • Olujimi A Ajijola
  • Gregory A Fishbein
  • Sandra M Duarte-Vogel
  • Rohan Dharmakumar
  • Peng Hu
  • Kim-Lien Nguyen
  • J Cardiovasc Transl Res.2020 May;10.1007/s12265-020-10018-3. doi: 10.1007/s12265-020-10018-3.Epub 2020-05-11.