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日本語AIでPubMedを検索

日本語AIでPubMedを検索

PubMedの提供する医学論文データベースを日本語で検索できます。AI(Deep Learning)を活用した機械翻訳エンジンにより、精度高く日本語へ翻訳された論文をご参照いただけます。

みんなが読んでいる論文

機能評価は日常の視覚機能を予測するか?軽・中等度加齢黄斑変性症における視覚機能検査とQOL

Does functional assessment predict everyday visual functioning? Visual function testing and quality of life in mild/moderate age-related macular degeneration.
  • Geoffrey K Broadhead
  • Thomas Hong
  • John R Grigg
  • Peter McCluskey
  • Timothy E Schlub
  • Kimberly Spooner
  • Andrew A Chang
  • Int Ophthalmol.2020 Jul;10.1007/s10792-020-01508-z. doi: 10.1007/s10792-020-01508-z.Epub 2020-07-14.

乳酸菌を代替抗生物質増殖促進剤として与えることにより、ニホンウズラ()の卵外・内卵の品質が改善された

Improves in external and internal egg quality of Japanese quail () by giving lactic acid bacteria as alternative antibiotic growth promoter.
  • Widya Paramita Lokapirnasari
  • Anam Al Arif
  • Soeharsono Soeharsono
  • Anisah Fathinah
  • Rifqi Najwan
  • Hana Cipka Pramuda Wardhani
  • Nabil Fariz Noorrahman
  • Khoirul Huda
  • Nuria Ulfah
  • Andreas Berny Yulianto
  • Iran J Microbiol.2019 Oct;11(5):406-411.

フィンランドで全国的に組織されたヘリコプター救急医療サービスの最初の7年間 - 質の高い登録簿からのデータ

The first seven years of nationally organized helicopter emergency medical services in Finland - the data from quality registry.
  • Anssi Saviluoto
  • Johannes Björkman
  • Anna Olkinuora
  • Ilkka Virkkunen
  • Hetti Kirves
  • Piritta Setälä
  • Ilkka Pulkkinen
  • Päivi Laukkanen-Nevala
  • Lasse Raatiniemi
  • Helena Jäntti
  • Timo Iirola
  • Jouni Nurmi
  • Scand J Trauma Resusc Emerg Med.2020 May;28(1):46. 10.1186/s13049-020-00739-4. doi: 10.1186/s13049-020-00739-4.Epub 2020-05-29.

標的媒介薬物動態モデルのMichaelis-Menten近似を用いた健康なボランティアまたは高コレステロール血症患者におけるアリロクマブの母集団薬物動態解析-生物学的製剤ライセンス申請支援-.第1部

Population Pharmacokinetic Analysis of Alirocumab in Healthy Volunteers or Hypercholesterolemic Subjects Using a Michaelis-Menten Approximation of a Target-Mediated Drug Disposition Model-Support for a Biologics License Application Submission: Part I.
  • Jean-Marie Martinez
  • Aurélie Brunet
  • Fabrice Hurbin
  • A Thomas DiCioccio
  • Clémence Rauch
  • David Fabre
  • Clin Pharmacokinet.2019 01;58(1):101-113. 10.1007/s40262-018-0669-y. doi: 10.1007/s40262-018-0669-y.

光化学系II阻害剤としてのインドール窒素ハイブリッドの合理的設計・合成・評価

Rational Design, Synthesis and Evaluation of Indole Nitrogen Hybrids as Photosystem II Inhibitors.
  • Jéssica Maria de Souza
  • Bruno Rodrigues Fazolo
  • Jhully Wellen Ferreira Lacerda
  • Mariana de Souza Moura
  • Arielly Celestino Rodrigues Dos Santos
  • Leonardo Gomes de Vasconcelos
  • Paulo Teixeira de Sousa Junior
  • Evandro Luiz Dall'Oglio
  • Akbar Ali
  • Olívia Moreira Sampaio
  • Lucas Campos Curcino Vieira
  • Photochem. Photobiol..2020 Jun;doi: 10.1111/php.13295.Epub 2020-06-13.

2種のグリプチンとその主な合成不純物のin vitro毒性評価

In vitro toxic evaluation of two gliptins and their main impurities of synthesis.
  • Camila F A Giordani
  • Sarah Campanharo
  • Nathalie R Wingert
  • Lívia M Bueno
  • Joanna W Manoel
  • Barbara Costa
  • Shanda Cattani
  • Marcelo Dutra Arbo
  • Solange Cristina Garcia
  • Cássia Virginia Garcia
  • Nádia Maria Volpato
  • Elfrides Eva Scherman Schapoval
  • Martin Steppe
  • BMC Pharmacol Toxicol.2019 12;20(Suppl 1):82. 10.1186/s40360-019-0354-2. doi: 10.1186/s40360-019-0354-2.Epub 2019-12-19.

結核治療レジメンへの高用量イソニアジドの組み入れをガイドするためのイソニアジド耐性マーカーの同定:システマティックレビュー

Identifying isoniazid resistance markers to guide inclusion of high-dose isoniazid in tuberculosis treatment regimens: a systematic review.
  • Emmanuel Rivière
  • Michael G Whitfield
  • Jochem Nelen
  • Tim H Heupink
  • Annelies Van Rie
  • Clin. Microbiol. Infect..2020 Jul;S1198-743X(20)30387-6. doi: 10.1016/j.cmi.2020.07.004.Epub 2020-07-09.

機械学習とマルチパラメトリック脳MRIによる多発性硬化症とスフェロイドを伴う遺伝性びまん性白血病の鑑別

Machine Learning and Multiparametric Brain MRI to Differentiate Hereditary Diffuse Leukodystrophy with Spheroids from Multiple Sclerosis.
  • Gabriel Mangeat
  • Russell Ouellette
  • Maxime Wabartha
  • Benjamin De Leener
  • Michael Plattén
  • Virginija Danylaité Karrenbauer
  • Marcel Warntjes
  • Nikola Stikov
  • Caterina Mainero
  • Julien Cohen-Adad
  • Tobias Granberg
  • J Neuroimaging.2020 May;doi: 10.1111/jon.12725.Epub 2020-05-26.

フィブリノーゲンγ鎖ペプチド被覆、ADP カプセル化リポソームの心肺バイパス凝固症後の止血アジュバントとしての治療的可能性

Therapeutic potential of fibrinogen γ-chain peptide-coated, ADP-encapsulated liposomes as a haemostatic adjuvant for post-cardiopulmonary bypass coagulopathy.
  • Osamu Ishida
  • Kohsuke Hagisawa
  • Nozomu Yamanaka
  • Koji Tsutsumi
  • Hidenori Suzuki
  • Masato Takikawa
  • Shinji Takeoka
  • Manabu Kinoshita
  • Sci Rep.2020 Jul;10(1):11308. 10.1038/s41598-020-68307-5. doi: 10.1038/s41598-020-68307-5.Epub 2020-07-09.

フォークヘッドボックス(FOX)G1は、T-cell factor-4/β-カテニン/FOXG1複合体を形成し、Wntシグナルを活性化することで、肝細胞癌の上皮-間葉系転移を促進する

Forkhead box (FOX) G1 promotes hepatocellular carcinoma epithelial-Mesenchymal transition by activating Wnt signal through forming T-cell factor-4/Beta-catenin/FOXG1 complex.
  • Xingrong Zheng
  • Jiaxin Lin
  • Hewei Wu
  • Zhishuo Mo
  • Yunwen Lian
  • Peipei Wang
  • Zhaoxia Hu
  • Zhiliang Gao
  • Liang Peng
  • Chan Xie
  • J. Exp. Clin. Cancer Res..2019 Nov;38(1):475. 10.1186/s13046-019-1433-3. doi: 10.1186/s13046-019-1433-3.Epub 2019-11-27.

症候性脳転移を再発した患者における救済療法としてのベバシズマブをベースとした治療

Bevacizumab-based treatment as salvage therapy in patients with recurrent symptomatic brain metastases.
  • Anna Sophie Berghoff
  • Michael Oliver Breckwoldt
  • Lars Riedemann
  • Kianush Karimian-Jazi
  • Sarah Loew
  • Franziska Schlieter
  • Julia Furtner
  • Marc Cinci
  • Michael Thomas
  • Moritz J Strowitzki
  • Frederik Marmé
  • Laura L Michel
  • Thomas Schmidt
  • Dirk Jäger
  • Martin Bendszus
  • Matthias Preusser
  • Wolfgang Wick
  • Frank Winkler
  • Neurooncol Adv.2020 Jan-Dec;2(1):vdaa038. vdaa038. doi: 10.1093/noajnl/vdaa038.Epub 2020-03-16.

慢性疼痛を持つ児童・青少年に対するデジタルヘルス心理学的介入(WebMAP Mobile):ハイブリッド有効性実施段階的ウェッジクラスター無作為化試験の結果

A digital health psychological intervention (WebMAP Mobile) for children and adolescents with chronic pain: results of a hybrid effectiveness-implementation stepped wedge cluster randomized trial.
  • Tonya M Palermo
  • Rocio de la Vega
  • Caitlin Murray
  • Emily Law
  • Chuan Zhou
  • Pain.2020 Jul;doi: 10.1097/j.pain.0000000000001994.Epub 2020-07-10.

新血管性加齢黄斑変性症におけるQoLに関して、ベバシズマブの6週および8週の注射頻度は、現在の4週の注射頻度よりも非劣性である:無作為化比較試験

Six and eight weeks injection frequencies of bevacizumab are non-inferior to the current four weeks injection frequency for quality of life in neovascular age-related macular degeneration: a randomized controlled trial.
  • Martijn S Visser
  • Sankha Amarakoon
  • Tom Missotten
  • Reinier Timman
  • Jan J V Busschbach
  • Qual Life Res.2020 Jul;10.1007/s11136-020-02580-9. doi: 10.1007/s11136-020-02580-9.Epub 2020-07-14.

アレルギー性鼻炎治療における間接灸の有効性と安全性.RCT のシステマティックレビューとメタアナリシスのためのプロトコル

Effectiveness and safety of indirect moxibustion for the treatment of allergic rhinitis: A protocol for systematic review and meta-analysis of RCTs.
  • Ting Yuan
  • Yong Fu
  • Jun Xiong
  • Haifeng Zhang
  • Jun Yang
  • Xue Wang
  • Hao Fan
  • Yunfeng Jiang
  • Xiaohong Zhou
  • Kai Liao
  • Lingling Xu
  • Medicine (Baltimore).2020 Jul;99(28):e20911. 00005792-202007100-00036. doi: 10.1097/MD.0000000000020911.

脊髄筋萎縮におけるヒト骨格筋線維におけるIバンドおよびMバンドからのSMNの誤局在化は、サルコメアの一次構造変化と関連している

Mislocalization of SMN from the I-band and M-band in human skeletal myofibers in spinal muscular atrophy associates with primary structural alterations of the sarcomere.
  • María T Berciano
  • María S Castillo-Iglesias
  • J Fernando Val-Bernal
  • Vanesa Lafarga
  • José C Rodriguez-Rey
  • Miguel Lafarga
  • Olga Tapia
  • Cell Tissue Res..2020 Jul;10.1007/s00441-020-03236-3. doi: 10.1007/s00441-020-03236-3.Epub 2020-07-16.

遺伝的変異は、血漿アンジオポエチン-2が急性腎障害のサブタイプの発生に関与していることを示唆している

Genetic variation implicates plasma angiopoietin-2 in the development of acute kidney injury sub-phenotypes.
  • Pavan K Bhatraju
  • Max Cohen
  • Ryan J Nagao
  • Eric D Morrell
  • Susanna Kosamo
  • Xin-Ya Chai
  • Robin Nance
  • Victoria Dmyterko
  • Joseph Delaney
  • Jason D Christie
  • Kathleen D Liu
  • Carmen Mikacenic
  • Sina A Gharib
  • W Conrad Liles
  • Ying Zheng
  • David C Christiani
  • Jonathan Himmelfarb
  • Mark M Wurfel
  • BMC Nephrol.2020 Jul;21(1):284. 10.1186/s12882-020-01935-1. doi: 10.1186/s12882-020-01935-1.Epub 2020-07-17.

原発性副甲状腺機能亢進症の骨粗鬆症患者におけるカルシウム、腎、および骨への影響に関する副甲状腺摘出術と比較したデノスマブの効果

Effects of denosumab as compared with parathyroidectomy regarding calcium, renal, and bone involvement in osteoporotic patients with primary hyperparathyroidism.
  • Daichi Miyaoka
  • Yasuo Imanishi
  • Eiko Kato
  • Norikazu Toi
  • Yuki Nagata
  • Masafumi Kurajoh
  • Shinsuke Yamada
  • Masaaki Inaba
  • Masanori Emoto
  • Endocrine.2020 Jul;10.1007/s12020-020-02401-6. doi: 10.1007/s12020-020-02401-6.Epub 2020-07-03.

危機的状況の中で必要な枠組みとしての障害者の権利 標準ケアと今後の医療のあり方

Disability Rights as a Necessary Framework for Crisis Standards of Care and the Future of Health Care.
  • Laura Guidry-Grimes
  • Katie Savin
  • Joseph A Stramondo
  • Joel Michael Reynolds
  • Marina Tsaplina
  • Teresa Blankmeyer Burke
  • Angela Ballantyne
  • Eva Feder Kittay
  • Devan Stahl
  • Jackie Leach Scully
  • Rosemarie Garland-Thomson
  • Anita Tarzian
  • Doron Dorfman
  • Joseph J Fins
  • Hastings Cent Rep.2020 May;50(3):28-32. doi: 10.1002/hast.1128.

培養哺乳類細胞において、Gタンパク質共役型受容体55アゴニストであるリゾホスファチジルイノシトールを生理活性モノアシルグリセロールに変換するエクト型ホスホリパーゼCとしてのヒトグリセロホスホジエステラーゼ3の同定

Identification of human glycerophosphodiesterase 3 as an ecto phospholipase C that converts the G protein-coupled receptor 55 agonist lysophosphatidylinositol to bioactive monoacylglycerols in cultured mammalian cells.
  • Toshihiko Tsutsumi
  • Risa Matsuda
  • Katsuya Morito
  • Kohei Kawabata
  • Miho Yokota
  • Miki Nikawadori
  • Manami Inoue-Fujiwara
  • Satoshi Kawashima
  • Mayumi Hidaka
  • Takenori Yamamoto
  • Naoshi Yamazaki
  • Tamotsu Tanaka
  • Yasuo Shinohara
  • Hiroyuki Nishi
  • Akira Tokumura
  • Biochim Biophys Acta Mol Cell Biol Lipids.2020 Jul;1865(9):158761. S1388-1981(20)30153-0. doi: 10.1016/j.bbalip.2020.158761.Epub 2020-07-03.

ミトコンドリア機能障害と高カルシウム負荷の組み合わせは、黒質ドーパミン作動性ニューロンの選択的喪失の背景にある抗酸化防御機能の低下をもたらします

Mitochondrial Dysfunction Combined with High Calcium Load Leads to Impaired Antioxidant Defense Underlying the Selective Loss of Nigral Dopaminergic Neurons.
  • Konrad M Ricke
  • Thomas Paß
  • Sammy Kimoloi
  • Kai Fährmann
  • Christian Jüngst
  • Astrid Schauss
  • Olivier R Baris
  • Marijana Aradjanski
  • Aleksandra Trifunovic
  • Therese M Eriksson Faelker
  • Matteo Bergami
  • Rudolf J Wiesner
  • J. Neurosci..2020 Feb;40(9):1975-1986. JNEUROSCI.1345-19.2019. doi: 10.1523/JNEUROSCI.1345-19.2019.Epub 2020-01-31.

COVID-19ウイルス由来RNA依存性RNAポリメラーゼの構造

Structure of the RNA-dependent RNA polymerase from COVID-19 virus.
  • Yan Gao
  • Liming Yan
  • Yucen Huang
  • Fengjiang Liu
  • Yao Zhao
  • Lin Cao
  • Tao Wang
  • Qianqian Sun
  • Zhenhua Ming
  • Lianqi Zhang
  • Ji Ge
  • Litao Zheng
  • Ying Zhang
  • Haofeng Wang
  • Yan Zhu
  • Chen Zhu
  • Tianyu Hu
  • Tian Hua
  • Bing Zhang
  • Xiuna Yang
  • Jun Li
  • Haitao Yang
  • Zhijie Liu
  • Wenqing Xu
  • Luke W Guddat
  • Quan Wang
  • Zhiyong Lou
  • Zihe Rao
  • Science.2020 05;368(6492):779-782. science.abb7498. doi: 10.1126/science.abb7498.Epub 2020-04-10.

レビー小体型認知症のサブタイプは、α-シヌクレインとタウの分布に関連している

Subtypes of dementia with Lewy bodies are associated with α-synuclein and tau distribution.
  • Tanis J Ferman
  • Naoya Aoki
  • Bradley F Boeve
  • Jeremiah A Aakre
  • Kejal Kantarci
  • Jonathan Graff-Radford
  • Joseph E Parisi
  • Jay A Van Gerpen
  • Neill R Graff-Radford
  • Ryan J Uitti
  • Otto Pedraza
  • Melissa E Murray
  • Zbigniew K Wszolek
  • R Ross Reichard
  • Julie A Fields
  • Owen A Ross
  • David S Knopman
  • Ronald C Petersen
  • Dennis W Dickson
  • Neurology.2020 Jul;95(2):e155-e165. WNL.0000000000009763. doi: 10.1212/WNL.0000000000009763.Epub 2020-06-19.

細菌ベンゾイルコエンザイムAリガーゼと植物III型ポリケチド合成酵素に由来する生理活性分子の化学酵素合成と生物学的評価

Chemoenzymatic Synthesis and Biological Evaluation for Bioactive Molecules Derived from Bacterial Benzoyl Coenzyme A Ligase and Plant Type III Polyketide Synthase.
  • Kamal Adhikari
  • I-Wen Lo
  • Chun-Liang Chen
  • Yung-Lin Wang
  • Kuan-Hung Lin
  • Saeid Malek Zadeh
  • Rajesh Rattinam
  • Yi-Shan Li
  • Chang-Jer Wu
  • Tsung-Lin Li
  • Biomolecules.2020 May;10(5). E738. doi: 10.3390/biom10050738.Epub 2020-05-09.

ストライプドキャットフィッシュ(Pangasianodon hypophthalmus)の頭部腎臓白血球に対するPhyllanthus amarusとPsidium guajavaの抽出物、画分および純粋な化合物の免疫調節能

Immunomodulatory potential of extracts, fractions and pure compounds from Phyllanthus amarus and Psidium guajava on striped catfish (Pangasianodon hypophthalmus) head kidney leukocytes.
  • Truong Quynh Nhu
  • Nguyen Phuc Dam
  • Bui Thi Bich Hang
  • Le Thi Bach
  • Do Thi Thanh Huong
  • Bui Thi Buu Hue
  • Marie-Louise Scippo
  • Nguyen Thanh Phuong
  • Joëlle Quetin-Leclercq
  • Patrick Kestemont
  • Fish Shellfish Immunol..2020 Jun;104:289-303. S1050-4648(20)30378-8. doi: 10.1016/j.fsi.2020.05.051.Epub 2020-06-13.

人間の採食の生活史。異文化と個体間の変動

The life history of human foraging: Cross-cultural and individual variation.
  • Jeremy Koster
  • Richard McElreath
  • Kim Hill
  • Douglas Yu
  • Glenn Shepard
  • Nathalie van Vliet
  • Michael Gurven
  • Benjamin Trumble
  • Rebecca Bliege Bird
  • Douglas Bird
  • Brian Codding
  • Lauren Coad
  • Luis Pacheco-Cobos
  • Bruce Winterhalder
  • Karen Lupo
  • Dave Schmitt
  • Paul Sillitoe
  • Margaret Franzen
  • Michael Alvard
  • Vivek Venkataraman
  • Thomas Kraft
  • Kirk Endicott
  • Stephen Beckerman
  • Stuart A Marks
  • Thomas Headland
  • Margaretha Pangau-Adam
  • Anders Siren
  • Karen Kramer
  • Russell Greaves
  • Victoria Reyes-García
  • Maximilien Guèze
  • Romain Duda
  • Álvaro Fernández-Llamazares
  • Sandrine Gallois
  • Lucentezza Napitupulu
  • Roy Ellen
  • John Ziker
  • Martin R Nielsen
  • Elspeth Ready
  • Christopher Healey
  • Cody Ross
  • Sci Adv.2020 Jun;6(26):eaax9070. aax9070. doi: 10.1126/sciadv.aax9070.Epub 2020-06-24.