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日本語AIでPubMedを検索

日本語AIでPubMedを検索

PubMedの提供する医学論文データベースを日本語で検索できます。AI(Deep Learning)を活用した機械翻訳エンジンにより、精度高く日本語へ翻訳された論文をご参照いただけます。

みんなが読んでいる論文

ピンナップ類における生態進化のスケールを超えた遺伝的変動の決定要因

Determinants of genetic variation across eco-evolutionary scales in pinnipeds.
  • Claire R Peart
  • Sergio Tusso
  • Saurabh D Pophaly
  • Fidel Botero-Castro
  • Chi-Chih Wu
  • David Aurioles-Gamboa
  • Amy B Baird
  • John W Bickham
  • Jaume Forcada
  • Filippo Galimberti
  • Neil J Gemmell
  • Joseph I Hoffman
  • Kit M Kovacs
  • Mervi Kunnasranta
  • Christian Lydersen
  • Tommi Nyman
  • Larissa Rosa de Oliveira
  • Anthony J Orr
  • Simona Sanvito
  • Mia Valtonen
  • Aaron B A Shafer
  • Jochen B W Wolf
  • Nat Ecol Evol.2020 Jun;10.1038/s41559-020-1215-5. doi: 10.1038/s41559-020-1215-5.Epub 2020-06-08.

脂肪率の上昇に伴う多嚢胞性卵巣症候群は、レプチンやアディポネクチンとは異なるTNF-αおよびIL-6の血清レベルを阻害する

Polycystic ovary syndrome associated with increased adiposity interferes with serum levels of TNF-alpha and IL-6 differently from leptin and adiponectin.
  • Nathália Sigilló Cardoso
  • Victor Barbosa Ribeiro
  • Sabrina Graziani Veloso Dutra
  • Rui Alberto Ferriani
  • Ada Clarice Gastaldi
  • João Eduardo de Araújo
  • Hugo Celso Dutra de Souza
  • Arch Endocrinol Metab.2020 Feb;64(1):4-10. S2359-39972020000100004. doi: 10.20945/2359-3997000000197.Epub 2020-03-13.

ヤギから採取したネコノミ(Ctenocephalides felis)サンプルのパラ遺伝子におけるノックダウン耐性変異の高頻度

High frequency of knockdown resistance mutations in the para gene of cat flea (Ctenocephalides felis) samples collected from goats.
  • Sedef Erkunt Alak
  • Ahmet Efe Köseoğlu
  • Çağrı Kandemir
  • Turğay Taşkın
  • Samiye Demir
  • Mert Döşkaya
  • Cemal Ün
  • Hüseyin Can
  • Parasitol. Res..2020 Jul;119(7):2067-2073. 10.1007/s00436-020-06714-3. doi: 10.1007/s00436-020-06714-3.Epub 2020-05-28.

ポリマーフリーと耐久性のあるポリマー薬剤溶出冠動脈ステントの無作為化試験からの10年間の成績

10-Year Outcomes From a Randomized Trial of Polymer-Free Versus Durable Polymer Drug-Eluting Coronary Stents.
  • Sebastian Kufner
  • Maximilian Ernst
  • Salvatore Cassese
  • Michael Joner
  • Katharina Mayer
  • Roisin Colleran
  • Tobias Koppara
  • Erion Xhepa
  • Tobias Koch
  • Jens Wiebe
  • Tareq Ibrahim
  • Massimiliano Fusaro
  • Karl-Ludwig Laugwitz
  • Heribert Schunkert
  • Adnan Kastrati
  • Robert A Byrne
  • J. Am. Coll. Cardiol..2020 Jul;76(2):146-158. S0735-1097(20)35314-6. doi: 10.1016/j.jacc.2020.05.026.

ボリビアの若い女性の間で効果的な避妊の受け入れと使用を増やすために携帯電話のインスタントメッセージングによって配信された介入。無作為化対照試験

An Intervention Delivered by Mobile Phone Instant Messaging to Increase Acceptability and Use of Effective Contraception Among Young Women in Bolivia: Randomized Controlled Trial.
  • Ona L McCarthy
  • Carolina Aliaga
  • Maria Eugenia Torrico Palacios
  • Jhonny López Gallardo
  • Silvia Huaynoca
  • Baptiste Leurent
  • Phil Edwards
  • Melissa Palmer
  • Irrfan Ahamed
  • Caroline Free
  • J. Med. Internet Res..2020 Jun;22(6):e14073. v22i6e14073. doi: 10.2196/14073.Epub 2020-06-22.

ステロイドのLC/ESI-MS/MSアッセイにおけるスループット向上のための複数の類似試薬を用いた誘導体化によるサンプルの多重化。血漿17α-ヒドロキシプロゲステロンを例に挙げています

Sample-multiplexing by derivatization using multiple analogous reagents for enhancing throughput in LC/ESI-MS/MS assay of steroids: Plasma 17α-hydroxyprogesterone as an example.
  • Miki Kamemura
  • Mai Yokota
  • Shoujiro Ogawa
  • Takahiro Sugiura
  • Tatsuya Higashi
  • J. Chromatogr. B Analyt. Technol. Biomed. Life Sci..2020 Jun;1146:122117. S1570-0232(20)30272-5. doi: 10.1016/j.jchromb.2020.122117.Epub 2020-04-15.

リソソームシアル酸トランスポーターSialinの新しいリガンドとしての芳香族またはヘテロ芳香族置換基を有するアミノ酸

Amino Acids Bearing Aromatic or Heteroaromatic Substituents as a New Class of Ligands for the Lysosomal Sialic Acid Transporter Sialin.
  • Lilian Dubois
  • Nicolas Pietrancosta
  • Alexandre Cabaye
  • Isabelle Fanget
  • Cécile Debacker
  • Pierre-André Gilormini
  • Patrick M Dansette
  • Julien Dairou
  • Christophe Biot
  • Roseline Froissart
  • Anne Goupil-Lamy
  • Hugues-Olivier Bertrand
  • Francine C Acher
  • Isabelle McCort-Tranchepain
  • Bruno Gasnier
  • Christine Anne
  • J. Med. Chem..2020 Jul;doi: 10.1021/acs.jmedchem.9b02119.Epub 2020-07-15.

現代の創薬を支援するためにzileutonとその不純物に関するインシリコ治療と毒性学的プロファイリングと組み合わせた薬剤分析

Pharmaceutical analysis combined with in-silico therapeutic and toxicological profiling on zileuton and its impurities to assist in modern drug discovery.
  • Saurabh B Ganorkar
  • Yvan Vander Heyden
  • Atul A Shirkhedkar
  • Deepak K Lokwani
  • Dinesh M Dhumal
  • Preeti S Bobade
  • J Pharm Biomed Anal.2020 Feb;179:112982. S0731-7085(19)31948-X. doi: 10.1016/j.jpba.2019.112982.Epub 2019-11-15.

妊娠初期および妊娠中期における経口ブドウ糖負荷試験中の代謝物の変化。PEARLS無作為化、制御された生活習慣試験からの知見

Changes in Metabolites During an Oral Glucose Tolerance Test in Early and Mid-Pregnancy: Findings from the PEARLS Randomized, Controlled Lifestyle Trial.
  • Danielle E Haslam
  • Jun Li
  • Liming Liang
  • Marijulie Martinez
  • Cristina Palacios
  • Maria A Trak-Fellermeier
  • Paul W Franks
  • Kaumudi Joshipura
  • Shilpa N Bhupathiraju
  • Metabolites.2020 Jul;10(7). E284. doi: 10.3390/metabo10070284.Epub 2020-07-10.

大西洋中部地域の小さな流域における水生炭素のフラックスと資源量をより正確に定量化するために、河床における土砂の膨張過程をモデル化した

Modeling sediment diagenesis processes on riverbed to better quantify aquatic carbon fluxes and stocks in a small watershed of the Mid-Atlantic region.
  • Junyu Qi
  • Xuesong Zhang
  • Sangchul Lee
  • Yiping Wu
  • Glenn E Moglen
  • Gregory W McCarty
  • Carbon Balance Manag.2020 Jul;15(1):13. 10.1186/s13021-020-00148-1. doi: 10.1186/s13021-020-00148-1.Epub 2020-07-06.

内視鏡的超音波ガイド下細針吸引を用いた膵臓悪性腫瘍の診断における細胞学的製剤と組織学的製剤の比較

Comparison of cytological and histological preparations in the diagnosis of pancreatic malignancies using endoscopic ultrasound-guided fine needle aspiration.
  • Dong Kee Jang
  • Sang Hyub Lee
  • Jun Kyu Lee
  • Woo Hyun Paik
  • Kwang Hyun Chung
  • Ban Seok Lee
  • Jun Hyuk Son
  • Jae Woo Lee
  • Ji Kon Ryu
  • Yong-Tae Kim
  • Kyoung-Bun Lee
  • HBPD INT.2017 Aug;16(4):418-423. S1499-3872(17)60035-3. doi: 10.1016/S1499-3872(17)60035-3.

網膜色素上皮細胞におけるオステオポンチンの浸透圧および低酸素誘導。浸透圧と低酸素による網膜色素上皮細胞におけるオステオポンチンの誘導:プリンリン作動性受容体シグナルの関与

Osmotic and hypoxic induction of osteopontin in retinal pigment epithelial cells: Involvement of purinergic receptor signaling.
  • Margrit Hollborn
  • Ricarda Brück
  • Heidrun Kuhrt
  • Peter Wiedemann
  • Andreas Bringmann
  • Mol. Vis..2020;26:188-203. Epub 2020-03-08.

切除した非小細胞肺癌患者における腫瘍浸潤リンパ球(TIL)の予後予測値、およびそのPD-L1発現およびDNA修復タンパク質RAD51との関連

Prognostic value of tumor-infiltrating lymphocytes (TILs) and their association with PD-L1 expression and DNA repair protein RAD51 in patients with resected non-small cell lung carcinoma.
  • Mariam Gachechiladze
  • Josef Škarda
  • Daniela Skanderová
  • Ivo Überall
  • Vítězslav Kolek
  • Petra Smičkova
  • Petr Vojta
  • Jana Vbrková
  • Marián Hajdúch
  • Ilay Shani
  • Zdeněk Kolář
  • Rolf Stahel
  • Walter Weder
  • Undine Rulle
  • Alex Soltermann
  • Markus Joerger
  • Lung Cancer.2020 Jun;147:30-38. S0169-5002(20)30499-2. doi: 10.1016/j.lungcan.2020.06.025.Epub 2020-06-23.

透視検査を行わない緩和的食道ステント留置術の臨床的有効性と安全性:システマティックレビューとメタアナリシス

Clinical efficacy and safety of palliative esophageal stenting without fluoroscopy: a systematic review and meta-analysis.
  • Saurabh Chandan
  • Babu P Mohan
  • Shahab R Khan
  • Neil Bhogal
  • Andrew Canakis
  • Mohammad Bilal
  • Amaninder S Dhaliwal
  • Muhammad Aziz
  • Harmeet S Mashiana
  • Shailender Singh
  • Wade Lee-Smith
  • Suresh Ponnada
  • Ishfaq Bhat
  • Douglas Pleskow
  • Endosc Int Open.2020 Jul;8(7):E944-E952. doi: 10.1055/a-1164-6398.Epub 2020-06-16.

テロメアの萎縮と機能不全:ナイメーヘン壊死症候群におけるプロジェロイド表現型の潜在的な引き金となる

Telomere attrition and dysfunction: a potential trigger of the progeroid phenotype in nijmegen breakage syndrome.
  • Raneem Habib
  • Ryong Kim
  • Heidemarie Neitzel
  • Ilja Demuth
  • Krystyna Chrzanowska
  • Eva Seemanova
  • Renaldo Faber
  • Martin Digweed
  • Reinhard Voss
  • Kathrin Jäger
  • Karl Sperling
  • Michael Walter
  • Aging (Albany NY).2020 Jun;12(12):12342-12375. 103453. doi: 10.18632/aging.103453.Epub 2020-06-20.

レム睡眠行動障害のバリアント:多施設研究

variants in REM sleep behavior disorder: a multicenter study.
  • Lynne Krohn
  • Jennifer A Ruskey
  • Uladzislau Rudakou
  • Etienne Leveille
  • Farnaz Asayesh
  • Michele T M Hu
  • Isabelle Arnulf
  • Yves Dauvilliers
  • Birgit Högl
  • Ambra Stefani
  • Christelle Charley Monaca
  • Abril Beatriz
  • Giuseppe Plazzi
  • Elena Antelmi
  • Luigi Ferini-Strambi
  • Anna Heidbreder
  • Bradley F Boeve
  • Alberto J Espay
  • Valérie Cochen De Cock
  • Brit Mollenhauer
  • Friederike Sixel-Döring
  • Claudia Trenkwalder
  • Karel Sonka
  • David Kemlink
  • Michela Figorilli
  • Monica Puligheddu
  • Femke Dijkstra
  • Mineke Viaene
  • Wolfgang Oertel
  • Marco Toffoli
  • Gian Luigi Gigli
  • Mariarosaria Valente
  • Jean-François Gagnon
  • Alex Desautels
  • Jacques Y Montplaisir
  • Ronald B Postuma
  • Guy A Rouleau
  • Ziv Gan-Or
  • Neurology.2020 Jun;10.1212/WNL.0000000000010042. doi: 10.1212/WNL.0000000000010042.Epub 2020-06-26.

悪性閉塞の緩和を目的とした新たに設計されたアンカバード胆道ステント:前向き研究の結果

A newly designed uncovered biliary stent for palliation of malignant obstruction: results of a prospective study.
  • Christopher Lawrence
  • Jose Nieto
  • Willis G Parsons
  • André Roy
  • Nalini M Guda
  • Stephen E Steinberg
  • Muhammad K Hasan
  • Juan Carlos Bucobo
  • Satish Nagula
  • Nicholas D Dey
  • Jonathan M Buscaglia
  • BMC Gastroenterol.2020 Jun;20(1):184. 10.1186/s12876-020-01325-9. doi: 10.1186/s12876-020-01325-9.Epub 2020-06-10.

HPVワクチン接種。イタリアコルポスコピー・子宮頸管・膣病理学会(SICPCV)のポジションペーパー

HPV Vaccination: The Position Paper of the Italian Society of Colposcopy and Cervico-Vaginal Pathology (SICPCV).
  • Andrea Ciavattini
  • Luca Giannella
  • Rosa De Vincenzo
  • Jacopo Di Giuseppe
  • Maria Papiccio
  • Ankica Lukic
  • Giovanni Delli Carpini
  • Antonio Perino
  • Antonio Frega
  • Francesco Sopracordevole
  • Maggiorino Barbero
  • Murat Gultekin
  • Vaccines (Basel).2020 Jul;8(3). E354. doi: 10.3390/vaccines8030354.Epub 2020-07-02.

Zophobas atratus(Coleoptera: Tenebrionidae)の幼虫であるスーパーワームにおける低密度ポリエチレンとポリスチレンの生分解。広範囲と限定された範囲での脱重合

Biodegradation of low-density polyethylene and polystyrene in superworms, larvae of Zophobas atratus (Coleoptera: Tenebrionidae): Broad and limited extent depolymerization.
  • Bo-Yu Peng
  • Yiran Li
  • Rui Fan
  • Zhibin Chen
  • Jiabin Chen
  • Anja M Brandon
  • Craig S Criddle
  • Yalei Zhang
  • Wei-Min Wu
  • Environ. Pollut..2020 Jul;266(Pt 1):115206. S0269-7491(20)31299-9. doi: 10.1016/j.envpol.2020.115206.Epub 2020-07-10.

有望な薬剤候補としての2つの新しいクラスの融合アザイサイトシン含有コンジェナー。デザイン、合成、およびin vitro、ex vivo、in silico試験

Two novel classes of fused azaisocytosine-containing congeners as promising drug candidates: Design, synthesis as well as in vitro, ex vivo and in silico studies.
  • Małgorzata Sztanke
  • Jolanta Rzymowska
  • Małgorzata Janicka
  • Krzysztof Sztanke
  • Bioorg. Chem..2020 Jan;95:103480. S0045-2068(19)30556-5. doi: 10.1016/j.bioorg.2019.103480.Epub 2019-12-09.

実践におけるイノベーション。思春期の若者のための弁証法的行動療法:公共コミュニティのメンタルヘルス環境における16週間のプログラムの多施設実施と評価

Innovations in Practice: Dialectical behaviour therapy for adolescents: multisite implementation and evaluation of a 16-week programme in a public community mental health setting.
  • Daniel Flynn
  • Mary Kells
  • Mary Joyce
  • Paul Corcoran
  • Conall Gillespie
  • Catalina Suarez
  • Michaela Swales
  • Ella Arensman
  • Child Adolesc Ment Health.2019 Feb;24(1):76-83. doi: 10.1111/camh.12298.Epub 2018-09-17.

エナンチオピュアなスピロインドリン-3,5'-オキサゾリジン-2,2'-ジオンの合成のための触媒フリーの立体選択的なCOのフォーマル3+2-環化付加反応を水および環境下で開発した

Catalyst-Free Stereocontrolled Formal [3 + 2]-Cycloaddition of CO for the Synthesis of Enantiopure Spiro[indoline-3,5'-oxazolidine]-2,2'-diones under Aqueous and Ambient Conditions.
  • Saumen Hajra
  • Anurag Biswas
  • Org. Lett..2020 Jul;22(13):4990-4994. doi: 10.1021/acs.orglett.0c01526.Epub 2020-06-16.

コンパニオンアニマル用殺虫剤であるフララナーの、業界をリードする農業用殺虫剤と比較した、抵抗性および感受性のあるアブラバエの株に対する毒性

Toxicity of fluralaner, a companion animal insecticide, relative to industry-leading agricultural insecticides against resistant and susceptible strains of filth flies.
  • Edwin R Burgess
  • Christopher J Geden
  • Kimberly H Lohmeyer
  • B H King
  • Erika T Machtinger
  • Jeffrey G Scott
  • Sci Rep.2020 Jul;10(1):11166. 10.1038/s41598-020-68121-z. doi: 10.1038/s41598-020-68121-z.Epub 2020-07-07.

21-ヒドロキシラーゼ欠損症による非古典的先天性副腎肥大症の小児および青年における遺伝子型-フェノタイプ相関

Genotype-phenotype correlations in children and adolescents with nonclassical congenital adrenal hyperplasia due to 21-hydroxylase deficiency.
  • Helmuth-Günther Dörr
  • Nadja Schulze
  • Markus Bettendorf
  • Gerhard Binder
  • Walter Bonfig
  • Christian Denzer
  • Desiree Dunstheimer
  • Kirsten Salzgeber
  • Heinrich Schmidt
  • Karl Otfried Schwab
  • Egbert Voss
  • Martin Wabitsch
  • Joachim Wölfle
  • Mol Cell Pediatr.2020 Jul;7(1):8. 10.1186/s40348-020-00100-w. doi: 10.1186/s40348-020-00100-w.Epub 2020-07-09.

老化ニッチでのPiwiの減少は、Toll-GSK3シグナル伝達を介して生殖細胞幹細胞を排除する

Piwi reduction in the aged niche eliminates germline stem cells via Toll-GSK3 signaling.
  • Kun-Yang Lin
  • Wen-Der Wang
  • Chi-Hung Lin
  • Elham Rastegari
  • Yu-Han Su
  • Yu-Tzu Chang
  • Yung-Feng Liao
  • Yi-Chieh Chang
  • Haiwei Pi
  • Bo-Yi Yu
  • Shu-Hwa Chen
  • Chung-Yen Lin
  • Mei-Yeh Lu
  • Tsu-Yi Su
  • Fei-Yang Tzou
  • Chih-Chiang Chan
  • Hwei-Jan Hsu
  • Nat Commun.2020 Jun;11(1):3147. 10.1038/s41467-020-16858-6. doi: 10.1038/s41467-020-16858-6.Epub 2020-06-19.

SEPN1関連ミオパチーにおける小胞体とミトコンドリアの接触不良と生体エネルギー

Defective endoplasmic reticulum-mitochondria contacts and bioenergetics in SEPN1-related myopathy.
  • Anne Filipe
  • Alexander Chernorudskiy
  • Sandrine Arbogast
  • Ersilia Varone
  • Rocío-Nur Villar-Quiles
  • Diego Pozzer
  • Maryline Moulin
  • Stefano Fumagalli
  • Eva Cabet
  • Swati Dudhal
  • Maria-Grazia De Simoni
  • Raphaël Denis
  • Nathalie Vadrot
  • Corinne Dill
  • Matteo Giovarelli
  • Luke Szweda
  • Clara De Palma
  • Paolo Pinton
  • Carlotta Giorgi
  • Carlo Viscomi
  • Emilio Clementi
  • Sonia Missiroli
  • Simona Boncompagni
  • Ester Zito
  • Ana Ferreiro
  • Cell Death Differ..2020 Jul;10.1038/s41418-020-0587-z. doi: 10.1038/s41418-020-0587-z.Epub 2020-07-13.

定量的グローバル研究により、真菌王国全体での開始コドンコンテキストによる翻訳制御の違いが明らかになった

Quantitative global studies reveal differential translational control by start codon context across the fungal kingdom.
  • Edward W J Wallace
  • Corinne Maufrais
  • Jade Sales-Lee
  • Laura R Tuck
  • Luciana de Oliveira
  • Frank Feuerbach
  • Frédérique Moyrand
  • Prashanthi Natarajan
  • Hiten D Madhani
  • Guilhem Janbon
  • Nucleic Acids Res..2020 03;48(5):2312-2331. 5724440. doi: 10.1093/nar/gkaa060.

ホエイプロテインは、組織特異的な方法で重要な抗酸化酵素の活性を高めることで、ラットの抗酸化プロファイルを向上させます

Whey protein boosts the antioxidant profile of rats by enhancing the activities of crucial antioxidant enzymes in a tissue-specific manner.
  • Aristidis S Veskoukis
  • Efthalia Kerasioti
  • Zoi Skaperda
  • Porfirios Apostolos Papapostolou
  • Charitini Nepka
  • Demetrios A Spandidos
  • Eftihia Asprodini
  • Ioannis Taitzoglou
  • Demetrios Kouretas
  • Food Chem. Toxicol..2020 Aug;142:111508. S0278-6915(20)30398-7. doi: 10.1016/j.fct.2020.111508.Epub 2020-06-13.

妊娠中のシトルリンやアルギニンと母親のサプリメントは、子宮内成長制限(IUGR)のモデルで胎児のアミノ酸の可用性に影響を与えます

Maternal supplementation with citrulline or arginine during gestation impacts fetal amino acid availability in a model of intrauterine growth restriction (IUGR).
  • Aurélie Bourdon
  • Jacob Hannigsberg
  • Emilie Misbert
  • Thang Nhat Tran
  • Valérie Amarger
  • Véronique Ferchaud-Roucher
  • Norbert Winer
  • Dominique Darmaun
  • Clin Nutr.2020 Apr;S0261-5614(20)30154-0. doi: 10.1016/j.clnu.2020.03.036.Epub 2020-04-10.

フレイル高齢者における高血圧の管理-29 カ国の開業医によるガイドライン使用の役割

Managing hypertension in frail oldest-old-The role of guideline use by general practitioners from 29 countries.
  • Céline Roulet
  • Zsofia Rozsnyai
  • Katharina Tabea Jungo
  • Milly A van der Ploeg
  • Carmen Floriani
  • Donata Kurpas
  • Shlomo Vinker
  • Sanda Kreitmayer Pestic
  • Ferdinando Petrazzuoli
  • Kathryn Hoffmann
  • Rita P A Viegas
  • Christian Mallen
  • Athina Tatsioni
  • Hubert Maisonneuve
  • Claire Collins
  • Heidrun Lingner
  • Rosy Tsopra
  • Yolanda Mueller
  • Rosalinde K E Poortvliet
  • Jacobijn Gussekloo
  • Sven Streit
  • PLoS ONE.2020;15(7):e0236064. PONE-D-20-09925. doi: 10.1371/journal.pone.0236064.Epub 2020-07-10.

イングランド北西部の非粘膜性上皮性卵巣癌における生殖細胞型BRCA1/2検査の主流化

Mainstreaming germline BRCA1/2 testing in non-mucinous epithelial ovarian cancer in the North West of England.
  • Nicola Flaum
  • Robert D Morgan
  • George J Burghel
  • Michael Bulman
  • Andrew R Clamp
  • Jurjees Hasan
  • Claire L Mitchell
  • Doina Badea
  • Sarah Moon
  • Martin Hogg
  • Dennis Hadjiyiannakis
  • Tara Clancy
  • Helene Schlecht
  • Emma R Woodward
  • Emma J Crosbie
  • Richard J Edmondson
  • Andrew J Wallace
  • Gordon C Jayson
  • Fiona I Lalloo
  • Elaine F Harkness
  • D Gareth R Evans
  • Eur. J. Hum. Genet..2020 Jul;10.1038/s41431-020-0692-y. doi: 10.1038/s41431-020-0692-y.Epub 2020-07-10.

ホスホジエステラーゼ5A1とアバナフィルの複合体の構造から、イソフォーム選択性の分子基盤とハロゲン結合によるα-ヘリックス骨格酸素の標的化の指針を明らかにした

Structure of Human Phosphodiesterase 5A1 Complexed with Avanafil Reveals Molecular Basis of Isoform Selectivity and Guide-lines for Targeting α-Helix Backbone Oxygen by Halogen Bonding.
  • Chao-Ming Hsieh
  • Chun-Yi Chen
  • Ji-Wang Chern
  • Nei-Li Chan
  • J. Med. Chem..2020 Jul;doi: 10.1021/acs.jmedchem.0c00853.Epub 2020-07-14.

高脂肪食誘発性肥満とD-ガラクトース誘発性老化の動物モデルにおける海馬における脂肪量と肥満関連タンパク質発現の変化

Changes of fat-mass and obesity-associated protein expression in the hippocampus in animal models of high-fat diet-induced obesity and D-galactose-induced aging.
  • Min Soo Kang
  • Woosuk Kim
  • Tae Hyeong Kim
  • Hyo Young Jung
  • Hyun Jung Kwon
  • Dae Won Kim
  • In Koo Hwang
  • Jung Hoon Choi
  • Lab Anim Res.2020;36:20. 46. doi: 10.1186/s42826-020-00046-0.Epub 2020-07-06.

心臓埋め込み型電子機器を装着した患者に対する放射線治療

Radiotherapy in Patients With a Cardiac Implantable Electronic Device.
  • Ardalan Sharifzadehgan
  • Marc Laurans
  • Marine Thuillot
  • Andres Huertas
  • Pierre Baudinaud
  • Kumar Narayanan
  • Mariana Mirabel
  • Jean-Emmanuel Bibault
  • Pierre Frey
  • Victor Waldmann
  • Emilie Varlet
  • Denis Amet
  • Christophe Juin
  • Thomas Lavergne
  • Xavier Jouven
  • Philippe Giraud
  • Catherine Durdux
  • Eloi Marijon
  • Am. J. Cardiol..2020 Aug;128:196-201. S0002-9149(20)30467-7. doi: 10.1016/j.amjcard.2020.04.045.Epub 2020-05-15.

フェロモンオドラントレセプターの反応から、ヨーロッパのトウモロコシボローバー、Ostrinia nubilalisにおける秘密の冗長性フェロモン成分の存在が明らかになった

Pheromone Odorant Receptor Responses Reveal the Presence of a Cryptic, Redundant Sex Pheromone Component in the European Corn Borer, Ostrinia nubilalis.
  • Kevin W Wanner
  • Kevin Moore
  • Jianrong Wei
  • Brent C Herdlicka
  • Charles E Linn
  • Thomas C Baker
  • J. Chem. Ecol..2020 Jul;10.1007/s10886-020-01196-0. doi: 10.1007/s10886-020-01196-0.Epub 2020-07-17.

コートジボワールにおけるHIVに周産期感染した思春期の女性におけるヒト乳頭腫ウイルス感染症

Human papilloma viruses infection among adolescent females perinatally infected with HIV in Côte d'Ivoire.
  • Boris Tchounga
  • Apollinaire Horo
  • Simon Boni
  • Aristophane Tanon
  • Madeleine Amorissani Folquet
  • Isabelle Garrigue
  • Valeriane Leroy
  • François Dabis
  • Didier Ekouevi
  • Antoine Jaquet
  • Sex Transm Infect.2020 Jul;sextrans-2019-054420. doi: 10.1136/sextrans-2019-054420.Epub 2020-07-13.

フロリダ州の消防署における汚染防止対策の実施状況と消防組織レベルの特徴との関連。消防士がんイニシアチブからの証拠

Fire Service Organizational-level Characteristics are Associated with Adherence to Contamination Control Practices in Florida Fire Departments: Evidence from the Firefighter Cancer Initiative.
  • Paola Louzado-Feliciano
  • Kevin A Griffin
  • Katerina M Santiago
  • Natasha Schaefer Solle
  • Tulay Koru-Sengul
  • Casey Grant
  • Neal Niemczyk
  • David J Lee
  • Erin N Kobetz
  • Alberto J Caban-Martinez
  • J. Occup. Environ. Med..2020 Jul;doi: 10.1097/JOM.0000000000001953.Epub 2020-07-07.

α-トコフェロールベースのPEG化リポソームを用いたmicroRNA-134(miR-134)の外因性送達による皮膚扁平上皮癌の効果的な治療法

Exogenous delivery of microRNA-134 (miR-134) using α-tocopherol-based PEGylated liposome for effective treatment in skin squamous cell carcinoma.
  • Chen Jing
  • Li Yan
  • Zhang Wei
  • Zhang Shoumin
  • Yin Guangwen
  • Zhang Jiangan
  • Jia Xuesong
  • Chen Hongxiang
  • Duan Ziyu
  • Li Jianguo
  • Drug Deliv Transl Res.2020 Jun;10.1007/s13346-020-00811-7. doi: 10.1007/s13346-020-00811-7.Epub 2020-06-22.

LncRNAであるFTXは、Kupffer細胞のM1/M2分極を制御することで、非アルコール性脂肪肝疾患から肝細胞癌への進行を抑制することが明らかになった

LncRNA FTX represses the progression of non-alcoholic fatty liver disease to hepatocellular carcinoma via regulating the M1/M2 polarization of Kupffer cells.
  • Huajun Wu
  • Zhiwei Zhong
  • Anji Wang
  • Chunhui Yuan
  • Ke Ning
  • Huanhuan Hu
  • Chao Wang
  • Xiangbao Yin
  • Cancer Cell Int..2020;20:266. 1354. doi: 10.1186/s12935-020-01354-0.Epub 2020-06-24.

プレオトロピンは血管内皮増殖因子受容体2に選択的に結合し、αβインテグリンの発現に依存して細胞移動を阻害または刺激する

Pleiotrophin selectively binds to vascular endothelial growth factor receptor 2 and inhibits or stimulates cell migration depending on αβ integrin expression.
  • Margarita Lamprou
  • Pinelopi Kastana
  • Fani Kofina
  • Ηaralampos Tzoupis
  • Spyridoula Barmpoutsi
  • Md Sanaullah Sajib
  • Marina Koutsioumpa
  • Evangelia Poimenidi
  • Aikaterini A Zompra
  • Dimitrios Tassopoulos
  • Effrosyni Choleva
  • Theodore Tselios
  • Constantinos M Mikelis
  • Evangelia Papadimitriou
  • Angiogenesis.2020 Jul;10.1007/s10456-020-09733-x. doi: 10.1007/s10456-020-09733-x.Epub 2020-07-17.

アヤワスカがナイーブユーザーのメンタルヘルスと生活の質に与える影響。縦断的研究と横断的研究の組み合わせ

Effects of ayahuasca on mental health and quality of life in naïve users: A longitudinal and cross-sectional study combination.
  • Daniel F Jiménez-Garrido
  • María Gómez-Sousa
  • Genís Ona
  • Rafael G Dos Santos
  • Jaime E C Hallak
  • Miguel Ángel Alcázar-Córcoles
  • José Carlos Bouso
  • Sci Rep.2020 Mar;10(1):4075. 10.1038/s41598-020-61169-x. doi: 10.1038/s41598-020-61169-x.Epub 2020-03-05.

酵母細胞壁由来のマンノプロテインの活性画分は、成犬および高齢犬の自然免疫および獲得免疫を刺激する

Active fractions of mannoproteins derived from yeast cell wall stimulate innate and acquired immunity of adult and elderly dogs.
  • F S A Kroll
  • T C Putarov
  • L Zaine
  • K S Venturini
  • C G Aoki
  • J P F Santos
  • V Pedrinelli
  • T H A Vendramini
  • M A Brunetto
  • A C Carciofi
  • Anim. Feed Sci. Technol..2020 Mar;261:114392. S0377-8401(18)31570-0. doi: 10.1016/j.anifeedsci.2020.114392.Epub 2020-01-10.

海洋南極のエコロジー氷河における氷晶石穴生態系のビオトープとバイオセノシス

Biotope and biocenosis of cryoconite hole ecosystems on Ecology Glacier in the maritime Antarctic.
  • Jakub Buda
  • Edyta Łokas
  • Mirosława Pietryka
  • Dorota Richter
  • Wojciech Magowski
  • Nataliia S Iakovenko
  • Dorota L Porazinska
  • Tomasz Budzik
  • Mariusz Grabiec
  • Jakub Grzesiak
  • Piotr Klimaszyk
  • Paweł Gaca
  • Krzysztof Zawierucha
  • Sci. Total Environ..2020 Jul;724:138112. S0048-9697(20)31625-9. doi: 10.1016/j.scitotenv.2020.138112.Epub 2020-03-24.

スプライシングとマイクロプロセッサー複合体の拮抗は、細胞周期再突入のためのLnc-MIRHGの血清誘発処理を決定する

Antagonism between Splicing and Microprocessor complex Dictates the Serum-induced Processing of Lnc-MIRHG for Efficient Cell Cycle Re-entry.
  • Qinyu Sun
  • Qinyu Hao
  • Yo-Chuen Lin
  • You Jin Song
  • Sushant Bangru
  • Waqar Arif
  • Vidisha Tripathi
  • Yang Zhang
  • Jung-Hyun Cho
  • Susan M Freier
  • Lisa Jenkins
  • Jian Ma
  • Je-Hyun Yoon
  • Auinash Kalsotra
  • Ashish Lal
  • Supriya G Prasanth
  • Kannanganattu V Prasanth
  • RNA.2020 Jul;rna.075309.120. doi: 10.1261/rna.075309.120.Epub 2020-07-16.

カーボベルデにおける2015-2016年のジカウイルスアウトブレイクのゲノム疫学

Genomic Epidemiology of 2015-2016 Zika Virus Outbreak in Cape Verde.
  • Oumar Faye
  • Maria de Lourdes Monteiro
  • Bram Vrancken
  • Matthieu Prot
  • Sebastian Lequime
  • Maryam Diarra
  • Oumar Ndiaye
  • Tomas Valdez
  • Sandra Tavarez
  • Jessica Ramos
  • Silvânia da Veiga Leal
  • Cecilio Pires
  • Antonio Moreira
  • Maria Filomena Tavares
  • Linete Fernandes
  • Jorge Noel Barreto
  • Maria do Céu Teixeira
  • Maria da Luz de Lima Mendonça
  • Carolina Cardoso da Silva Leite Gomes
  • Mariano Salazar Castellon
  • Laurence Ma
  • Frédéric Lemoine
  • Fabiana Gámbaro-Roglia
  • Déborah Delaune
  • Gamou Fall
  • Ibrahima Socé Fall
  • Mamadou Diop
  • Anavaj Sakuntabhai
  • Cheikh Loucoubar
  • Philippe Lemey
  • Edward C Holmes
  • Ousmane Faye
  • Amadou Alpha Sall
  • Etienne Simon-Loriere
  • Emerging Infect. Dis..2020 Jun;26(6):1084-1090. doi: 10.3201/eid2606.190928.

エクスパンシン遺伝子ファミリーのゲノムワイドな同定により、エクスパンシン遺伝子が綿花の繊維細胞の成長に関与していることが明らかになった

Genome-wide identification of the expansin gene family reveals that expansin genes are involved in fibre cell growth in cotton.
  • Li-Min Lv
  • Dong-Yun Zuo
  • Xing-Fen Wang
  • Hai-Liang Cheng
  • You-Ping Zhang
  • Qiao-Lian Wang
  • Guo-Li Song
  • Zhi-Ying Ma
  • BMC Plant Biol..2020 May;20(1):223. 10.1186/s12870-020-02362-y. doi: 10.1186/s12870-020-02362-y.Epub 2020-05-19.

微粒子状物質曝露と乳房腫瘍および隣接正常乳房組織における遺伝子発現経路との関与

Involvement of fine particulate matter exposure with gene expression pathways in breast tumor and adjacent-normal breast tissue.
  • Natalie C DuPré
  • Yujing J Heng
  • Benjamin A Raby
  • Kimberly Glass
  • Jaime E Hart
  • Jen-Hwa Chu
  • Catherine Askew
  • A Heather Eliassen
  • Susan E Hankinson
  • Peter Kraft
  • Francine Laden
  • Rulla M Tamimi
  • Environ. Res..2020 Jul;186:109535. S0013-9351(20)30428-X. doi: 10.1016/j.envres.2020.109535.Epub 2020-04-15.

ショウジョウバエメラノガスターの性ペプチドの構造:水酸化イソロイシンの同定とアミノ酸の水酸化パターンの系統変化

The structure of the Drosophila melanogaster sex peptide: Identification of hydroxylated isoleucine and a strain variation in the pattern of amino acid hydroxylation.
  • Sebastian Sturm
  • Adam Dowle
  • Neil Audsley
  • R Elwyn Isaac
  • Insect Biochem. Mol. Biol..2020 Jun;124:103414. S0965-1748(20)30103-X. doi: 10.1016/j.ibmb.2020.103414.Epub 2020-06-24.

危機的に絶滅の危機に瀕している単一島嶼の固有種の鳥では、高いMHC遺伝子コピー数がホモ接合にもかかわらず多様性を維持しているが、MHCに基づく仲間選択の証拠はない

High MHC gene copy number maintains diversity despite homozygosity in a Critically Endangered single-island endemic bird, but no evidence of MHC-based mate choice.
  • Martin Stervander
  • Elisa G Dierickx
  • Jack Thorley
  • M de L Brooke
  • Helena Westerdahl
  • Mol. Ecol..2020 May;doi: 10.1111/mec.15471.Epub 2020-05-16.

肺サルコイドーシスにおける高用量ブデゾニド吸入開始後の臨床経過と血清KL-6レベルの顕著な改善

Remarkable Improvement in Clinical Course and Serum KL-6 Levels after Initiation of High-Dose Inhaled Budesonide in Pulmonary Sarcoidosis.
  • Yoshitaka Morimatsu
  • Masaki Okamoto
  • Tomotaka Kawayama
  • Yusuke Mizoguchi
  • Haruki Imaoka
  • Hideo Ogino
  • Taketoshi Kawazu
  • Tatsuya Ishitake
  • Tomoaki Hoshino
  • Kurume Med J.2020 Jul;66(1):71-75. doi: 10.2739/kurumemedj.MS661003.Epub 2020-05-01.

糖尿病性肩関節炎患者における肩の痛み、機能、可動域の改善における橈骨体外衝撃波治療と超音波ガイド下低用量関節内ステロイド注射の有効性

Effectiveness of radial extracorporeal shock-wave therapy versus ultrasound-guided low-dose intra-articular steroid injection in improving shoulder pain, function, and range of motion in diabetic patients with shoulder adhesive capsulitis.
  • Tasneem El Desouky Mohammed El Naggar
  • Ahmed Ibrahim Elsayed Maaty
  • Aly Elsayed Mohamed
  • J Shoulder Elbow Surg.2020 Jul;29(7):1300-1309. S1058-2746(20)30265-2. doi: 10.1016/j.jse.2020.03.005.