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日本語AIでPubMedを検索

日本語AIでPubMedを検索

PubMedの提供する医学論文データベースを日本語で検索できます。AI(Deep Learning)を活用した機械翻訳エンジンにより、精度高く日本語へ翻訳された論文をご参照いただけます。

みんなが読んでいる論文

インドのプライマリケアにおける重度のうつ病に対するカウンセラーによる短時間の心理的治療であるヘルシーアクティビティプログラム(HAP):無作為化比較試験

The Healthy Activity Program (HAP), a lay counsellor-delivered brief psychological treatment for severe depression, in primary care in India: a randomised controlled trial.
  • Vikram Patel
  • Benedict Weobong
  • Helen A Weiss
  • Arpita Anand
  • Bhargav Bhat
  • Basavraj Katti
  • Sona Dimidjian
  • Ricardo Araya
  • Steve D Hollon
  • Michael King
  • Lakshmi Vijayakumar
  • A-La Park
  • David McDaid
  • Terry Wilson
  • Richard Velleman
  • Betty R Kirkwood
  • Christopher G Fairburn
  • Lancet.2017 01;389(10065):176-185. S0140-6736(16)31589-6. doi: 10.1016/S0140-6736(16)31589-6.Epub 2016-12-15.

YBX1はp110βを標的とすることでオートファジーを仲介し、NSCLCにおけるシスプラチン感受性を低下させています

YBX1 mediates autophagy by targeting p110β and decreasing the sensitivity to cisplatin in NSCLC.
  • Yanwei Cui
  • Fengzhou Li
  • Qiang Xie
  • Shilei Zhao
  • Tao Guo
  • Ping Guo
  • Sheng Hu
  • Jiaojiao Hao
  • Chunfang Tian
  • Wendan Yu
  • Zhuoshi Li
  • Lei Fang
  • Lei Zhao
  • Manyu Chen
  • Taihua Wu
  • Chundong Gu
  • Cell Death Dis.2020 Jun;11(6):476. 10.1038/s41419-020-2555-4. doi: 10.1038/s41419-020-2555-4.Epub 2020-06-19.

リン酸化プロテオーム解析により、CLK1 が胃癌の新規治療標的であることが明らかになった

Phosphoproteomic analysis identifies CLK1 as a novel therapeutic target in gastric cancer.
  • Niraj Babu
  • Sneha M Pinto
  • Manjusha Biswas
  • Tejaswini Subbannayya
  • Manoj Rajappa
  • Sonali V Mohan
  • Jayshree Advani
  • Pavithra Rajagopalan
  • Gajanan Sathe
  • Nazia Syed
  • Vinod D Radhakrishna
  • Oliyarasi Muthusamy
  • Sanjay Navani
  • Rekha V Kumar
  • Gopal Gopisetty
  • Thangarajan Rajkumar
  • Padhma Radhakrishnan
  • Saravanan Thiyagarajan
  • Akhilesh Pandey
  • Harsha Gowda
  • Pradip Majumder
  • Aditi Chatterjee
  • Gastric Cancer.2020 Apr;10.1007/s10120-020-01062-8. doi: 10.1007/s10120-020-01062-8.Epub 2020-04-24.

気管支肺胞液中の単純ヘルペスウイルス 1 型患者の機械換気患者の転帰に及ぼす抗ウイルス療法の効果:レトロスペクティブコホート研究

Effect of antiviral therapy on the outcome of mechanically ventilated patients with herpes simplex virus type 1 in bronchoalveolar lavage fluid: a retrospective cohort study.
  • Elisabeth Heimes
  • Michael Baier
  • Christina Forstner
  • Sebastian Weis
  • Michael Bauer
  • Michael Fritzenwanger
  • André Scherag
  • Mathias W Pletz
  • Miriam Kesselmeier
  • Stefan Hagel
  • Chest.2020 Jul;S0012-3692(20)31854-7. doi: 10.1016/j.chest.2020.06.056.Epub 2020-07-03.

チモロールマレイン酸塩を担持した第四級キトサン系感熱性ハイドロゲルの合成と特性:緑内障治療のための透明な外用眼球送達システム

Synthesis and characterization of timolol maleate-loaded quaternized chitosan-based thermosensitive hydrogel: A transparent topical ocular delivery system for the treatment of glaucoma.
  • Yousef Pakzad
  • Marziyeh Fathi
  • Yadollah Omidi
  • Masoud Mozafari
  • Ali Zamanian
  • Int. J. Biol. Macromol..2020 May;159:117-128. S0141-8130(20)33145-7. doi: 10.1016/j.ijbiomac.2020.04.274.Epub 2020-05-05.

DUODENAL-JEJUNAL BYPASSが視床下部肥満ラットの褐色付着部における脂質蓄積を減少させることを明らかにした

DUODENAL-JEJUNAL BYPASS REDUCES LIPID ACCUMULATION IN THE BROWN ADIPOSE TISSUE OF HYPOTHALAMIC OBESE RATS.
  • Vanessa Marieli Ceglarek
  • Zoé Maria Guareschi
  • Gabriela Moreira-Soares
  • Rafaela Cristiane Ecker-Passarello
  • Sandra Lucinei Balbo
  • Maria Lúcia Bonfleur
  • Sabrina Grassiolli
  • Arq Bras Cir Dig.2020 Jul;33(1):e1497. S0102-67202020000100307. doi: 10.1590/0102-672020190001e1497.

α-シヌクレイン神経毒性のリピドミクス解析によりステアロイルCoAデサチュラーゼをパーキンソン治療の標的として同定

Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment.
  • Saranna Fanning
  • Aftabul Haque
  • Thibaut Imberdis
  • Valeriya Baru
  • M Inmaculada Barrasa
  • Silke Nuber
  • Daniel Termine
  • Nagendran Ramalingam
  • Gary P H Ho
  • Tallie Noble
  • Jackson Sandoe
  • Yali Lou
  • Dirk Landgraf
  • Yelena Freyzon
  • Gregory Newby
  • Frank Soldner
  • Elizabeth Terry-Kantor
  • Tae-Eun Kim
  • Harald F Hofbauer
  • Michel Becuwe
  • Rudolf Jaenisch
  • David Pincus
  • Clary B Clish
  • Tobias C Walther
  • Robert V Farese
  • Supriya Srinivasan
  • Michael A Welte
  • Sepp D Kohlwein
  • Ulf Dettmer
  • Susan Lindquist
  • Dennis Selkoe
  • Mol. Cell.2019 03;73(5):1001-1014.e8. S1097-2765(18)30998-5. doi: 10.1016/j.molcel.2018.11.028.Epub 2018-12-04.

完全磁気浮上式の小型遠心式左室補助装置の脈動運転下での血行動態性能。脈動運転下での完全磁気浮上式小型遠心式左室補助装置の血行動態性能:in vitro試験

Hemodynamic performance of a compact centrifugal left ventricular assist device with fully magnetic levitation under pulsatile operation: An in vitro study.
  • Tingting Wu
  • Hao Lin
  • Yuxin Zhu
  • Penghui Huang
  • Frank Lin
  • Chen Chen
  • Po-Lin Hsu
  • Proc Inst Mech Eng H.2020 Jul;:954411920937919. doi: 10.1177/0954411920937919.Epub 2020-07-10.

均一な粒子径とユニークな輸送タンパク質関連タンパク質コロナを持つFe/Mg修飾炭酸アパタイトは、乳がん細胞にドキソルビシンを効率的に送達する

Fe/Mg-Modified Carbonate Apatite with Uniform Particle Size and Unique Transport Protein-Related Protein Corona Efficiently Delivers Doxorubicin into Breast Cancer Cells.
  • Sheikh Tanzina Haque
  • Md Emranul Karim
  • Syafiq Asnawi Zainal Abidin
  • Iekhsan Othman
  • Mark M Banaszak Holl
  • Ezharul Hoque Chowdhury
  • Nanomaterials (Basel).2020 Apr;10(5). E834. doi: 10.3390/nano10050834.Epub 2020-04-27.

間葉系幹細胞由来の生体適合性膜ベシクルは、ヒト単核球の活性化と増殖を抑制する免疫調節活性を示す

Mesenchymal Stem Cell Derived Biocompatible Membrane Vesicles Demonstrate Immunomodulatory Activity Inhibiting Activation and proliferation of Human Mononuclear Cells.
  • Marina O Gomzikova
  • Sevindzh K Kletukhina
  • Sirina V Kurbangaleeva
  • Olga A Neustroeva
  • Olga S Vasileva
  • Ekaterina E Garanina
  • Svetlana F Khaiboullina
  • Albert A Rizvanov
  • Pharmaceutics.2020 Jun;12(6). E577. doi: 10.3390/pharmaceutics12060577.Epub 2020-06-23.

COVID-19患者に対する回復期血漿または高免疫性免疫グロブリン:生きたシステマティックレビュー

Convalescent plasma or hyperimmune immunoglobulin for people with COVID-19: a living systematic review.
  • Vanessa Piechotta
  • Khai Li Chai
  • Sarah J Valk
  • Carolyn Doree
  • Ina Monsef
  • Erica M Wood
  • Abigail Lamikanra
  • Catherine Kimber
  • Zoe McQuilten
  • Cynthia So-Osman
  • Lise J Estcourt
  • Nicole Skoetz
  • Cochrane Database Syst Rev.2020 07;7:CD013600. doi: 10.1002/14651858.CD013600.pub2.Epub 2020-07-10.

クルクミンによるGSK-3β阻害は、ヒト神経芽腫細胞において、TFEBの活性化と抗酸化活性を介してアミロイド生成を抑制します

GSK-3β inhibition by curcumin mitigates amyloidogenesis via TFEB activation and anti-oxidative Activity in human neuroblastoma cells.
  • Hyun-Chul Song
  • Yubing Chen
  • Yingqing Chen
  • Jeongmin Park
  • Min Zheng
  • Young-Joon Surh
  • Uh-Hyun Kim
  • Jeong Woo Park
  • Rina Yu
  • Hun Taeg Chung
  • Yeonsoo Joe
  • Free Radic. Res..2020 Jul;:1-39. doi: 10.1080/10715762.2020.1791843.Epub 2020-07-06.

慢性HBV感染症患者におけるB型肝炎表面抗原のウイルス特異的およびグローバルT細胞に対する効果

Effects of Hepatitis B Surface Antigen on Virus-specific and Global T Cells in Patients With Chronic HBV infection.
  • Nina Le Bert
  • Upkar S Gill
  • Michelle Hong
  • Kamini Kunasegaran
  • Damien Z M Tan
  • Raidah Ahmad
  • Yang Cheng
  • Charles-A Dutertre
  • Andreas Heinecke
  • Laura Rivino
  • Anthony Tan
  • Navjyot K Hansi
  • Min Zhang
  • Sujuan Xi
  • Yutian Chong
  • Stefan Pflanz
  • Evan W Newell
  • Patrick T F Kennedy
  • Antonio Bertoletti
  • Gastroenterology.2020 Apr;S0016-5085(20)30492-3. doi: 10.1053/j.gastro.2020.04.019.Epub 2020-04-14.

非骨髄芽腫性β-サラサラ血症マウスにおけるβ-サラサラ血症患者由来の遺伝的に補正されたiPSCの安全性と有効性

The safety and effectiveness of genetically corrected iPSCs derived from β-thalassaemia patients in nonmyeloablative β-thalassaemic mice.
  • Yexing Xian
  • Yingjun Xie
  • Bing Song
  • Zhanhui Ou
  • Shuming Ouyang
  • Yuhuan Xie
  • Yi Yang
  • Zeyu Xiong
  • Haoxian Li
  • Xiaofang Sun
  • Stem Cell Res Ther.2020 Jul;11(1):288. 10.1186/s13287-020-01765-w. doi: 10.1186/s13287-020-01765-w.Epub 2020-07-16.

脳微小透析研究のためのバイオマトリックス中の物理化学的特性と未結合画分に基づく中枢神経系薬剤候補の除外

Exclusion of unsuitable CNS drug candidates based on their physicochemical properties and unbound fractions in biomatrices for brain microdialysis investigations.
  • Qianwen Wang
  • Tianjing Ren
  • Jiajia Zhao
  • Chun-Ho Wong
  • H Y Edwin Chan
  • Zhong Zuo
  • J Pharm Biomed Anal.2020 Jan;178:112946. S0731-7085(19)30281-X. doi: 10.1016/j.jpba.2019.112946.Epub 2019-10-25.

Brachiaria brizanthaへのEnterolobium cyclocarpumポッドおよびGliricidia sepium飼料の添加が乾物分解、揮発性脂肪酸濃度、およびin vitroメタン生産に及ぼす影響

Effect of the addition of Enterolobium cyclocarpum pods and Gliricidia sepium forage to Brachiaria brizantha on dry matter degradation, volatile fatty acid concentration, and in vitro methane production.
  • Isabel Cristina Molina-Botero
  • Johanna Mazabel
  • Jeyder Arceo-Castillo
  • José Luis Urrea-Benítez
  • Leticia Olivera-Castillo
  • Rolando Barahona-Rosales
  • Ngonidzashe Chirinda
  • Juan Ku-Vera
  • Jacobo Arango
  • Trop Anim Health Prod.2020 Jul;10.1007/s11250-020-02324-4. doi: 10.1007/s11250-020-02324-4.Epub 2020-07-09.

TOR1AIP1-associated nuclear envelopathiesの表現型をさらに拡大した2つの新規症例

Two novel cases further expand the phenotype of TOR1AIP1-associated nuclear envelopathies.
  • Ivana Lessel
  • Mei-Jan Chen
  • Sabine Lüttgen
  • Florian Arndt
  • Sigrid Fuchs
  • Stefanie Meien
  • Holger Thiele
  • Julie R Jones
  • Brandon R Shaw
  • David K Crossman
  • Peter Nürnberg
  • Bruce R Korf
  • Christian Kubisch
  • Davor Lessel
  • Hum. Genet..2020 Apr;139(4):483-498. 10.1007/s00439-019-02105-6. doi: 10.1007/s00439-019-02105-6.Epub 2020-02-13.

リトアニアの IPV ワクチン接種児を対象とした 1 価経口 2 型サビンポリオワクチン接種後の免疫原性と安全性に関する無作為化第 4 相試験

A randomized phase 4 study of immunogenicity and safety following monovalent oral type 2 Sabin polio vaccine challenge in IPV-vaccinated children in Lithuania.
  • Ananda S Bandyopadhyay
  • Chris Gast
  • Elizabeth B Brickley
  • Ricardo Rüttimann
  • Ralf Clemens
  • M Steven Oberste
  • William C Weldon
  • Margaret E Ackerman
  • Ruth I Connor
  • Wendy F Wieland-Alter
  • Peter Wright
  • Vytautas Usonis
  • J. Infect. Dis..2020 Jul;jiaa390. doi: 10.1093/infdis/jiaa390.Epub 2020-07-04.

根管形成における交渉、グライドパス、プレフレアの手順が根管形成に与える影響-用語、基本概念、および系統的なレビュー

Influence of Negotiation, Glide Path, and Preflaring Procedures on Root Canal Shaping-Terminology, Basic Concepts, and a Systematic Review.
  • Gianluca Plotino
  • Venkateshbabu Nagendrababu
  • Frederic Bukiet
  • Nicola M Grande
  • Sajesh K Veettil
  • Gustavo De-Deus
  • Hany Mohamed Aly Ahmed
  • J Endod.2020 Jun;46(6):707-729. S0099-2399(20)30076-5. doi: 10.1016/j.joen.2020.01.023.Epub 2020-04-22.

骨粗鬆症性椎体圧迫骨折(OVCF)患者の治療における片側と両側の経皮的弯曲術の比較:システマティックレビューとメタアナリシス

Comparison of unilateral versus bilateral percutaneous kyphoplasty for the treatment of patients with osteoporosis vertebral compression fracture (OVCF): a systematic review and meta-analysis.
  • Xing Cheng
  • Hou-Qing Long
  • Jing-Hui Xu
  • Yang-Liang Huang
  • Fo-Bao Li
  • Eur Spine J.2016 11;25(11):3439-3449. 10.1007/s00586-016-4395-6. doi: 10.1007/s00586-016-4395-6.Epub 2016-01-27.

5αリダクターゼ阻害剤の共投与は、処方されたグルココルチコイドの有害な代謝作用を悪化させる

Co-administration of 5α-reductase inhibitors worsens the adverse metabolic effects of prescribed glucocorticoids.
  • Nantia Othonos
  • Thomas Marjot
  • Conor Woods
  • Jonathan M Hazlehurst
  • Nikolaos Nikolaou
  • Riccardo Pofi
  • Sarah White
  • Ilaria Bonaventura
  • Craig Webster
  • Joanne Duffy
  • Thomas Cornfield
  • Ahmad Moolla
  • Andrea M Isidori
  • Leanne Hodson
  • Jeremy W Tomlinson
  • J. Clin. Endocrinol. Metab..2020 Jun;dgaa408. doi: 10.1210/clinem/dgaa408.Epub 2020-06-27.

ルネッサンスへの準備:COVID-19パンデミック時の乳がんの治療と、ユニバーサル・ヘルスケア・システム内での日常的な外科的ケアへの安全な再浮上のための計画

Preparing for the renaissance: treating breast cancer during the COVID-19 pandemic and planning for a safe re-emergence to routine surgical care within a universal health care system.
  • D Berger-Richardson
  • G Ko
  • N J Look Hong
  • Curr Oncol.2020 06;27(3):163-168. conc-27-163. doi: 10.3747/co.27.6699.Epub 2020-06-01.